WorldCat Identities

Golding, G. Brian

Works: 5 works in 5 publications in 1 language and 5 library holdings
Classifications: QH307.2,
Publication Timeline
Most widely held works by G. Brian Golding
Lateral gene transfer in bacteria by Weilong Hao( )

1 edition published in 2007 in English and held by 1 WorldCat member library worldwide

Lateral gene transfer has been well known as an important force in bacterial evolution. A substantial number of genes can be inserted into or deleted from genomes through the process of lateral transfer. Detecting or inferring gene insertions/deletions is of interest because such information provides insights into bacterial genome evolution and speciation. However, efficient inference of genome events is difficult because genome comparisons alone do not generally supply enough information to distinguish insertions, deletions, and other rearrangements. The goal of my thesis was to gain a clear picture of the gene insertions/deletions during bacterial genome evolution. Parsimony and maximum likelihood methods were employed to infer gene insertions/deletions. A higher rate of gene turn-over was found in the recent branches of the phylogenetic trees, suggesting that recently transferred genes tend to be deleted rapidly during evolution. The measurement of the evolutionary rates of the recently transferred genes shows that recently transferred genes are likely under accelerated evolution. It is also evident that some recently transferred genes might have an adaptive role to their hosts. After that, the maximum likelihood model was improved by incorporating rate variation. The estimation of the improved model reveals that there is a high level of rate variation for gene insertions/deletions. The degree of rate variation remained high even after informational genes were excluded from the analysis. Furthermore, gene location was examined and the results showed that many recently transferred genes tend to be trans-positioned and be deleted. The studies of this thesis present a comprehensive picture of recently transferred genes in bacterial genome evolution
Studies of the molecular evolution of COI by Melanie Lou( Book )

1 edition published in 2007 in English and held by 1 WorldCat member library worldwide

Structural determinants of replacement rate heterogeneity by Frances Raftis( Book )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

Structure, function, and evolution of protein repeats by Melanie Huntley( )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

Protein sequences are not a random arrangement of amino acid residues. Historical and functional constraints are among the many forces governing the composition of protein sequences. This thesis examines the peculiar feature of repetitive sequence within proteins. Previously thought to be of little or no importance, protein repeats are beginning to reveal themselves as significant functional and evolutionary entities. We challenge previous assumptions about the function of proteins containing repeats by demonstrating that neurological proteins are not enriched with repeats. We do, however, find that repeats abound within developmental proteins. To better understand the primary structure and evolution of protein repeats, helping to elucidate the function of these regions, we test an existing repeat detection method but find it inadequate. We then develop a novel method which detects repeats within a sequence by inferring a history of repeat producing events. This is the first method to detect repeats within biological sequence that utilizes a model of repeat evolution to facilitate repeat detection. Finally we concentrate our efforts on the molecular evolution of protein repeats, and find evidence supporting some repeats as functionally important sequence features that are conserved by selection
Modeling the rate of lateral gene transfer in bacillaceae genomic evolution by Danya Konrad( Book )

1 edition published in 2008 in English and held by 1 WorldCat member library worldwide

Audience Level
Audience Level
  Kids General Special  
Audience level: 0.70 (from 0.64 for Structural ... to 0.79 for Lateral ge ...)