WorldCat Identities

Hanson, William L.

Overview
Works: 12 works in 21 publications in 1 language and 24 library holdings
Genres: Sources  Archives  Handbooks and manuals  History  Academic theses 
Roles: Author
Classifications: KFW2926.S4,
Publication Timeline
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Most widely held works by William L Hanson
Testing of Experimental Compounds for Efficacy against Leishmania( Book )

6 editions published between 1986 and 1990 in English and held by 6 WorldCat member libraries worldwide

A total of 298 compounds were studied in the primary visceral test system for suppressive activity against Leishmania donovani in golden hamsters. Twenty-nine of these compounds were noted to have some suppressive activity. The activity of 5 was approximately equal to that of the reference compound, glucantime. Two others (sinefungin and BL11864) had activity considerably greater than that of glucantime (Glucantime Index ranged from 4.04 - 30.2 and 8.13 respectively). A comparison of the antileishmanial efficacy of WR06026 and eight of its metabolites against L. donovani revealed that four of the metabolites were active. However, none of the metabolites were as active as WR06026. The efficacy of six selected compounds wa compared against L. donovani in hamsters. The results indicated that the antileishmanial activity of WR06026> sinefungin> amphotericin B> glucantime> 9-deazainosine> pentamidine. A total of 88 compounds were evaluated in the primary cutaneous system for suppressive activity against cutaneous lesions resulting from Leishmania braziliensis panamensis in golden hamsters. Five of these compounds were active (greater than 50% suppression of lesions). The activity of three of these compounds was equal to or greater than that of the reference compound, glucantime (Glucantime Indexed ranged from at least 2.58 to 30.2)
Study of Compounds for Activity against Leishmania( )

3 editions published between 1990 and 1994 in English and held by 3 WorldCat member libraries worldwide

During the period covered by this report, a total of 75 compounds were tested for efficacy against Leishmania donovani infections in hamsters. A computer analysis of the data from the study of approximately 6000 compounds tested since this project was initiated in 1974 suggested a number of compounds with sufficient promise to warrant further study during this contract period. The 8-aminoquinolines were the most active compounds studied, one of which was 100% suppressive at dosage levels as low as 13mg/kg. Six phenanthrene methanols as well as two dibenzopyrroles selected for study were not highly active against L. donovani, and some were toxic
Chemotherapy of Leishmaniasis( Book )

3 editions published between 1983 and 1984 in English and held by 3 WorldCat member libraries worldwide

Three day infections of Leishmania donovani in the golden hamster (primary visceral test system) were used to test a total of 581 compounds (564 new compounds and 17 requiring additional testing) or antileishmanial activity against visceral leishmaniasis and 19 day infections of L. braziliensis panamensis in the golden hamster (primary cutaneous test system) were used to test a total of 21 compounds for activity against cutaneous infections. One hundred and fifty-six of the 581 compounds tested in the primary visceral test system were observed to have significant suppressive activity against L. donovani at one or more drug dosage levels. A total of 41 of these active compounds had significant suppressive activity to warrant the calculation of the Glucantime Index. Twenty-four of these had suppressive activity greater than the reference compound, Glucantime, 10 had activity equivalent to that of Glucantime, while seven had activity less than Glucantime. Nine of the 21 compounds tested in the primary cutaneous test system were noted to have significant suppressive activity against L. braziliensis panamensis at one or more drug dosage levels. Two of these active compounds had sufficient antilesishmanial activity to warrant the calculation fo a Glucantime Index. The activity of these two compounds was similar to that of Glucantime. Extensive studies were carried out with formycin B, WR 6026, WR238605, and Glucantime to investigate further the optimum treatment regimen. Keywords: Antimony resistance; Primaquine resistance; Owl monkeys; Optimization studies; Curative studies; Data processing; and Dogs
Special education teacher knowledge of the purpose of education in a culture of liberty by William L Hanson( )

1 edition published in 2003 in English and held by 2 WorldCat member libraries worldwide

Report writing manual by Dane County (Wis.)( Book )

1 edition published in 1991 in English and held by 2 WorldCat member libraries worldwide

Alliance for Conscientious Objectors records by Alliance for Conscientious Objectors (U.S.)( )

in English and held by 2 WorldCat member libraries worldwide

Articles of incorporation of the Alliance for Conscientious Objectors (1972), correspondence, memoranda, briefs and related legal documents, financial statements, files of regional branches, files on other organizations, surveys, newsletters, and clippings, relating to the organization's program to improve the general welfare of conscientious objectors and end legal and social discrimination against them, including securing veterans benefits for conscientious objectors who performed two years of civilian service in lieu of induction into the military. Includes correspondence from other conscientious objectors organizations including Central Committee for Conscientious Objectors, Conscientious Objectors for Equal Treatment, Committee for Equality for All Draftees, and National Interreligious Service Board for Conscientious Objectors. Correspondents include Paul Anderson, Lillian Baker, Lawrence L. Curtice, Bruce Comly French, Bruce Friedman, William Gerber, Paul N. Halvonik, William L. Hanson, Edward A. Harter, Robert L. Ness, Peter Sly, Barry Charles Spatz, Gill J. Thomas, James L. Vonasch, Allan F. Wichelman, and Raymond Orson Wright
Evaluation of Potential Antileishmanial Drugs in Animal Models( )

1 edition published in 1997 in English and held by 1 WorldCat member library worldwide

A total of 16 selected compounds which included some natural products as well as drugs known to be efficacious against other diseases were studied at various dosage levels and via various routes of administration in hamsters for antileishmanial efficacy against visceral leishmaniasis (Leishmania Leishmania donovani) and three of the same compounds were studied for activity against cutaneous leishmaniasis (Leishmania Vianni panamensis). None of these were efficacious against either leishmania but several were toxic to the host. Leishmanial cutaneous lesion development in golden hamsters is very helpful, along with other procedures, for the confirmation of the presence of Leishmania in cultures obtained by WRAIR from patients with suspected infections with these parasites. The infection of golden hamsters with several species of Leishmania of human origin (identified in other laboratories by biochemical typing as Leishmania Viannia panamensis, Leishmania Leishmania mexicana, and Leishmania Viannia braziliensis) resulted in clinical disease similar to that seen in human beings. Thus a laboratory animal model is now in place for the performance of drug sensitivity studies on these new isolates of Leishmania, some of which apparently had various degrees of susceptibility to current therapeutic drugs
Testing of Experimental Antileishmanial Compounds( )

1 edition published in 1994 in English and held by 1 WorldCat member library worldwide

Six plant derivatives which were selected for in vivo study because of their in vitro antiLeishimanial activity and low toxicity were studied for activity against Leishmania Leishmania donovani and Leishmania Viannia brazitiensis in hamsters. The time interval between completion of treatment and evaluation of results was extended up to 4-6 weeks to evaluate any possible delayed antiLeishmanial activity by the compounds. None of the compounds studied were active in hamsters against either species of Leishmenia. Extension of time between treatment and evaluation of results did not increase the in vivo activity of any of the compounds studied. None of the compounds studied were toxic based on body weight toss, mortality, or clinical signs
Plasmodium berghei infection in neonatally thymectomized hamsters by Willie L Chapman( Book )

1 edition published in 1971 in English and held by 1 WorldCat member library worldwide

ACLU position paper on conscription by William L Hanson( Book )

1 edition published in 1972 in English and held by 1 WorldCat member library worldwide

Evaluation of Antileishmanial Drugs in Animal Models( )

1 edition published in 2000 in English and held by 1 WorldCat member library worldwide

A total of 34 selected compounds, including natural products, some compounds known to be efficacious against other diseases, cholesterol lowering drugs currently in use in human beings, and pro drugs of the pentamidine type were studied in hamsters at various dosage levels, via various routes and treatment schedules for antileishmanial efficacy against Leishmania (leishmania) donovani. One of the same compounds (Baycol) was studied for efficacy against Leishmania (Viannia) panamensis and leishmania ma%or and three other compounds were studied for efficacy against leishmania (V%.) panamensis. Only two of these compounds had any efficacy against visceral leishmaniasis (BN97515 and an analog of Amphotericin B). The activity of the Amphotericin B analog was not as great as Amphotericin B and BN97515 was active but toxic. None were active against cutaneous leishmaniasis. Several topical ointment preparations (containing the same drug but different water concentrations) were highly efficacious in mice against cutaneous lesions caused by leishmania major. When biopsy cultures obtained by WRAIR from human and canine patients with suspected infections with Leishmania were injected into hamsters and/or mice via various routes, the presence of cutaneous leishmaniasis was confirmed in 38 human patients and the presence of visceral leishmaniasis was confirmed in 8 other patients (5 human beings and 3 canines)
Improved Therapy of Leishmaniasis by Encapsulation of Antimonial Drug in Biodegradable Artificial Phospholipid Vesicles (Liposomes)( Book )

1 edition published in 1978 in English and held by 1 WorldCat member library worldwide

 
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Audience level: 0.91 (from 0.69 for Plasmodium ... to 0.99 for Testing of ...)

Languages
English (21)