WorldCat Identities

阿部稔哉

Overview
Works: 7 works in 7 publications in 2 languages and 10 library holdings
Genres: Anecdotes  History 
Publication Timeline
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Most widely held works by 阿部稔哉
Shūmatsu okinawa de chotto yururi by Yūji Shimokawa( Book )

1 edition published in 2014 in Japanese and held by 4 WorldCat member libraries worldwide

Shumatsu chotto dipu na taitabi by Yūji Shimokawa( Book )

1 edition published in 2017 in Japanese and held by 1 WorldCat member library worldwide

Shumatsu taiwan de chotsuto hitoiki by Yūji Shimokawa( Book )

1 edition published in 2013 in Japanese and held by 1 WorldCat member library worldwide

Shumatsu betonamu de chotto ippuku by Yūji Shimokawa( Book )

1 edition published in 2014 in Japanese and held by 1 WorldCat member library worldwide

Afuganisutan : Sabaku to ennetsu to senran to hitobito by Yūji Shimokawa( Book )

1 edition published in 2002 in Japanese and held by 1 WorldCat member library worldwide

Shumatsu bankoku de chotto datsuryoku by Yūji Shimokawa( Book )

1 edition published in 2013 in Japanese and held by 1 WorldCat member library worldwide

Basement membrane destruction by pancreatic stellate cells leads to local invasion in pancreatic ductal adenocarcinoma( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Abstract: Stroma invasion is an important step in pancreatic cancer progression. However, how pancreatic ductal adenocarcinoma (PDAC) with ductal structure invades the surrounding stroma has not been clear. Here, we elucidated the mechanism of stromal invasion of PDAC, using organoids. From resected PDAC specimens, we established human PDAC organoids, which developed ductal and basement membrane (BM) structures. When the organoids were co-cultured with pancreatic stellate cells (PSCs) in a collagen matrix, organoids lost their BM and ductal structures, and invaded collagen matrix more frequently than did mono-cultured organoids. Interestingly, direct contact by PSCs to PDAC organoids was observed before BM destruction. Matrix metalloproteinase (MMP) 2 or membrane type-1 MMP (MT1MMP) knockdown in PSCs significantly attenuated BM destruction by PSCs, and retained the ductal structures in organoids. Our results imply that direct contact by PSCs induces BM destruction and stromal invasion of PDAC via MMP2 which binds to MT1MMP on PSCs. Highlights: Pancreatic ductal carcinoma (PDAC) organoid reconstruct basement membrane (BM). Pancreatic stellate cells (PSCs) induced BM destruction of PDAC organoid. BM destruction of PDAC organoids is induced by direct contact of PSCs. MMP2 and MT1MMP expression in PSCs induced BM destruction of PDAC organoid
 
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Audience Level
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  Kids General Special  
Audience level: 0.85 (from 0.75 for Shūmatsu ... to 0.93 for Shumatsu b ...)

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