WorldCat Identities

Kitazawa, Yusuke

Overview
Works: 4 works in 4 publications in 1 language and 7 library holdings
Roles: Contributor, Other
Publication Timeline
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Most widely held works by Yusuke Kitazawa
Anatomical basis for simultaneous block of greater and third occipital nerves, with an ultrasound-guided technique by Ken Kariya( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Direct evidence for activated CD8+ T cell transmigration across portal vein endothelial cells in liver graft rejection by Taro Kariya( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Expression of area-specific M2-macrophage phenotype by recruited rat monocytes in duct-ligation pancreatitis by Enqiao Yu( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Abstract Donor-specific blood transfusion is known to induce alloresponses and lead to immunosuppression. We examined their underlying mechanisms by employing fully allogeneic rat combinations. Transfused recipients efficiently produced alloantibodies of the IgM and IgG subclasses directed against donor class I MHC. The recipients exhibited active expansion of CD4 T cells and CD4FOXP3 regulatory T cells (Treg cells), followed by CD45R B cells and IgM or IgG subclass antibody-forming cells mainly in the spleen. From 1.5 days, the resident MHCIICD103 dendritic cells (DCs) in the splenic T-cell area, periarterial lymphocyte sheath, formed clusters with recipient BrdU or 5-ethynyl-2′-deoxyuridine cells, from which the proliferative response of CD4 T cells originated peaking at 3-4 days. Transfusion-induced antibodies had donor passenger cell-depleting activity in vitro and in vivo and could suppress acute GvH disease caused by donor T cells. Furthermore, Treg cells significantly suppressed mixed leukocyte reactions in a donor-specific manner. In conclusion, single blood transfusion efficiently induced a helper T-cell-dependent anti-donor class I MHC antibody-forming cell response with immunoglobulin class switching, and a donor-specific Treg cell response mainly in the spleen, probably by way of the indirect allorecognition via resident DCs. These antibodies and Treg cells may be involved, at least partly, in the donor-specific transfusion-induced suppression of allograft rejection
 
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Audience level: 0.96 (from 0.88 for Anatomical ... to 0.97 for Anatomical ...)

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