WorldCat Identities

Nieri, Paola

Overview
Works: 53 works in 53 publications in 2 languages and 53 library holdings
Roles: Author
Publication Timeline
.
Most widely held works by Paola Nieri
Influenze genetiche e sostanze di abuso : tesi di laurea by Francesco Cioni( Book )

1 edition published in 1998 in Italian and held by 1 WorldCat member library worldwide

Analisi di funzioni cellulari su microstrutture polimeriche per applicazioni nel campo dell'ingegneria tissutale : tesi di laurea by Michela Simonetti( Book )

1 edition published in 2002 in Italian and held by 1 WorldCat member library worldwide

NO : una molecola con funzioni di messaggero fisiologico : tesi di laurea by Patrizia Vecoli( Book )

1 edition published in 1995 in Italian and held by 1 WorldCat member library worldwide

Basi fisiopatologiche e trattamento farmacologico della depressione : tesi di laurea by Claudia Iozza( Book )

1 edition published in 2002 in Italian and held by 1 WorldCat member library worldwide

Allosteric modulation of adenosine A1 and A2A receptors by substituted thiadiazoles : tesi di laurea by Daniele Pietra( Book )

1 edition published in 2002 in English and held by 1 WorldCat member library worldwide

Espressione del gene per le subunità ß del canale BK su aorta addominale di ratto Wistar : tesi di laurea by Anna Fiorentini( Book )

1 edition published in 2003 in Italian and held by 1 WorldCat member library worldwide

Sintesi di idrazoni, ossime e benzocarbazoli a potenziale attività analgesica e antiinfiammatoria : tesi di laurea by Maria Digiacomo( Book )

1 edition published in 2002 in Italian and held by 1 WorldCat member library worldwide

Dispense del corso di farmacologia e farmacoterapia I by Paola Nieri( Book )

1 edition published in 2002 in Italian and held by 1 WorldCat member library worldwide

L'espressione dei geni "CB1", "CB2" e "faah" nel tessuto adiposo e vas deferens di ratto : tesi di laurea by Claudia Orsucci( Book )

in Italian and held by 1 WorldCat member library worldwide

I mediatori infiammatori dell'asma : [tesi di laurea] by Andrea Pozzilli( Book )

1 edition published in 1999 in Italian and held by 1 WorldCat member library worldwide

Il trattamento farmacologico dell'obesità ; Lo stato dell'arte : tesi di laurea by Sabrina Colombino( Book )

1 edition published in 2003 in Italian and held by 1 WorldCat member library worldwide

Vaccini biotecnologici : tesi di laurea by Ilaria Michelucci( Book )

in Italian and held by 1 WorldCat member library worldwide

AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Abstract : Human cutaneous melanoma is an aggressive and chemotherapy-resistant type of cancer. AM251 is a cannabinoid type 1 (CB1) receptor antagonist/inverse agonist with off-target antitumor activity against pancreatic and colon cancer cells. The current study aimed to characterize the in-vitro antimelanoma activity of AM251. The BRAF V600E mutant melanoma cell line, A375, was used as an in-vitro model system. Characterization tools included a cell viability assay, nuclear morphology assessment, gene expression, western blot, flow cytometry with Annexin V-FITC/7-AAD double staining, cell cycle analyses, and measurements of changes in intracellular cAMP and calcium concentrations. AM251 exerted a marked cytotoxic effect against A375 human melanoma cells with potency comparable with that observed for cisplatin without significant changes in the human dermal fibroblasts viability. AM251, at a concentration that approximates the IC50, downregulated genes encoding antiapoptotic proteins (BCL2 and survivin) and increased transcription levels of proapoptotic BAX, induced alteration of Annexin V reactivity, DNA fragmentation, chromatin condensation in the cell nuclei, and G2/M phase arrest. AM251 also induced a 40% increase in the basal cAMP levels, but it did not affect intracellular calcium concentrations. The involvement of GPR55, TRPA1, and COX-2 in the AM251 mechanism of action was excluded. The combination of AM251 with celecoxib produced a synergistic antitumor activity, although the mechanism underlying this effect remains to be elucidated. This study provides the first evidence of a proapoptotic effect and G2/M cell cycle arrest of AM251 on A375 cells. This compound may be a potential prototype for the development of promising diarylpyrazole derivatives to be evaluated in human cutaneous melanoma
Synthesis and evaluation of the pharmacological activity of rigid analogues of sympathomimetic catecholamines derived from bicyclo[2.2.1]heptane( Book )

1 edition published in 1989 in English and held by 1 WorldCat member library worldwide

Espressione del gene per la subunità alfa del canale BK in aorta addominale di ratto Wistar : tesi di laurea by Carlotta Nardini( Book )

1 edition published in 2003 in Italian and held by 1 WorldCat member library worldwide

Clonazione di marcatori genici specie-specifici ottenuti con la tecnica RAPD in piante del genere echinacea : tesi di laurea by Silvia Bonaiuti( Book )

1 edition published in 2003 in Italian and held by 1 WorldCat member library worldwide

Proprietà dei recettori dopaminergici nei bastoncelli retinici dei mammiferi : tesi di laurea by Maria Castagna( Book )

1 edition published in 2000 in Italian and held by 1 WorldCat member library worldwide

Recettori delle endoteline : caratterizzazione biochimica : tesi di laurea by Andrea Bianchi( Book )

1 edition published in 1996 in Italian and held by 1 WorldCat member library worldwide

 
moreShow More Titles
fewerShow Fewer Titles
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.98 (from 0.88 for AM251 indu ... to 0.99 for Analisi di ...)

Languages