WorldCat Identities

Glotz, Denis

Overview
Works: 20 works in 31 publications in 2 languages and 37 library holdings
Roles: Thesis advisor, Author, Contributor, Opponent, Other
Publication Timeline
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Most widely held works by Denis Glotz
Néphrologie : conforme aux nouveaux programmes by D Glotz( Book )

5 editions published between 1990 and 1993 in French and held by 8 WorldCat member libraries worldwide

Mécanismes d'action des immunoglobulines humaines à usage intraveineux (IgIV) en xénotransplantation by Olivier Schussler( )

2 editions published in 2000 in French and held by 4 WorldCat member libraries worldwide

La carence actuelle en organes allogéniques transplantables et l'acquisition de nouvelles techniques de biologie moléculaire (transgénèse, recombinaison homologue, clonage) ont suscité un renouveau d'intérêt pour la xénotransplantion. Le porc apparaît comme le donneur privilégié d'organes chez l'homme. Cependant les organes porcins implanté chez le primate humain sont rejetés de manière hyperaigu par un mécanisme physiopathologique impliquant la fixation d'anticorps naturels préexistant sur l'endothélium du greffon (XNA), par activation du complément du receveur (voie alterne ou voie classique) et activation de la cellule endothéliale. Les immunoglobulines humaines à usage intraveineux (IVIg) ont été utilisées par notre équipe pour différer le rejet hyperaigu vasculaire dans le modèle de xénogreffe cardiaque discordant : cobaye / rat. Dans ce travail nous avons étudié in vitro la fixation des XNA IgG et IgM de rat et des IVIg sur la cellule endothéliale de cobaye (GEPC) et la modification de cette fixation par des interactions de type idiotype antiidiotype entre ces XNA et les IVIg. La diminution du titre d'XNA IgG anti GEPC sous IVIg est corrélée à la prolongation de la survie du greffon. En enregistrant en temps réel les mouvements calciques intracytoplasmiques et la libération de NO provoqués par la fixation de ces différents XNA, nous avons mis en évidence une modification par les IVIg humaines uniquement de la capacité de la GEPC à répondre à la thrombine, principale agoniste impliqué in vivo dans l'activation de type I de cette cellule. Des études ultérieures réalisées sur la cellule endothéliale allogénique HUVEC, sont venues confirmer la modification par la partie F(ab')2 des IVIg, du calcium intracytoplasmique basal et de la signalisation de récepteurs couplés à des protéines G, en interagissant avec l'activité de tyrosines kinases ou de phospholipases C associées à ces récepteurs. Le contrôle de l'activation de la cellule endothéliale par les IVIg fixées pourrait expliquer l'effet bénéfique des IVIg dans de nombreuses pathologies où le tableau clinique associe une atteinte de la paroi vasculaire
EFFETS ET MECANISMES D'ACTION DES IMMUNOGLOBULINES HUMAINES A USAGE INTRAVEINEUX (IGIV) LORS DES XENOGREFFES DISCORDANTES by DELPHINE GENEVAZ( Book )

2 editions published in 1998 in French and held by 3 WorldCat member libraries worldwide

LE FAIT QUE LA XENOTRANSPLANTATION PUISSE DEVENIR UNE SOLUTION AU DEFICIT D'ORGANES, A CONDUIT PLUSIEURS EQUIPES A ETUDIER ET TENTER D'INHIBER LES MECANISMES DU REJET INDUITS PAR CE TYPE DE TRANSPLANTATION. LE REJET HYPERAIGU QUI INTERVIENT LORS DE XENOGREFFES DISCORDANTES COBAYE-RAT OU PORC-HOMME IMPLIQUE D'UNE PART LE SYSTEME DU COMPLEMENT ET LES ANTICORPS NATURELS XENOGENIQUES ET D'AUTRE PART LA CELLULE ENDOTHELIALE ET LE SYSTEME DE LA COAGULATION. DE NOS JOURS, LE PORC APPARAIT COMME LE DONNEUR PREFERENTIEL D'ORGANES, MAIS LES ETUDES IN VIVO SONT SIMPLIFIEES PAR L'UTILISATION DE MODELES ANIMAUX PLUS PETITS COMME LE MODELE COBAYE-RAT. LES NOMBREUX EFFETS DES IMMUNOGLOBULINES HUMAINES A USAGE INTRAVEINEUX (IGIV) SUR LE SYSTEME IMMUNITAIRE ET LEUR ACTION BENEFIQUE EN ALLOTRANSPLANTATION, NOUS ONT INCITE A LES ADMINISTRER AU RECEVEUR, EN MODE PREOPERATOIRE IMMEDIAT, DANS UNE XENOGREFFE DISCORDANTE CARDIAQUE HETEROTOPIQUE COBAYE-RAT. NOUS AVONS MONTRE QUE LA PERFUSION D'IGIV ENTIERES AINSI QUE DE LEURS FRAGMENTS F(AB')#2 ET FC RETARDAIT LE REJET HYPERAIGU. LA PROLONGATION DE LA SURVIE ETAIT LIEE A UNE DIMINUTION DE L'ACTIVITE HEMOLYTIQUE DU COMPLEMENT ET PLUS PARTICULIEREMENT A UNE ACTIVATION DE CE DERNIER INDUITE PAR LES FRAGMENTS F(AB')#2. NOUS AVONS EGALEMENT DEMONTRE QUE LA PARTIE F(AB')#2 DES IGIV INHIBAIT LA FIXATION DES ANTICORPS XENOGENIQUES DE RAT D'ISOTYPE IGG, A LA CELLULE ENDOTHELIALE DE COBAYE. CEPENDANT, L'INHIBITION, OBTENUE PAR LES IGIV, DE LA CYTOTOXICITE DU PLASMA DE RAT ENVERS LA CELLULE ENDOTHELIALE EST PRINCIPALEMENT DUE A L'ACTION ANTI-COMPLEMENTAIRE DE LA PARTIE F(AB')#2 DES IGIV. ENFIN, UNE APPROCHE MOLECULAIRE DU SUJET, NOUS INCITE A PENSER QUE LES IGIV INHIBENT L'ACTIVATION DE LA CELLULE ENDOTHELIALE INDUITE PAR LA FIXATION DES ANTICORPS XENOGENIQUES. AINSI, L'UTILISATION DES IGIV EN XENOTRANSPLANTATION REVELE LEUR CAPACITE A MODULER CERTAINS PROTAGONISTES DU REJET. LEUR UTILISATION, ASSOCIEE A D'AUTRES MODULATEURS, POURRAIT S'AVERER BENEFIQUE POUR LA SURVIE DE LA XENOGREFFE
Rôle des anticorps anti-HLA en transplantation rénale by Carmen Mocanu Lefaucheur( Book )

2 editions published in 2013 in French and held by 3 WorldCat member libraries worldwide

The alloimmune response induced by transplantation from a donor who differs genetically from the kidney recipient has always been the major obstacle to graft success. The present work aimed to improve characterization of kidney-allograft rejection phenotypes and identify how each one is associated with anti-HLA antibodies. We also sought to determine whether characteristics of these antibodies i.e., their levels or complement-binding ability, might play a role in kidney allograft failure. We used a population-based approach in precisely phenotyped cohorts of kidney recipients. The design of our study, which is based on the concomitant evaluation of immunologic and histologic data, permits a precise connection of circulating anti-HLA antibodies with a phenotype of-graft injury. We identified four distinct patterns of kidney allograft rejection: T cell (9%) and antibody-mediated vascular rejection (21%), not included in international classifications and T cell (46%) and antibody-mediated rejection without vasculitis (24%). Risk of graft loss was 9.07 times (95CI 3.6-19.7) higher in antibody-mediated vascular rejection than in T-cell mediated rejections.Patients with post-transplant complement-binding DSA had more severe graft injury phenotype with higher inflammation and increased deposition of complement fraction C4d. They have the poorest graft survival with 3.7 fold increased risk of graft loss (95CI 1.9-7.2).This work addresses the unmet need of the deleterious impact of anti-HLA antibodies and improves risk stratification in kidney transplantation. Recognition of distinct phenotypes could lead to the development of new treatment strategies
RESEAU IDIOTYPIQUE ET AUTOANTICORPS EN PERIODE NEONATALE by Denis Glotz( Book )

2 editions published in 1990 in French and held by 2 WorldCat member libraries worldwide

LE REPERTOIRE NEONATAL DES CELLULES B DE SOUIRS BALB/C EST ETUDIE PAR HYBRIDATION SOMATIQUE DE CELLULES SPLENIQUES PRELEVEES A LA 24EME HEURE DE VIE. LA PLUPART DES HYBRIDOMES OBTENUS POSSEDENT UNE ACTIVITE AUTOANTICORPS, SONT POLYREACTIFS, APPARTIENNENT A LA SOUS-CLASSE IGG2B ET ONT UNE ORIGINE GENETIQUE PARTICULIERE MARQUEE PAR L'UTILISATION PREFERENTIELLE DE LA FAMILLE DE GENES V#H7183. LA COMPARAISON DE L'UN DE CES AUTOANTICORPS NEONATAUX, DIRIGE CONTRE LA THYROGLOBULINE, A UN AUTO-ANTICORPS DE MEME SPECIFICITE OBTENU PAR IMMUNISATION D'UN ANIMAL ADULTE MONTRE QUE CES 2 ANTICORPS FIXENT LE MEME SITE DE LA THYROGLOBULINE AVEC UNE AFFINITE COMPARABLE, EXPRIMENT LE MEME IDIOTYPE REGULATEUR A LA FOIS SUR LEURS CHAINES LOURDES ET LEGERES, SONT DERIVES DE LA MEME FAMILLE DE GENES, ET ONT ENFIN LA MEME SEQUENCE NUCLEOTIDIQUE, AFFIRMANT AINSI LEUR TOTALE IDENTITE ET LEUR TRANSCRIPTION DIRECTE DU GENOME. SONT EGALEMENT DECRITS UN ANTICORPS A ACTIVITE FACTEUR RHUMATOIDE AINSI QU'UN ANTICORPS DIRIGE CONTRE UN DETERMINANT DE SURFACE DES CELLULES T. L'ENSEMBLE DE CES RESULTATS, EN ACCORD AVEC LA LITTERATURE, PERMET D'ENVISAGER UN SCHEMA DE DEVELOPPEMENT DU SYSTEME IMMUNITAIRE BASE SUR L'EXPRESSION PREMIERE D'AUTOANTICORPS DERIVES SANS MUTATIONS DU GENOME, EN PARTIE CONTROLES PAR DES INTERACTIONS IDIOTYPIQUES, DONT L'EXPANSION SOMATIQUE ULTERIEURE CONDUIT AU REPERTOIRE ADULTE
MALADIES A CYTOMEGALOVIRUS CHEZ LES TRANSPLANTES RENAUX TRAITES PAR TACROLIMUS OU MYCOPHENOLATE MOFETIL by Béatrice Pegaz-Fiornet( Book )

1 edition published in 2001 in French and held by 2 WorldCat member libraries worldwide

DESENSIBILISATION DES SUJETS IMMUNISES DANS LE SYSTEME HLA EN ATTENTE DE TRANSPLANTATION RENALE by Jean-Philippe Haymann( Book )

1 edition published in 1995 in French and held by 2 WorldCat member libraries worldwide

Activation de la cellule endothéliale en conditions xénogéniques et modulation par les immunoglobulines humaines intraveineuses by Christelle Ratignier( Book )

2 editions published in 2003 in French and held by 2 WorldCat member libraries worldwide

Acute respiratory failure in kidney transplant recipients: a multicenter study by Emmanuel Canet( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

Etude du réseau idiotypique dans le modèle de la glomérulonéphrite induite par le bichlorure de mercure chez le rat Brown-Norway by Denis Glotz( Book )

2 editions published in 1984 in French and held by 2 WorldCat member libraries worldwide

Effect of sirolimus on malignancy and survival after kidney transplantation : systematic review and meta-analysis of individual patient data by Greg A Knoll( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

Characterization of T follicular helper cells and mechanisms of anti-HLA donor specific antibody generation after transplantation by Kevin Louis( )

1 edition published in 2020 in English and held by 1 WorldCat member library worldwide

The immune conflict induced by the development of donor-specific anti-HLA antibodies (DSA) represents the main limitation to prolonged survival of organ transplants. Improvement in transplant outcomes therefore requires a better understanding of the mechanisms underlying the development of DSA and antibody-mediated rejection (ABMR), which is the leading cause of allograft loss. While previous studies investigating the mechanisms of ABMR have focused on characterizing the deleterious role of DSA, the alloreactive cellular component has been less studied. The hypothesis developed in this work is that the T cell component and its interaction with B cells play a crucial role in the pathophysiology of ABMR. The concomitant and multidimensional analysis of blood T and B cells identified highly coordinated circulating T follicular helper (cTFH) and activated B cell responses at phenotypic, transcriptional and functional levels in patients undergoing ABMR. This analysis demonstrates the acquisition of a proliferative state, the overexpression of costimulatory molecules and the increased production of IL-21 by cTFH cells. In addition, IL-21 induces the accumulation of activated memory B cells overexpressing the transcription factor T-bet, which represented plasma cell precursors that produced DSA. The concomitant accumulation in blood of activated cTFH and memory B cells reflected more severe forms of ABMR characterized by: presence of inflammatory DSA of IgG3 isotype, more severe vascular lesions of the kidney allograft and poorer clinical outcomes. Thus, this work provides new insights into the cellular and molecular mechanisms which coordinate TFH and B cell immune responses, and which underlie the generation of DSA and the ABMR process. This work therefore provides a rationale for immune monitoring and therapeutic targeting of TFH-B interaction during ABMR
The significance of chronic inflammation and HLA-DQ alloantibodies in endothelhial immunoregulation during antibody-mediated rejection by Amy Cross( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

In solid organ transplantation, antibody-mediated rejection is currently the major cause of allograft failure. Antibody-mediated rejection is a disease of the allograft vasculature, characterised by inflammation and circulating donor-specific antibodies. Recent studies have exposed the particularly high prevalence of antibodies targeting HLA-DQ amongst de novo donor-specific antibodies produced post-transplantation. This thesis explores the significance of endothelial HLA-DQ expression in the pathogenesis of antibody-mediated rejection. HLA-DQ expression in in vitro microvascular endothelial cell cultures required sustained exposure to inflammatory cytokines. Such inflammation modified endothelial immunogenicity and subsequent synapses with alloreactive CD4+ T lymphocytes. As a consequence, sustained inflammation compromised the capacity of endothelial cells to expand anti-inflammatory regulatory T cells. Moreover, the binding of HLA-DQ alloantibodies to the endothelial cells synergised with inflammation to further diminish regulatory T cell expansion. This reduction in anti-inflammatory cells may impair allograft tolerance, promote proinflammatory responses and exacerbate rejection
Annual congress of the French Transplantation Society( Book )

1 edition published in 2000 in English and held by 1 WorldCat member library worldwide

Second international joint meeting of the Francophone Transplantation Societies by Francophone Transplantation Societies( Book )

2 editions published in 2000 in English and held by 1 WorldCat member library worldwide

INDUCTION DE TOLERANCE D'ALLOGREFFE CARDIAQUE CHEZ DES SOURIS PORTEUSES D'UN GENE-SUICIDE EXPRIME PAR LES LYMPHOCYTES T MATURES by NATHALIE RAYNAL RASCHILAS( Book )

1 edition published in 1999 in French and held by 1 WorldCat member library worldwide

Proceedings of the Fifth International Symposium on Intestinal Transplantation, 30 July-2 August 1997, Cambridge, UK( Book )

1 edition published in 1998 in English and held by 0 WorldCat member libraries worldwide

Proceedings of the Vth Congress of the Portuguese Transplantation Society, November 4-6, 1999, Oporto, Portugal by Sociedade Portuguesa de Transplantação( Book )

1 edition published in 2000 in English and held by 0 WorldCat member libraries worldwide

Proceedings of the 35th annual congress of the Japan Society for Transplantation by Nihon Ishoku Gakkai( Book )

1 edition published in 2000 in English and held by 0 WorldCat member libraries worldwide

Annual congress of the French Transplantation Society, December 10, 11, 1999, Paris, France( Book )

1 edition published in 2000 in English and held by 0 WorldCat member libraries worldwide

 
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Alternative Names
Denis Glotz onderzoeker

Languages
French (20)

English (11)