WorldCat Identities

Butelman, Eduardo R.

Works: 4 works in 4 publications in 1 language and 6 library holdings
Roles: Other, Contributor
Publication Timeline
Most widely held works by Eduardo R Butelman
Neurocognitive and neuroinflammatory correlates of PDYN and OPRK1 mRNA expression in the anterior cingulate in postmortem brain of HIV-infected subjects by Vadim Yuferov( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

Adolescent oxycodone self administration alters subsequent oxycodone-induced conditioned place preference and anti-nociceptive effect in C57BL/6J mice in adulthood( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract: Adolescent and young adult abuse of short-acting MOP-r agonists such as oxycodone is a pressing public health issue. Few preclinical studies have examined how adolescent exposure to oxycodone impacts its effects in the transition to adulthood. Objective: To determine in mice how chronic adolescent oxycodone self-administration (SA) affects subsequent oxycodone-induced conditioned place preference (CPP), locomotor activity, and anti-nociception once mice reach early adulthood. Methods: Adolescent C57BL/6J male mice (4 weeks old, n=6-11) and adult mice (10 weeks old, n=6-10) were surgically implanted with indwelling jugular catheters. Mice then acquired oxycodone self-administration (14 consecutive 2-hr daily sessions; 0.25mg/kg/infusion) followed by a 14-day drug-free (withdrawal) period in home cage. After the 14-day drug-free period, mice underwent a 10-day oxycodone CPP procedure (0, 1, 3, 10mg/kg i.p.) or were tested for acute oxycodone-induced antinociception in the hot plate assay (3.35, 5, 7.5mg/kg i.p.). Results: Mice that self-administered oxycodone during adolescence exhibited greater oxycodone-induced CPP (at the 3mg/kg dose) than their yoked saline controls and mice that self-administered oxycodone during adulthood. Oxycodone dose-dependently increased locomotor activity, but sensitization developed only to the 3mg/kg in the mice that underwent oxycodone self-administration as adolescents. Mice that self-administered oxycodone as adolescents decreased in the anti-nociceptive effects of oxycodone in one dose (5mg/kg), whereas animals that self-administered oxycodone as adults did not show this effect. Conclusion: Chronic adolescent oxycodone self-administration led to increased oxycodone-induced CPP (primarily 1 and 3mg/kg, i.p.) and reduced antinociceptive effect of oxycodone (5mg/kg, i.p.) in adulthood. Highlights: Adolescent oxycodone SA enhanced 1 and 3 mg/kg oxycodone-induced CPP in early adulthood. Adolescent oxycodone SA resulted in a sensitization of locomotor activity induced by 3 mg/kg oxycodone in early adulthood. Adolescent oxycodone SA led to tolerance in oxycodone (5 mg/kg)-induced nociception in early adulthood
Strain and cocaine-induced differential opioid gene expression may predispose Lewis but not Fischer rats to escalate cocaine self-administration( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract: The aim of the present study was to investigate alterations in gene expression of opioid system components induced by extended access (18h) cocaine self-administration and to determine the impact of genetic background in the vulnerability to escalate cocaine intake. Comparing two inbred rat strains, we previously reported that Lewis rats progressively escalated cocaine consumption compared to Fischer rats, in a new translational model of intravenous cocaine self-administration, which included 14 sessions of 18-h operant sessions in which rats were allowed to select the cocaine unit dose to self-administer. We compare here Fischer and Lewis rats in the gene expression of endogenous opioid peptides (Pomc, Penk, Pdyn) and cognate receptors (Oprm, Oprk and Oprd) in reward-related brain regions, after exposure to either cocaine self-administration or yoked-saline, in the aforementioned translational paradigm. We performed a correlation analysis between the mRNA level, found in the Dorsal Striatum (DS), Nucleus accumbens (NAcc) shell and core respectively, and individual cocaine intake. Our findings show that the gene expression of all the aforementioned opioid genes exhibit strain-dependent differences in the DS, in absence of cocaine exposure. Also, different strain-specific cocaine-induced mRNA expression of Oprm and Oprk was found in DS. Only few differences were found in the ventral parts of the striatum. Moreover, gene expression level of Pdyn, Penk, Oprk, and Oprm in the DS was significantly correlated with cocaine intake only in Fischer rats. Overall, these data shed light on potential genetic differences which may predispose of subjects to initiate and escalate cocaine consumption. Highlights: Lewis, but not Fischer rats, escalate cocaine intake during 14 extended access (18 h) self-administration sessions. Cocaine-induced gene expression changes were observed primarily in the dorsal, but not the ventral, part of the striatum. Strain differences were observed in basal striatal level of Pomc, Pdyn, Penk, Oprm, Oprk, and Oprd mRNA. mRNA level of Pdyn and Oprk, in the Dorsal Striatum correlates with individual cocaine intake selectively in Fischer rats
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Audience level: 0.94 (from 0.88 for Adolescent ... to 0.97 for Neurocogni ...)