WorldCat Identities

Krueger, J. M.

Works: 3 works in 5 publications in 1 language and 5 library holdings
Publication Timeline
Most widely held works by J. M Krueger
Peptidoglycans as Promoters of Slow-Wave Sleep. I. Structure of the Sleep-Promoting Factor Isolated from Human Urine( Book )

3 editions published in 1984 in English and held by 3 WorldCat member libraries worldwide

The structures of components of the sleep-promoting material purified from human urine were established by fast atom bombardment-mass spectrometry. We report here that two substances isolated from that preparation, viz. N-acetylglucosaminyl-1,6-anhydro-N-acetylmuramyl-Ala-gamma-Glu-diaminopimelyl-Ala) and that compound lacking the terminal alanine, are active as somnogens. Cerebro-intraventricular administration of 1 pmol of the glycotetrapeptide was sufficient to induce prolonged excess sleep in rabbits. Findings show that in addition to the muramyl form of peptidoglycan monomers, the anhydro muramyl form, with no reducing end, is compatible with somnogenic activity. Furthermore, the data obtained with a natural product amplify our earlier observations with smaller synthetic molecules of the importance of amidation/deamidation in the structure-activity relationships of muramyl peptides
Sleep-Promoting Factor S: Purification and Properties( Book )

1 edition published in 1978 in English and held by 1 WorldCat member library worldwide

Sleep-Promoting Material from Human Urine and Its Relation to Factor S from Brain( Book )

1 edition published in 1979 in English and held by 1 WorldCat member library worldwide

Audience Level
Audience Level
  Kids General Special  
Audience level: 0.99 (from 0.99 for Peptidogly ... to 0.99 for Peptidogly ...)