WorldCat Identities

Rabinowitz, Joshua D.

Overview
Works: 13 works in 14 publications in 1 language and 18 library holdings
Genres: Academic theses 
Roles: Other, Contributor, Author
Publication Timeline
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Most widely held works by Joshua D Rabinowitz
A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolites by Wenyun Lu( )

1 edition published in 2005 in English and held by 2 WorldCat member libraries worldwide

Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate by Jurre J Kamphorst( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia by Russell A Miller( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

LC-MS and GC-MS based metabolomics platform for cancer research by Wenyun Lu( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate by Li Chen( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions by Sophia Hsin-Jung Li( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Biclustering via optimal re-ordering of data matrices in systems biology: rigorous methods and comparative studies by Peter A DiMaggio( )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

Enhancing the metabolic capacity of cyanobacteria for biological hydrogen production: Biofuel applications of Cyanothece and Arthrospira spp by Nicholas John Skizim( Book )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

In Chapter 1, we characterize hydrogen production from the nitrogen-fixing (diazotrophic) cyanobacterium Cyanothece sp. Miami BG 043511. This organism is capable of producing H2 via the bidirectional hydrogenase as well as the nitrogenase complex. We illustrate that dark, autofermentative H2 production is catalyzed by the hydrogenase, whereas photo-fermentative H2 production (photo-H2) is catalyzed by nitrogenase and is dependent upon excitation of Photosystem I. Internal carbohydrate reserves supply the reductant for both pathways; this reductant is therefore shared between the two H2 producing modes. We illustrate that by allowing increased time for autofermentation, the available reductant (generated from carbohydrate catabolism) is increased and an increased photo-H2 production rate is observed
Nutrient signal integration in Escherichia coli by Christopher Doucette( Book )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Microbes survive in a variety of nutrient environments by modulating their metabolism. Balanced growth requires that the uptake of various nutrients, the rate of intracellular catabolism and biosynthesis, and the overall growth rate are coordinated in their response to environmental fluctuations in nutrient availability, the primary substrates for biomass production. While the structure of the metabolic network is known and much biochemical data is available concerning the regulation of individual reactions, the mechanisms that integrate nutrient signal information into a coordinated regulatory plan are incompletely understood. Through a combination of experiment and mathematical modeling, this work explores the E. coli response to variations in nitrogen availability, and attempts to identify the mechanisms which make the nitrogen uptake pathway, the central carbon network, and the cellular growth rate each sensitive to this external variable. Beginning from a rich metabolomics dataset detailing the metabolic effects of a sudden increase in nitrogen, a detailed kinetic model of nitrogen assimilation is developed which allows the identification of the key regulatory interactions controlling the concentrations of glutamate and glutamine, the intracellular nitrogen carriers. The same dataset reveals a striking homeostasis in the concentrations of glycolytic intermediates despite an increase in glycolytic flux, leading to the discovery of a new feedback mechanism which renders glucose uptake sensitive to nitrogen limitation through inhibition by alpha-ketoglutarate, the carbon substrate of nitrogen assimilation. A reductionist mathematical model indicates that this mechanism is necessary and sufficient for coordination of carbon and nitrogen utilization. Oxygen uptake and oxidative citric acid cycle flux are also found to be closely tied to nitrogen availability; the rapidity of the adjustments to nitrogen perturbation argues for the primacy of small-molecule interactions and enzyme modification as modes of regulation
A metabolic strategy to reverse fibrosis? by Joshua D Rabinowitz( )

1 edition published in 2019 in English and held by 0 WorldCat member libraries worldwide

NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism by Li Chen( )

1 edition published in 2019 in English and held by 0 WorldCat member libraries worldwide

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation by Paras S Minhas( )

1 edition published in 2018 in English and held by 0 WorldCat member libraries worldwide

Autophagy maintains tumour growth through circulating arginine by Laura Poillet-Perez( )

2 editions published in 2018 in English and held by 0 WorldCat member libraries worldwide

 
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Audience Level
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Audience level: 0.95 (from 0.86 for Quantitati ... to 1.00 for Macrophage ...)

Languages
English (14)