WorldCat Identities

Sanfeliu, Albert

Works: 3 works in 5 publications in 3 languages and 5 library holdings
Roles: tld, fmd, Author of screenplay
Publication Timeline
Most widely held works by Albert Sanfeliu
Corrupció, l'organisme nociu = Corrupción, organismo nocivo( Visual )

3 editions published between 2014 and 2017 in Catalan and Miscellaneous languages and held by 3 WorldCat member libraries worldwide

Apasionante relato cercano y emotivo de personas que vivieron y denunciaron la corrupción. También ofrece información útil y efectiva de la mano de reconocidos expertos en la materia, que desde una intensa argumentación dan sus claves para hacerle frente. Porque sólo desde el conocimiento de la realidad se puede influir en ella, el documental presenta, desde una perspectiva crítica y real, su origen y las grietas que permiten que la nociva corrupción llegue hasta las bases de nuestra sociedad
The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Graphical abstract: Highlights: Insulin-Like Growth Factor 1 controls brain development and plasticity. Insulin-Like Growth Factor 1 modulates different systems including neuronal transmission, metabolism and morphology. Insulin-Like Growth Factor 1 is a neuroprotective and regenerative factor in post-traumatic injury. Abstract: Insulin-Like Growth Factor 1 (IGF-1) is a phylogenetically ancient neurotrophic hormone with crucial roles to play in CNS development and maturation. Recently, IGF-1 has been shown to have potent effects on cellular neuroplasticity. Neuroplasticty refers to the adaptive changes made by the CNS in the face of changing functional demands and is crucial in processes such as learning and memory. IGF-1, signaling through its glycoprotein receptor (IGF-1R), and canonical signaling pathways such as the PI3K-Akt and Ras-Raf-MAP pathways, has potent effects on cellular neuroplasticity in the CNS. In the present review, the role of IGF-1 in brain development is reviewed, followed by a detailed discussion of the role played by IGF in cellular neuroplasticity in the CNS. Findings from models of perturbed and reparative plasticity detailing the role played by IGF-1 are discussed, followed by the electrophysiological, structural and functional evidence supporting this role. Finally, the post-lesion and post-injury roles played by IGF-1 are briefly evaluated. We discuss the putative neurobiology underlying these changes, reviewing recent evidence and highlighting areas for further research
Expression of nuclear Methyl-CpG binding protein 2 (Mecp2) is dependent on neuronal stimulation and application of Insulin-like growth factor 1( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Highlights: Mecp2 protein nuclear expression is dependent on neuronal stimulation. Increase in the cellular activity induce a decrease in Mecp2 nuclear staining. Insulin-like factor 1 (IGF1) administration induces an increase in Mecp2 expression. Abstract: Methyl-CpG binding protein 2 (MECP2) is a chromosome-binding protein that regulates the development and maintenance of brain circuits. Altered function of the protein product of MECP2 plays an important role in the etiology of many neurodevelopmental disorders. Mutations involving a loss of function are implicated in the etiology of Rett syndrome, intellectual disability, psychosis and severe encephalopathy. Conversely, MECP2 duplications have been identified in autism and intellectual disability. MECP2 action is dependent on neuronal function, as the DNA binding is modulated by activity, and it is phosphorylated in response to stimulation. Although MECP2 is considered a major risk factor for neurodevelopmental disorders, and it is a mediator of activity-dependent mechanisms, the expression levels in response to neuronal activity have never been measured. We studied the expression of Mecp2 protein and RNA in mice neuronal cultures in response to different stimulation conditions and in the presence of insulin-like growth factor1 (IGF1): a growth factor involved in brain development and plasticity. The stimulation protocols were selected according to their ability to induce different forms of synaptic plasticity: rapid depolarization, feed-forward plasticity (LTP, LTD) and feedback forms of plasticity (TTX, KCl). We find a significant reduction of Mecp2 protein nuclear expression in neurons in response to stimuli that induce a potentiation of neuronal response, suggesting that Mecp2 protein expression is modulated by neuronal activation. Application of IGF1 to the cultures induces an increase in the expression of Mecp2 transcript and nuclear Mecp2 protein in neurons. These results show that Mecp2 is responsive to neuronal stimulation and IGF1, and different stimuli have different effects on Mecp2 expression; this differential response may have downstream effects on functional mechanisms regulating brain development and plasticity
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Audience Level
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Alternative Names
Sanfeliu Rodríguez, Albert

Sanfeliu Rodríguez, Albert, 1968-