WorldCat Identities

Pappenheimer, J. R.

Overview
Works: 2 works in 3 publications in 1 language and 3 library holdings
Publication Timeline
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Most widely held works by J. R Pappenheimer
Peptidoglycans as Promoters of Slow-Wave Sleep. I. Structure of the Sleep-Promoting Factor Isolated from Human Urine( Book )

2 editions published in 1984 in English and held by 2 WorldCat member libraries worldwide

The structures of components of the sleep-promoting material purified from human urine were established by fast atom bombardment-mass spectrometry. We report here that two substances isolated from that preparation, viz. N-acetylglucosaminyl-1,6-anhydro-N-acetylmuramyl-Ala-gamma-Glu-diaminopimelyl-Ala) and that compound lacking the terminal alanine, are active as somnogens. Cerebro-intraventricular administration of 1 pmol of the glycotetrapeptide was sufficient to induce prolonged excess sleep in rabbits. Findings show that in addition to the muramyl form of peptidoglycan monomers, the anhydro muramyl form, with no reducing end, is compatible with somnogenic activity. Furthermore, the data obtained with a natural product amplify our earlier observations with smaller synthetic molecules of the importance of amidation/deamidation in the structure-activity relationships of muramyl peptides
The respiratory response to disturbances of acid-base balance; with deductions concerning the ionic composition of cerebral interstitial fluid by Vladimir Fencl( Book )

1 edition published in 1966 in English and held by 1 WorldCat member library worldwide

 
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Audience level: 0.99 (from 0.98 for The respir ... to 1.00 for Peptidogly ...)

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