WorldCat Identities

Grinholc, Mariusz

Overview
Works: 6 works in 6 publications in 2 languages and 12 library holdings
Roles: Author, Contributor
Publication Timeline
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Most widely held works by Mariusz Grinholc
Antimicrobials are a photodynamic inactivation adjuvant for the eradication of extensively drug-resistant Acinetobacter baumannii by Agata Wozniak( )

1 edition published in 2019 in English and held by 4 WorldCat member libraries worldwide

Abstract: The worldwide emergence of extensively drug resistant (XDR) Acinetobacter baumannii has reduced the number of antimicrobials that exert high bactericidal activity against this pathogen. This is the reason why many scientists are focusing on investigations concerning novel non-antibiotic strategies such as antimicrobial photodynamic inactivation (aPDI) or the use of antimicrobial blue light (aBL). Therefore, the aim of the current study was to screen for antimicrobial synergies of routinely used antibiotics and phototherapies, including both aPDI involving exogenously administered photosensitizing molecules, namely, rose bengal, and aBL, involving excitation of endogenously produced photoactive compounds. The synergy testing was performed in accordance with antimicrobial susceptibility testing (AST) standards, including various methodological approaches, i.e., antibiotic diffusion tests, checkerboard assays, CFU counting and the evaluation of postantibiotic effects (PAEs). We report that combining antimicrobials and aPDI/aBL treatment led to a new strategy that overcomes drug resistance in XDR A. baumannii, rendering this pathogen susceptible to various categories of antibiotics. Sublethal aPDI/aBL treatment in the presence of sub-MIC levels of antimicrobials effectively killed A. baumannii expressing drug resistance to studied antibiotics when treated with only antibiotic therapy. The susceptibility of XDR A. baumannii to a range of antibiotics was enhanced following sublethal aPDI/aBL. Furthermore, 3′-(p-aminophenyl) fluorescein (APF) testing indicated that significantly increased reactive oxygen species production upon combined treatment could explain the observed synergistic activity. This result represents a conclusive example of the synergistic activity between photodynamic inactivation and clinically used antimicrobials leading to effective eradication of XDR A. baumannii isolates and indicates a potent novel therapeutic approach
Antimicrobial photodynamic therapy with fulleropyrrolidine: photoinactivation mechanism of Staphylococcus aureus, in vitro and in vivo studies by Mariusz Grinholc( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Development of Staphylococcus aureus tolerance to antimicrobial photodynamic inactivation and antimicrobial blue light upon sub-lethal treatment by Aleksandra Rapacka-Zdonczyk( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

 
Audience Level
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Audience Level
1
  General Special  
Audience level: 0.00 (from 0.00 for Antimicrob ... to 0.00 for Antimicrob ...)

Alternative Names
Grinholc, Mariusz Stanisław.

Mariusz Grinholc cercetător polonez

Mariusz Grinholc chercheur polonais

Mariusz Grinholc investigador polaco

Mariusz Grinholc investigador polacu

Mariusz Grinholc investigador polonès

Mariusz Grinholc Polish researcher

Mariusz Grinholc polnischer Forscher

Mariusz Grinholc polski naukowiec

Mariusz Grinholc Pools onderzoeker

Mariusz Grinholc ricercatore polacco

Mariusz Grinholc taighdeoir Polannach

Languages