WorldCat Identities

Ketteler, Robin

Overview
Works: 8 works in 9 publications in 1 language and 18 library holdings
Roles: Author, Other, Contributor
Publication Timeline
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Most widely held works by Robin Ketteler
Regulation der Erythropoese durch spezifische Signalübertragungskaskaden by Robin Ketteler( Book )

1 edition published in 2002 in English and held by 4 WorldCat member libraries worldwide

Towards a data-integrated cell by Noël Malod-Dognin( )

2 editions published in 2019 in English and held by 3 WorldCat member libraries worldwide

Človeštvo vse bolj kopiči molekularne podatke o celicah, pri tem pa nastaja vedno večji izziv, kako jih vključiti v enoten konceptualni in računalniški okvir, ki bi omogočil nova odkritja. V članku predlagamo nov, na podatkih temelječ koncept integrirane celice, iCell. Prav tako uvajamo računski prototip take celice, ki združuje tri vrste omičnih podatkov, ki so tkivno specifični in se nanašajo na omrežja molekulskih povezav. Predstavimo konstrukcijo iCell na osnovi tkiv štirih vrst raka in ustreznih zdravih tkiv za potrebe kontrolnih skupin in identificiramo gene, ki so pri raku najbolj povezani z drugimi geni. Mnogi od njih imajo neznane funkcije v celici in jih v nobenem posamičnem molekularnem omrežju ni mogoče opredeliti kot statistično izstopajoče pri rakavih obolenjih. Njihovo vlogo pri raku biološko potrdimo s t.i. knockdown poskusi, ki jim sledijo še testi sposobnosti preživetja celic. Dodatno podporo našim ugotovitvam najdemo tudi v Kaplan-Meierjeve krivuljah preživetja več tisoč bolnikov. Na koncu analizo razširimo na iskanje pomembnih genov, ki so skupni več rakavim obolenjem. Naša metodologija je univerzalna in omogoča integrativne primerjave različnih omičnih podatkovnih virov preko celic in tkiv
Author Correction: Towards a data-integrated cell by Noël Malod-Dognin( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA by Daniel Little( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

A pathway sensor for genome-wide screens of intracellular proteolytic cleavage by Robin Ketteler( )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

Application of Gaussia luciferase in bicistronic and non-conventional secretion reporter constructs by Christin Luft( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

Systematic Identification of Oncogenic EGFR Interaction Partners( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract: The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (TK) that--once activated upon ligand binding--leads to receptor dimerization, recruitment of protein complexes, and activation of multiple signaling cascades. The EGFR is frequently overexpressed or mutated in various cancers leading to aberrant signaling and tumor growth. Hence, identification of interaction partners that bind to mutated EGFR can help identify novel targets for drug discovery. Here, we used a systematic approach to identify novel proteins that are involved in cancerous EGFR signaling. Using a combination of high-content imaging and a mammalian membrane two-hybrid protein-protein interaction method, we identified eight novel interaction partners of EGFR, of which half strongly interacted with oncogenic, hyperactive EGFR variants. One of these, transforming acidic coiled-coil proteins (TACC) 3, stabilizes EGFR on the cell surface, which results in an increase in downstream signaling via the mitogen-activated protein kinase and AKT pathway. Depletion of TACC3 from cells using small hairpin RNA (shRNA) knockdown or small-molecule targeting reduced mitogenic signaling in non-small cell lung cancer cell lines, suggesting that targeting TACC3 has potential as a new therapeutic approach for non-small cell lung cancer. Graphical Abstract: Highlights: A combined screening approach involving an image-based green fluorescent protein-Grb2 translocation assay and a mammalian membrane two-hybrid protein-protein interaction assay identified 11 novel interactors of EGFR. Eight of those were further confirmed by co-immunoprecipitation. TACC3 was identified as a novel EGFR interactor, which specifically binds to oncogenic EGFR variants. TACC3 directly modulates EGFR stability at the cell surface and hence promotes mitogen-activated protein kinase signaling. Targeting TACC3 in non-small cell lung cancer cells partially resensitizes TK-resistant cells to TK inhibitors
 
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