WorldCat Identities

Gabriel, Kathleen

Works: 8 works in 9 publications in 2 languages and 12 library holdings
Genres: Criticism, interpretation, etc  Fiction  Detective and mystery television programs  Television programs  Animated television programs  Romance fiction  Posters  Music 
Roles: Author
Classifications: PR4624, 016.823912
Publication Timeline
Most widely held works by Kathleen Gabriel
R.O.D. the TV : we are the Paper Sisters Detective Company( Visual )

in Japanese and held by 3 WorldCat member libraries worldwide

Three girls named Anita, Michelle and Maggie are hired to protect Japanese author Nenene Sumiregawa during her stay in Hong Kong. In an incident where the "Paper Sisters" save Nenene from a disgruntled author, Nenene discovers that the sisters have the capability to control paper at their own will - an ability once used by her long-lost friend Yomiko "The Paper" Readman. Arriving in Japan after an airliner incident, the Paper Sisters move into Nenene's apartment and become her freeloading bodyguards
The Baker Street briefs : being the writings of S. Tupper Bigelow, BSI "The five orange pips" by S. Tupper Bigelow( Book )

2 editions published between 1994 and 2000 in English and held by 2 WorldCat member libraries worldwide

"A delightfully and hopefully complete selection of the Sherlockian writings of Canada's first Baker Street Irregular. Judge Bigelow's collection of Sherlockiana formed the nucleus of the Arthur Conan Doyle Collection which now resides at the Metropolitan Toronto Reference Library."--Title page verso
Kansas connection / by Kathleen Gabriel by Kathleen Gabriel( Book )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Bigelow on Holmes : an index to the writings upon the writings about Mr. Sherlock Holmes by Metropolitan Toronto Central Library( Book )

1 edition published in 1974 in English and held by 1 WorldCat member library worldwide

A concert of the music enjoyed by Sherlock Holmes and Dr Watson : presented at the Arts & Letters Club of Toronto, Wednesday 17 April 1985 by David Skene Melvin( Book )

1 edition published in 1985 in English and held by 1 WorldCat member library worldwide

Metropolitan Toronto Reference Library( Visual )

1 edition published in 1987 in English and held by 1 WorldCat member library worldwide

Stage management of "Pains of youth," a play by Ferdinand Bruckner by Kathleen Gabriel( )

1 edition published in 1998 in English and held by 1 WorldCat member library worldwide

Regulation of the tumour suppressor PTEN through exosomes by Kathleen Gabriel( )

1 edition published in 2013 in Undetermined and held by 0 WorldCat member libraries worldwide

<p>PTEN is a potent tumour suppressor protein. Aggressive and metastatic prostate cancer (PC) is associated with a reduction or loss of PTEN expression. PTEN reduction often occurs without gene mutations, and its downregulation is not fully understood. Herein, we show that PTEN is incorporated in the cargo of exosomes derived from cancer cells, and this is an exclusive characteristic of cancer cells; normal cells do not incorporate PTEN in their exosomes. We found that this process is affected by the expression of oncogenes, with activation of oncogenic molecules leading to increased PTEN incorporation into exosomes. PTEN expressed in exosomes can be transferred to other cells that have a reduction or loss of PTEN expression. The transferred PTEN is active, as cells showed a substantial increase in phosphatase activity upon treatment with PTEN-bearing exosomes. PTEN transferred through exosomes is also competent to confer tumour-suppression activity to acceptor cells. After incubation with PTEN-bearing exosomes, recipient cells exhibited decreased AKT phosphorylation, changes in the expression of cell cycle mediators indicating cell cycle arrest, and decreased proliferation. These data suggest that exosomal PTEN may be able to compensate for PTEN loss in cancer cells, by transferring the active protein to cancer cells where it can then perform its role as a tumour suppressor.</p>
Audience Level
Audience Level
  Kids General Special  
Audience level: 0.43 (from 0.10 for R.O.D. the ... to 0.95 for Regulation ...)