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QUEEN'S UNIV KINGSTON (Ont.)

Overview
Works: 34 works in 50 publications in 1 language and 49 library holdings
Publication Timeline
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Most widely held works by QUEEN'S UNIV KINGSTON (Ont.)
Performance Characteristics of Leaky Coaxial Cables by James Lyle Mason( Book )

1 edition published in 1980 in English and held by 1 WorldCat member library worldwide

This work deals with guided radar and reports on the experiments and analysis that were performed to obtain information on the function of leaky coaxial cables used as radio frequency intrusion sensors. Four subjects were investigated: (1) environmental effects on the leaky coaxial cable and the guided radar system, (2) use of doppler shift caused by an intruder to determine the velocity and direction of the intruder, (3) target identification, classification and signature, and (4) a single leaky coaxial cable intrusion detection system. The most important environmental factor was moisture, either rain or snow. Results have demonstrated that the velocity of a target moving longitudinally between the leaky cable sensors can be measured, based on the doppler shift in the return signal. Rudimentary target classification has been demonstrated based on a defined target signature--the log-magnitude of the Fourier transform of the target vector. A single cable intrusion detection system was investigated which incorporated a modulation technique which allowed the intruder to be located. (Author)
Effects of Human Pregnancy on Responses to Exercise Above and Below the Ventilatory Anaerobic Threshold( Book )

2 editions published in 1997 in English and held by 1 WorldCat member library worldwide

The purpose of this contract is to study the effects of healthy human pregnancy on cardiac autonomic function (Study #1), oxygen uptake kinetics (Study #2), and acid-base regulation (Study #3) at rest and during upright cycling at intensities above and below the ventilatory anaerobic threshold (T(vent)). Study #1 is currently in progress and results to date support our hypotheses that cardiac parasympathetic nervous system activity is blunted in the resting state and that sympathetic activity is reduced during strenuous exercise above T(vent) in late gestation. Technical aspects of the study and the testing protocol have been finalized for Study #2 and data collection will begin in January 1998. Study #3 is essentially complete and supports the concept that arterialized plasma H+ is lower in the pregnant vs. nonpregnant state. However, changes in H+ induced by standardized strenuous exercise are comparable in the pregnant vs. nonpregnant state. Nonpregnant subjects may have greater reductions in the strong ion difference (SID) in response to exercise above (T(vent)), but this is compensated by a greater respiratory response and a reduced arterial plasma carbon dioxide tension. Our results to date support the hypothesis that healthy physically active women can safely adapt to short bouts of strenuous exercise in late gestation
Role of Stat3 and ErbB2 in Breast Cancer( Book )

1 edition published in 2010 in English and held by 1 WorldCat member library worldwide

Stat3 is activated by cytokine receptors as well as receptor and non-receptor tyrosine kinases. Activation of Stat3 has been demonstrated in breast and other cancers, while a constitutively active form of Stat3, Stat3C, is able to transform cultured cells, further pointing to an etiologic role for Stat3 in these tumors. However, the exact mechanism of its activation as well as the role of Stat3 in these tumors, remain to be determined. This study focuses on the identification of the upstream activators of Stat3 in confluent cells as well as the role of Stat3 in this setting. A quantitative RT-PCR array experiment using mouse breast epithelial HC11 cells demonstrated a dramatic increase in the levels of secreted IL6 family cytokines, while knockdown experiments demonstrated that this increase is required for Stat3 activation. We also demonstrated that density causes a dramatic increase in levels and activity of the Rac GTPase, due to inhibition of proteasomal degradation. Furthermore, we demonstrated that expression of mutationally activated Rac(exp V12) leads to Stat3 activation through IL6 secretion, and this is required for cell motility, indicating that the gp130/Stat3 axis represents an essential effector for the regulation of key cellular functions. Examination of the role of Stat3 in confluent cultures showed that Stat3 inhibition leads to a dramatic activation of the p53 anti-oncogene. Interestingly, our results also showed that Stat3 inhibition in normal breast epithelial cells induced the p53 target, p21(exp CIP/WAF) but only at lower densities, consistent with previous results showing that p21(exp CIP/WAF) is associated with p53-mediated growth arrest
Evaluating Teachers. Research and Information Report by J. Dale Burnett( Book )

1 edition published in 1975 in English and held by 1 WorldCat member library worldwide

A list of the current approaches to teacher evaluation should include the following: (1) examination of student gain scores on standardized tests, (2) analysis of typical student improvement, (3) teaching performance testing, (4) teacher skill testing, (5) administrator or peer group observations and ratings, and (6) student observations and ratings. The first three approaches tend to emphasize the product dimension of teaching, whereas the latter three focus more on the process of teaching. Most of the research activities on teacher evaluation have concentrated on the molecular level of teaching--the processes and results that occur within a classroom setting--whereas administrative concerns seem to be more at the molar level--the overall workload and attendant results. One way of performing formative evaluation at the molar level while increasing teacher morale is to incorporate elements of management by objectives. This is what has been done in the Faculty Performance Objective Form designed for the faculty of education at Queen's University. This instrument (included in an appendix) can be used in overall and specific planning; as an additional form of motivation for individual faculty; and as a source of information for promotions, tenure, and firing. (Author/IRT)
Role of Hepatocyte Growth Factor Autocrine Loop in Growth and Metastasis of Breast Cancer( Book )

3 editions published between 1997 and 2000 in English and held by 1 WorldCat member library worldwide

Recent evidence has shown that hepatocyte growth factor (HGF) is upregulated in human breast cancer, and that this high level of expression is a reliable indicator of recurrence and of poor overall survival of breast cancer patients. We have recently demonstrated co-expression of HGF and HGF receptor (Met) mRNA in invasive human breast carcinomas, as well as in regions of benign hyperplasia. In contrast, most nonmalignant epithelia express Met, but not HGF. These observations suggest that aberrant expression of HGF and subsequent establishment of an autocrine HGF loop could lead to abnormal growth, tumorigenesis and metastasis. The objectives of this grant are: (a) to assess expression of HGF and Met in nonmalignant and malignant breast epithelia, (b) to examine the transcriptional and post-transcriptional mechanisms of regulation of HGF mRNA and protein, and (c) to determine if upregulating, or downregulating HGF or Met expression affects the transformed and tumorigenic phenotypes of mammary carcinoma cells in vitro and in vivo
Asymptotic Efficiency of the Maximum Likelihood Estimator of a Parameter for the M/G/1 Queueing System( Book )

1 edition published in 1992 in English and held by 1 WorldCat member library worldwide

This paper discusses asymptotic efficiency of the maximum likelihood estimator of the parameters of the M/G/1 queueing system for full likelihood and reduced likelihood functions. The efficiency of the maximum likelihood estimator of the reduced likelihood function relative to full likelihood function is derived
SOME EFFECTS OF MICROSTRUCTURE ON CHIP FORMATION( Book )

1 edition published in 1962 in English and held by 1 WorldCat member library worldwide

The paper describes some effects of microstructure on chip formation in 0.4 per cent plain carbon steel for three distinctly different microstructures, each having the same bulk hardness. In each case the chips were quite different. Some tentative conclusions concerning the mechanism of chip formation are presented. (Author)
Calibration Issues of Tekscan Systems for Human Pressure Assessment by Evelyn L Morin( Book )

1 edition published in 2001 in English and held by 1 WorldCat member library worldwide

The Tekscan pressure sensor system has been designed for relatively easy measurement of contact pressures between two opposing surfaces. However, several factors are known to affect Tekscan sensor output. This paper reports on two pilot studies which were done to investigate the effects of contact surface compliance and changes in the system hardware on Tekscan sensor output In the first study linear calibration curves were calculated for a single Tekscan sensor array placed on surfaces of varying compliance. The slopes of the curves and variability in both the slopes and intercepts were found to be affected by surface compliance. In the second study, absolute percentage differences in the raw output data bits between a series of Tekscan sensor-cuff combinations were calculated. These differences ranged from 5-32). The results of these studies indicate that careful attention must be paid to system set-up and calibration when using that Tekscan pressure sensor system to measure contact pressures
Training the Absolute Identification of Pitch( Book )

1 edition published in 1969 in English and held by 1 WorldCat member library worldwide

Two methods for training the absolute judgment of pitch, reference training and series training, were studied. Reference training concentrated during training on the identification of three reference tones in a set of nine pure tones, while series training gave equal weight during training to the identification of all nine tones. Results of pre- and posttraining tests, scored for the number of correct judgments, showed that reference training was more effective than series training for listeners with musical experience. In addition, discriminability (d) scaling of pre- and posttest performance indicated that reference training was particularly effective for training listeners with musical experience when the nine tones of a set were grouped into three pitch classes-high, medium, and low pitch. Listeners without musical experience benefited from both training methods, but their overall improvement was less than that for musical listeners. (Author)
Identification of Hepatocyte Growth Factor Autocrine Loops in Breast Carcinomas: Possible Target for Therapeuti Intervention( )

2 editions published between 2000 and 2003 in English and held by 0 WorldCat member libraries worldwide

We previously demonstrated elevated HGF and Met expression in regions of invasive human breast carcinomas, suggesting a role of autocrine HGF loops in invasive breast cancer. We have now demonstrated that: (a) elevated HGF and Met expression occurs in some newly-derived breast and non-small cell lung carcinoma cell lines; and (b) three carcinoma cell lines showed autocrine tyrosine-phosphorylation of Met and increased cell survival, consistent with the presence of autocrine HOE loops. These findings suggest that targeting autocrine HOE loops is an important strategy for therapeutic intervention in breast cancer metastasis. Based on 3-D computer modelling of the Met receptor binding site in the K1 kringle domain of HOE, we have initiated a phage display approach to screen 7-lO mer peptide libraries for putative peptide antagonists of HOE that block ligand receptor binding. These putative peptide antagonists will be isolated, and tested for the ability to inhibit tumorigenesis and metastasis of breast carcinoma cells
Identification of Hepatocyte Growth Factor Autocrine Loops in Breast Carcinomas: Possible Target for Therapeutic Intervention( )

2 editions published between 2001 and 2002 in English and held by 0 WorldCat member libraries worldwide

HGF (also known as scatter factor), and its receptor Met, are over-expressed in invasive human breast cancer. In addition, increased HGF expression and sustained activation of Met have been shown to be important steps in the development of metastatic breast cancer. Therefore, HGF-Met binding is a potential target for anti-cancer antagonists in the treatment of breast cancer metastasis. We have developed an HGF-Met binding assay where Met is immobilized on a plastic plate, followed by the addition of HGF and subsequent detection of HGF binding. Addition of varying compounds/peptides can be monitored for induction of increased or decreased HGF-Met binding. We are using a new technology, known as 'phage display', to isolate short peptides which bind specifically to HGF or Met and block growth factor function. Additionally, we have shown that certain divalent cations (e.g., Cu(2+)) can inhibit HGF-Met binding. Once antagonistic peptides/compounds have been identified, their putative effect on cell functions such as Met activation, cell motility and invasion will be assessed. This approach could lead to the development of novel inhibitors of HGF function in carcinoma cells, and new strategies for improved treatment of breast cancer, perhaps in combination with other anti-cancer agents
Assessment of Design Modifications to Final Clothe the Soldier Rucksack( )

1 edition published in 2006 in English and held by 0 WorldCat member libraries worldwide

A modification from Velco and strapping to a sewn attachment method for the shoulder straps of the Clothe the Soldier (CTS) Rucksack was evaluated for: load control, dynamic peak loading and pressure distribution to the torso. Quantitative assessment of these functional parameters was undertaken to compare the behaviour of a proposed modification to that of the currently fielded design to ensure no degradation in performance. This modification was proposed to address problems that have arisen with the current shoulder strap attachment when loads carried in the rucksack increased from 25 to approximately 45 kg. The CTS load carriage system includes the Tactical Vest (TV), the Rucksack, and a Small Pack System which have been designed to be compatible. In addition to wearing the TV and one of the packs, soldiers are increasingly attempting to wear the Fragmentation Protection Vest (FPV), with Bullet Resistant Plates (BRP) beneath the TV and Rucksack. The purpose of testing was to quantify any impact of the modified shoulder attachment design on the following parameters: a soldier's load control ability, the pressure distribution under the rucksack, the range of motion of the trunk or the mechanical energy cost of walking. Both CTS designs were tested dynamically on the Load Carriage Simulator and on the Compliance tester
Regulation of Anchorage-Independent Growth in Breast Cancer: Role of Signalling by Extracellular Matrix and Growth Factors( )

3 editions published between 1995 and 1997 in English and held by 0 WorldCat member libraries worldwide

Our main goal is to better understand the mechanisms by which extracellular matrix and growth factors can promote anchorage-independent growth of a murine mammary carcinoma cell line. Our objectives are to investigate: (l) (a) the role of fibronectin and the alpha 5 Beta 1 integrin in SP1 cell survival as well as, (b) the phosphorylation status of FAK under anchorage independent conditions; (2) the role of HGF and TGF-Beta in SP1 mediated cell survival; (3) and the role of PI 3-kinase in SP1 cell survival and anchorage-independent growth
Assessment of the effect of No Stay, Bent Stay or Straight Stay when the Clothe the Soldier Rucksack is Worn with the Fragmentation Vest( )

1 edition published in 2006 in English and held by 0 WorldCat member libraries worldwide

The Clothe the Soldier (CTS) load carriage system includes the Fragmentation Protection Vest (FPV) with Bullet Resistant Plates (BRP), Tactical Vest (TV), the Rucksack, and a Small Pack System which have been designed to be compatible Loads carried in the CTS rucksack often exceed the officially recommended 25 kg and are reported to approach 45 kg. Under these conditions, optimizing load distribution onto the torso becomes even more essential. The purpose of this work was to examine the effects of various stays in the rucksack (straight stays, bent stays, and no stay) on pressure effects and load distribution to the body. Results showed that wearing the FPV and TV under the rucksack will increase the compressive load on the upper body by 50 to 100 percent, depending on the stay configuration compared with wearing just the TV and Rucksack configuration. Stays bent to conform to the body were the most effective configuration while removal of the stays caused the greatest increase in compressive loads. Edges of the BRP caused multiple peak pressure points of with values on the mannikin of 60 to 110 kPa. These pressure values are expected to considerably exceed the tissue tolerance of skin and underlying muscle and are expected to result in localized skin damage and bruising
Clothe the Soldier Prototype Modular Load Carriage System Design Assessment using the APLCS Load Carriage Simulator( )

1 edition published in 2006 in English and held by 0 WorldCat member libraries worldwide

The objective of this study was to conduct a standardized assessment of the CTS prototype modular (M1) pack on a computerized Load Carriage (LC) Simulator. Specifically, the LC Simulator measured variables which assess load control and load transfer capability of the M1 pack. These aspects of pack design were comprised of several displacement, force, moment and pressure variables that had been validated on previously tested systems where LC Simulator outputs were compared to assessments by experienced users during human trials
Determining the Function of the Fps/Fes Proto-Oncogene in Breast Development and Malignancy( )

2 editions published between 2004 and 2005 in English and held by 0 WorldCat member libraries worldwide

The fps/fes proto-oncogene encodes a 92 kDa protein tyrosine kinase. To understand the physiological function of Fps we have generated a knockout mouse line that lacks Fps expression. Fps-knockout female mice produce litters that gain weight more slowly than wildtype mice, and develop breast tumors more quickly than wildtype mice. These data suggest that Fps participates in regulating mammary gland development and tumorigenesis. To address these hypotheses we are examining the biological and biochemical function(Fps) of Fps in the mammary gland. To date, we have shown that Fps is expressed specifically in epithelial cells. Examination of Fps during different mammary stages has shown that expression begins to increase during pregnancy and reaches maximal levels during lactation. An upregulation of Fps tyrosine kinase activity displays a similar profile. This would suggest that Fps might regulate epithelial cell differentiation. However, morphological and histological analyses could not detect any obvious differences in the pattern or quantity of alveolar structures between wildtype and knockout mice. Examination of ducts during lactation indicates that knockout cells may have a distorted shape with respect to their apical surface being more extended into the lumen of the duct. The exact nature of this potential phenotype has not yet been fully characterized but it suggests that Fps may regulate an aspect of lactation
Signal Transduction in Regulation of Autocrin HGF Expression in Breast Cancer Metastasis( )

4 editions published between 1999 and 2003 in English and held by 0 WorldCat member libraries worldwide

Increased expression of HGF and its receptor Met in breast cancer has been identified as a possible independent predictor of recurrence in breast cancer patients. In contrast, most non-malignant epithelial cells express Met but not HGF. Thus, the change in regulation of HGF expression may be a key step in breast cancer progression. In this project, Dr. Hung has demonstrated a co-operative effect of c-Src and Stat3 in the activation of HGF expression in carcinoma as well as epithelial cells. Changes in c-Src kinase activation affect Stat3 activity through its tyrosine phosphorylation and DNA binding activity to specific Stat3 consensus sites on the HGF promoter. These results suggest tumor specificity in the transcriptional regulation of HGF expression in carcinoma cells, and could thus lead to novel strategies for the design of low molecular weight antagonists to inhibit tumor metastasis. Dr. Hung departed from this laboratory to take up a new position at the Sunnybrook Health Science Centre, University of Toronto. This PDF training award has recently been modified to extend the term, without any additional lands, from 1 July 0 1 to 1 July 02. All other terms and conditions of this award remain the same. There is no new progress since the last annual report was filed. We are aggressively recruiting for a new candidate for this PDF position
Analysis of HRAD1, a Human G2 Checkpoint Control Gene( )

3 editions published between 1999 and 2002 in English and held by 0 WorldCat member libraries worldwide

The purpose of this research is to determine the role of the hRAD1 gene in breast cancer. The research includes the generation and analysis of cell lines lacking hRAD1. The analysis includes an assessment of checkpoint proficiency and genomic instability in these cells. The research also includes a biochemical characterization of the hRAD1 protein, including its subcellular localization and protein-protein interactions with other checkpoint proteins. These other checkpoint proteins include BRCA1, hHUSl, and hRAD9. hRAD1 does not interact with BRCA1 but does form a complex with hHUS1 and hRAD9
The Role of Fps in Tumor-Associated Angiogenesis( )

3 editions published between 2002 and 2004 in English and held by 0 WorldCat member libraries worldwide

Fps and Fer are members of a unique family of cytoplasmic tyrosine kinases. Transgenic expression of Fps in mice (fps(exp MF)) gave rise to hyper-vascularity and multi-focal hemangiomas implicating this kinase in angiogenic regulation. This phenotype suggested that tumorigenesis and metastases may be promoted in these mice and conversely, inhibited in fps loss-of-function mice. Surprisingly, we observed early onset of tumors in fps loss-of-function mice (relative to wild type) suggesting that Fps has a tumor suppressor-like function. Characterization of the vessels in fps(exp MF) mice showed that their vessels were leaky, and that vascularity was increased approximately 1.7-fold. In addition, it was shown that the vascular defects in these mice correlated with VFGF- and PDGF-activation of gain-of-function Fps in endothelial cells. Numerous hematological and hemostatic defects associated with the angiogenic phenotype were also observed. Interestingly, these abnormalities were reminiscent of Kasabach Merritt Syndrome and disseminated intravascular coagulation. Collectively, these data suggested that the vascular abnormalities in fps(exp MF) mice are a result of a defect/delay in vascular maturation. As well, they suggest that Fps influences the processes of angiogenesis and hemostasis through regulatory effects on the endothelium
Studies on Platelet-Derived Growth Factor Beta-Receptor and Hepatocyte Growth Factor Receptor c-met in Paracrine Interactions in Human Breast Cancer( )

2 editions published between 1995 and 1996 in English and held by 0 WorldCat member libraries worldwide

Platelet-derived growth factor (pDGF) and hepatocyte growth factor (HGF) are key regulators of breast stromal- epithelial interactions. We examined the expression of PDGF 13-receptor, HGF receptor/Met and the corresponding ligands in primary human breast cancer using in situ hybridization and imunohistochemical techniques. The results showed that PDGF 13-receptor was localized in smooth musclie-actin-positive cells and vascular endothelial cells in the periepithelial stroma, but not in the epithelial component of ductal carcinoma in situ. These findings support the notion that PDGF BB, which is produced by breast carcinoma cells, functions in the paracrine stimulation of the stroma by adjacent carcinoma cells. In contrast, HGF receptor/Met was exclusively expressed on nonmalignant and malignant epithelial cells. However, HGF mRNA was expressed in both stromal cells and in carcinoma cells in regions of invasive cancer; these results. suggest that both paracrine and autocrine stimulation by HGF of mammary carcinoma cells can occur. Our hypothesis is that co-expression of HGF and HGF receptor/Met results in the establishment of an HGF autocrine loop which provides a selective advantage for autonomous growth and metastasis of mammary carcinoma cells. To further investigate the possible role of an HGF autocrine loop in the progression of breast cancer, we are currently examining expression and function of HGF in human and murine primary breast carcinomas and carcinoma cell lines
 
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English (36)