WorldCat Identities

IDIBAPS

Overview
Works: 106 works in 117 publications in 3 languages and 118 library holdings
Roles: isb
Publication Timeline
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Most widely held works by IDIBAPS
IDIBAPS : Institut d'Investigacions Biomèdiques August Pi i Sunyer by Institut d'Investigacions Biomèdiques August Pi i Sunyer( Book )

4 editions published in 2003 in 3 languages and held by 4 WorldCat member libraries worldwide

Memoria by Institut d'Investigacions Biomèdiques August Pi i Sunyer( )

in Catalan and Spanish and held by 4 WorldCat member libraries worldwide

Annual scientific report by Institut d'Investigacions Biomèdiques August Pi i Sunyer( )

in English and Spanish and held by 4 WorldCat member libraries worldwide

Model experimental d'endocarditis infecciosa( Visual )

2 editions published in 2002 in Catalan and held by 2 WorldCat member libraries worldwide

Modelo experimental de endocarditis infecciosa( Visual )

2 editions published in 2002 in Spanish and held by 2 WorldCat member libraries worldwide

Mecanismos de protección del precondicionamiento isquémico en el trasplante hepático de injertos esteatósicos by Esther Carrasco Chaumel( Book )

2 editions published between 2005 and 2006 in Spanish and held by 2 WorldCat member libraries worldwide

Implicació de factors antiangiogènics endògens en la hipertensió portal i la cirrosi hepàtica by Laura Coch Torres( Book )

1 edition published in 2014 in Catalan and held by 1 WorldCat member library worldwide

ANTECEDENTS: La síndrome de la hipertensió portal és la més greu complicació de les malalties cròniques del fetge. Estudis anteriors del nostre grup i altres grups de recerca en models experimentals d'hipertensió portal i cirrosi han demostrat l'existència d'un procés actiu d'angiogènesi en l'establiment d'aquesta malaltia. Aquests processos angiogènics estan regulats per factors proangiogènics, com VEGF, entre d'altres, i factors antiangiogènics. HIPÒTESI: L'ús de factors antiangiogènics endògens pot ser una estratègia d'inhibició de l'angiogènesi patològica en malalties com la hipertensió portal i la cirrosi més segura i efectiva que els tractaments antiangiogènics tradicionals. OBJECTIU: Determinar la implicació dels factors antiangiogènics endògens VASH1 i PEDF com a reguladors de l'angiogènesi patològica en la hipertensió portal i cirrosi hepàtica, i avaluar experimentalment noves estratègies terapèutiques pel tractament d'aquesta malaltia basades en aquests factors. METODOLOGIA: Anàlisi de l'expressió de PEDF i VASH1 en fetge i mesenteri en diferents models experimentals (CBDL, PPVL i/o CCl4) i en mostres de fetges cirròtics humans, determinant la seva implicació durant el procés de la malaltia i comparant amb l'expressió de factors proangiogènics com VEGF. A continuació, estudi dels efectes de la sobreexpressió de VASH1 i PEDF en les alteracions vasculars i hemodinàmiques de rates amb hipertensió portal i cirrosi biliar secundària, fent servir pautes de tractament profilàctiques (prevenció) i terapèutiques (intervenció). RESULTATS OBTINGUTS: Caracterització del patró d'expressió de VASH1 i PEDF en relació al factor VEGF, observant un augment d'aquests factors tan en fetge com en mesenteri de diferents models animals i en fetges cirròtics humans. Demostrant, en el cas de VASH1, una regulació per retroalimentació negativa de VASH1/VEGF, i en el cas de PEDF, suggerint un mecanisme compensatori dirigit a reduir els efectes patològics de VEGF. Per altra banda, la sobreexpressió de factors antiangiogènics endògens com PEDF i VASH1 es tradueix en efectes beneficiosos, tant esplàncnics com intrahepàtics, en animals amb hipertensió portal i cirrosi com són baixada de la pressió portal, disminució en la formació de vasos col.laterals portosistèmics, reducció de la fibrogènesi en fetge i disminució de l'angiogènesi en fetge i mesenteri. CONCLUSIONS: Els estudis realitzats en la present tesi doctoral evidencien que els factors antiangiogènics VASH1 i PEDF poden ser noves estratègies terapèutiques contra la hipertensió portal i cirrosi hepàtica gràcies a les seves propietats antiangiogèniques i antifibròtiques
Caracterització del paper de la proteïna associada a la pancreatitis en la modulació de la resposta inflamatòria by Montse Ferrés Masó( )

1 edition published in 2009 in Catalan and held by 1 WorldCat member library worldwide

Broadly neutralizing antibody responses against HIV-1 : characterization and design of new immunogens by Carolina Ferreira( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Tratamiento de la hepatitis crónica C antes y después del trasplante hepático (TH) y diagnóstico no invasivo de su recurrencia tras el TH by José Antonio Carrión Rodríguez( )

1 edition published in 2010 in Spanish and held by 1 WorldCat member library worldwide

Neuroimaging correlates of cognitive functioning in cerebrovascular disease by Marina Fernández-Andújar( Book )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

Cerebrovascular diseases (CD) are the third most common cause of death and the leading cause of disability in adults in developed countries (Carmichael, 2012; World Health Organization, 2004). Specifically, ischemic stroke and white matter lesions (WML) often result in multiple neurological, cognitive impairment and behavioral and emotional disorders (Gorelick et al., 2011; Troncoso et al., 2008). Strokes are responsible for damage in the core of the ischemic lesion but may also cause alterations in remote areas from the primary ischemic lesion. The thalamus is a key structure in the cortico-subcortical circuits (Alexander et al., 1986; Byne et al., 2009) and is involved in multiple cognitive functions (Herrero et al., 2002; Sherman, 2005) especially in functions executive, one of the most affected cognitive domains after suffering a stroke. Although it is known that the cortico- subcortical circuits are involved in cognitive functions, to date their neuroimage correlates are unknown. The overall objective of this thesis was to study the effects of a disruption in the cortico-subcortical circuits, due to a direct or remote damage, in executive functions. For the study of remote thalamic abnormalities we use the technique of diffusion tensor image (DTI) for both ischemic stroke and WML. Moreover, due to attention and cognitive inhibition are one of the most important functions of executive domain, we studied the relationship between a specific white matter (WM) tract -called Front aslant Tract (FAT)- and these functions. The study results showed that remote thalamic microstructural abnormalities secondary to a cerebrovascular lesion can occur in both ipsilateral and contralateral thalamus, in healthy subjects with WML and in patients with cerebral ischemic stroke. These thalamic abnormalities may be related to a disruption in the cortico-subcortical circuits associated with executive dysfunction. In addition, the right FAT is involved in attention and response inhibition functions in community-dwelling subjects and participants with ischemic stroke. In conclusion, the results obtained in this thesis suggest that stroke can affect the cortico-subcortical circuits through thalamic microstructural abnormalities and these could be related to cognitive dysfunction. Finally, the novel technique of DTI can play an important role in understanding the cognitive functioning in both ischemic stroke and WML
SOX11 transcription factor functional analysis in aggressive MCL by María Carmela Vegliante( Book )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin lymphomas associated with poor prognosis and frequent relapses. Recently, the neuronal transcription factor SOX11 has been identified as a very specific biomarker for MCL. SOX11 is constantly overexpressed in virtually all aggressive MCLs, and at lower levels in a subgroup of Burkitt lymphoma and acute lymphoblastic leukemia but not in other lymphoid neoplasms. SOX11 was found exclusively overexpressed in conventional MCL and totally absent in normal lymphoid cells or in MCL patients with indolent clinical course and prolonged survival. Although SOX11 function and potential target genes in lymphoid cells are poorly known, the highly specific expression in aggressive MCL suggests that it may be an important element in the development and progression of this tumor. Two publications resulted from our studies and compose this thesis. In paper I, we have studied the molecular mechanisms leading to the aberrant expression of SOX11 in aggressive MCL. MCL is one of the lymphoid neoplasms with highest number of genetic aberrations but none involving the SOX11 genomic region at chromosome 2p25. As no chromosomal changes affecting SOX11 locus were identified in MCL, we hypothesized that epigenetic events could lead to SOX11 aberrant overexpression. We performed a comprehensive SOX11 gene expression and epigenetic studies. We observed that SOX11 expression was associated with unmehtylated DNA and presence of activating histone marks (H3K9/14Ac and H3K4me3) in embryonic stem cells and some aggressive B-cell neoplasms, including MCL. Conversely, the loss of SOX11 expression in adult stem cells, normal hematopoietic cells and other lymphoid neoplasms was associated with the presence of silencing histone marks H3K9me2 and H3K27me3 with or without simultaneous DNA methylation. We concluded that the pathogenic role of SOX11 is associated with its de novo expression in some aggressive lymphoid malignancies, which is mediated by a shift from inactivating to activating histone modifications. In paper II, we have focused on uncovering putative biological functions of SOX11 in aggressive MCL. Using chromatin immunoprecipitation microarray analysis combined with gene expression profiling upon SOX11 knockdown, we identified target genes and transcriptional programs regulated by SOX11 including the block of mature B-cell differentiation, modulation of cell cycle, apoptosis, and stem cell development. PAX5 stood out as one of the major SOX11 direct target genes. SOX11 silencing downregulates PAX5, induces BLIMP1 expression, and promotes the shift from a mature B-cell into the initial plasmacytic differentiation phenotype in both MCL primary tumor cells and an in vitro model. Our results suggested that SOX11 contributes to tumor development by altering the terminal B-cell differentiation program of MCL cells. Moreover, we have demonstrated the tumorigenic ability of SOX11 in vivo, using a xenotransplant model of MCL in CB17-SCID mice. The significant reduction on tumor growth of the SOX11-silenced cells compared to the growth of control MCL cells in the xenograft experiments highlighted the implication of SOX11 expression in the aggressive behavior of this lymphoma. Overall our results demonstrated that SOX11 can act as oncogene in MCL
Mecanismos de protección en el precondicionamiento intestinal : papel del óxido nítrico y de los radicales libres del oxígeno by Anna Sola Martínez( )

1 edition published in 2000 in Spanish and held by 1 WorldCat member library worldwide

Efecto de la infección del citomegalovirus sobre receptores SLAM en macrófagos murinos by Angela María Zarama Ortiz( Book )

1 edition published in 2014 in Spanish and held by 1 WorldCat member library worldwide

Los receptores de la familia SLAM se encuentran expresados diferencialmente en la superficie de los leucocitos y juegan un papel importante en la inmunidad innata y adaptativa. En este trabajo se demuestra que el citomegalovirus (CMV) murino reduce específicamente la expresión de determinados miembros SLAM en la superficie de los macrófagos infectados. Mediante el escrutinio de un panel de mutantes de deleción del CMV murino se ha identificado m154 como el producto viral que modula la expresión del receptor SLAM CD48, el cual constituye el ligando de alta afinidad de CD244, una molécula involucrada en la regulación funcional de las células NK y T citotóxicas. Se muestra que m154 es una proteína tipo mucina, que se expresa con una cinética temprana y se localiza en la superficie de la célula infectada. La proteína viral actúa a través de un mecanismo que implica la degradación de CD48, siendo capaz de interferir con la respuesta citotóxica de las células NK desencadenada por la infección de los macrófagos por el CMV murino. Finalmente, demostramos en el modelo murino, que m154 le proporciona al virus protección in vivo frente al ataque de las células NK. Estos hallazgos contribuyen a un mejor entendimiento de la patogénesis del CMV y proveen un nuevo ejemplo de evasión de la inmunidad innata del huésped desarrollado por CMV
KATP channel blockade instructs microglia to foster brain repair and neurogenesis after stroke by Fco. Javier Ortega González( Book )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

Plasticity of dust cells in the embryonic and postnatal pancreas by Myriam Solar Abboud( )

1 edition published in 2011 in English and held by 1 WorldCat member library worldwide

Estudio de los tocotrienoles como inductores de muerte programada en las células estrelladas del páncreas by Mariana Rickmann Ashwell( )

1 edition published in 2010 in Spanish and held by 1 WorldCat member library worldwide

Cell-type specific microRNA regulation of adenovirus for selective treatment of pancreatic ductal adenocarcicoma by Xavier Bofill i de Ros( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

 
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Audience level: 0.96 (from 0.93 for Memoria / ... to 0.98 for IDIBAPS : ...)

Alternative Names
August Pi i Sunyer Institute of Biomedical Research

IDIBAPS

Institut d'Investigacions Biomèdiques August Pi i Sunyer

Instituto de Investigaciones Biomedicas August Pi i Sunyer

Instituto de Investigacións Biomédicas August Pi i Sunyer

Languages
Spanish (14)

English (10)

Catalan (7)