WorldCat Identities

Bay, William W.

Overview
Works: 6 works in 6 publications in 1 language and 7 library holdings
Genres: Academic theses 
Classifications: SF997.5.D4,
Publication Timeline
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Most widely held works by William W Bay
A study of the vascular lesions of malignant catarrhal fever in deer by histopathology, electron microscopy, and immunofluorescence by Keith Allen Clark( Book )

1 edition published in 1975 in English and held by 2 WorldCat member libraries worldwide

The lesions of malignant catarrhal fever (MCF) were studied in arteries, choroid plexus, and renal glomeruli of spontaneously affected and experimentally-infected deer by light microscopy, electron microscopy, and immunofluorescence microscopy. Serum beta and gamma globulin levels were quantitated and compared to those of normal deer. Microscopic lesions were detected in vessels of many tissues, with kidneys, pancreas, lymph nodes and testes being most frequently involved. The arterial lesions consisted of segmental degenerative, necrotizing, and exudative inflammatory changes in the walls of affected arteries and arterioles. The lesions in choroid plexus and renal glomeruli were of an exudative inflammatory nature. Ultrastructural lesions paralleled those observable by light microscopy, with the significant exception of the presence of numerous viral particles apparently replicating in endothelial cells of affected arteries, choroid plexus, and renal glomeruli. These particles were also present in epithelial cells of the choroid plexus and in epithelial cells of the renal glomeruli. The viral particles were considered to belong to the Togavirus family on the basis of size, morphology, and apparent mode of replication. Immunofluorescence revealed an antigen common to all affected deer in endothelial cells and in the walls of affected vessels, as well as in renal glomeruli. Gamma globulin was also demonstrated by immunofluorescence in the same areas. Fibrin (or fibrinogen) was present in fewer locations, and was distributed in a somewhat different (random) pattern. The results of this study suggest that MCF in deer is caused by a virus which is morphologically similar to the togaviruses, and that humoral immune mechanisms participate in the development of the vascular lesions, probably as an immune complex vasculitis
Subacute Toxicity Study in Swine( Book )

1 edition published in 1970 in English and held by 1 WorldCat member library worldwide

The simultaneous oral administration of chloroquine, primaquine, and D.F.D. did not produce clinically detectable changes or gross or microscopic lesions in pigs. The only consistent change observed in the study was an increase in methemoglobin concentration. Keywords: Subacute toxicity study, Toxicology, Hematologic and biochemical blood valves, Methemoglobin concentration, U/A Reports. (JG)
Toxicity testing of antimalarial drugs in swine and dogs( Book )

1 edition published in 1969 in English and held by 1 WorldCat member library worldwide

Acute, subacute, and chronic toxicity studies and photosensitization studies were conducted in swine and dogs using antimalarial compounds singularly or in combination. The subcutaneous administration of WR-9838-B, 5 mg/kg or 10 mg/kg, for 15 consecutive days resulted in clinical manifestations of lameness, loss of weight and appetite, ocular involvement and swelling at injection sites. The oral administration of WR 40,070 for 28 consecutive days resulted in clinical manifestations of vomition, excessive salivation and hyperirritability. Healthy purebred beagle dogs were given a combination of chloroquine and trimethoprim orally in an 'Acute Minimum Lethal Dose Study' and in a 'Subacute Toxicity Study.' The symptoms observed included emesis, depression, incoordination, ataxia, convulsions and death. The minimum amount of the following antimalarial compounds required to consistently produce phototoxicity in white swine, when four doses were administered orally during 44 hours of U.V. light exposure was: quinine sulfate, 25 mg/kg; WR-7930, 15 mg/kg; and WR-30090, 25 mg/kg. Specific-pathogen-free swine were given a combination of chloroquine, primaquine, and D.F.D. orally, twice weekly for four weeks
The lymphoreticular response of intact and immunologically altered dogs to infection with Ehrlichia canis by Michael James Reardon( Book )

1 edition published in 1977 in English and held by 1 WorldCat member library worldwide

The lymphoreticular response of dogs to Ehrlichia canis infection was studied in immunocompetent dogs (Group I) and in dogs after immunosuppressive therapy with cyclophosphamide (Group II) or antilymphocyte serum (Group III). Immunosuppression did not increase the mortality rate nor did it prevent the clinical manifestations of acute ehrlichiasis. Anorexia, pyrexia, weight loss and mucopurulent ocular-nasal discharge were consistent features of the acute infection. Hypergammglobulinemia was consistently observed in Group I principals but was less pronounced in Group II principals and absent in the principals of Group III. A similar trend was observed in anti-E. canis IFA titers although very low titers were observed in some Group III principals. Gross lesions consisted of heavy dense lungs, slightly pale livers, splenomegaly and an increased amount of red, active-appearing long bone marrow in Group I principals. Only the red active-appearing long bone marrow was prominent in the other groups. Hemorrhagic cystitis due to cyclophosphamide was observed in all Group II dogs. Previously unreported microscopic lesions observed in Group I principals were marked hyperplasia of the thymic dependent areas of spleen and lymph nodes, parafollicular splenic hemorrhages, phlebitis and perivasculitis in the renal cortex involving especially the stellate veins and proliferative RE nodules in the liver causing necrosis of adjacent hepatocytes. Group II and III principals had less severe lesions and those that occurred appeared later in the course of the disease
Toxicity Testing of Antimalarial Drugs in Swine. I.A Study of Quinine Sulfate Toxicity( Book )

1 edition published in 1967 in English and held by 1 WorldCat member library worldwide

Quinine sulfate administered orally to swine in doses of 361 mg/kg/day (milligrams/kilograms/day) resulted in an LD 100/10 (Lethal dose 100/10), whereas, 180 mg/kg/day produced death in one of four pigs in 30 days, and no ill effects were observed in animals that received 45 mg/kg/day for 30 days. The most consistent symptoms observed were: emesis, depression, ataxia, partial to complete loss of sight and convulsions. The hematologic and biochemical results were very unimpressive, with few changes. The significant gross lesions may be summarized as: a hemorrhagic disorder, corneal lesions and alopecia. The most significant microscopic lesions are vacuolization of neurons, corneal lesions, bone marrow lesions and degenerative lesions of the arteriolar walls. Keywords: U/A Reports, Toxicity, Antimalarial, Drugs, Swine, Testing, Pharmacology, Quinine sulfate, Medical research. (jg)
 
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