WorldCat Identities

IMPERIAL COLL OF SCIENCE TECHNOLOGY AND MEDICINE LONDON (Great Britain)

Overview
Works: 5 works in 6 publications in 1 language and 6 library holdings
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Most widely held works by IMPERIAL COLL OF SCIENCE TECHNOLOGY AND MEDICINE LONDON (Great Britain)
Effects of Three-Dimensional Imposed Disturbance on Bluff-Body Near Wake Flows( )

2 editions published between 1993 and 1994 in English and held by 2 WorldCat member libraries worldwide

Research Goals: To achieve a better understanding of the underlying three-dimensional flow structure in the near wake of a nominally two- dimensional bluff body. To understand the effects of three-dimensional features that are characterised by vortex splitting and looping on wake parameters such as base pressure, vortex shedding frequency, wake width and vortex formation length. An underlying aim is to investigate why, for Reynolds numbers greater than a few hundred, some flow quantities predicted by two-dimensional numerical simulations of bluff body flows are not always in good agreement with experiment. Objectives: (1) To control the occurrence of three-dimensionality in the shed vortices by applying mild three-dimensional geometric disturbances along the span. (2) To study the effects of geometric disturbances on wake parameters such as: Strouhal number, base pressure and vortex formation length. (3) To visualize vortex dislocations and the various modes of shedding. (4) To understand the dynamics of vortex dislocations. (KAR) p. 2
Identification of Molecular Receptors for Therapeutic Targeting in Prostate Cancer( )

1 edition published in 2009 in English and held by 1 WorldCat member library worldwide

Prostate cancer is a difficult disease to treat due to its molecular heterogeneity and diverse clinical outcomes. Current therapies for treating and diagnosing prostate cancer are unsatisfactory, suggesting that new strategies and molecular markers are greatly needed. Tumor cells express specific cell surface receptor complexes for rapid growth and survival. Specific receptor-ligand complexes have profound biological functions such as cell signaling and growth. For example, androgen receptor complex plays a critical role in prostate tumor growth and response to hormone therapy. We propose to identify new receptor-ligand pairs for prostate cancer. We have developed a sophisticated targeting system to probe the tumor vasculature in vivo by phage display technology. We plan to inject phage peptides libraries into prostate tumor-bearing mice to identify specific peptides targeting to the tumor and not to the normal tissues. The tumor-specific peptides will be recovered and analyzed by molecular and biochemical methods. The tumor-specific peptides will be used as a bait to identify and clone the binding receptors by affinity chromatography and biochemical cell fractionation approaches. If we are successful, we will identify new biologically relevant receptor-ligand pairs that may be developed for therapeutic applications for prostate cancer
Proceedings of the International Conference on Narrow Gap Semiconductors 1992 (6th) Held in Southampton, United Kingdom on July 19-23, 1992( Book )

1 edition published in 1992 in English and held by 1 WorldCat member library worldwide

Abstracts of Presentations at Workshop on Unsteady and Two-Phase-Flows, Held in London, England on June 28-29, 1990( Book )

1 edition published in 1990 in English and held by 1 WorldCat member library worldwide

In-Cylinder Projectiles( )

1 edition published in 1990 in English and held by 1 WorldCat member library worldwide

Research achievements include: (1) Evidence of the turbulent nature of the unsteady boundary layer along the barrel of the low-speed simulators and the provision of pressure and velocity data used at the Ernst Mach Inst. in their development of a calculation method; (2) Confirmation of the near- isentropic nature of the gas expansion in the second and third simulators with the largest deviation less than 4% of local measurements; (3) Quantification of the extent to which 40 micron solid particles initially lag and subsequently lead the gas flow in the second simulator and provision of evidence to support clustering of particles with terminal velocity related to the cluster; and (4) Evidence of slight blow-back of gas with consequent increase in wall temperature in front of the projectile; quantification of the rapid temperature increase immediately after the projectile and analysis of results in terms of heat flow and heat-transfer coefficient. (EDC)
 
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