WorldCat Identities

Fukui, Nobuyuki

Overview
Works: 4 works in 5 publications in 2 languages and 7 library holdings
Roles: Author
Classifications: HN723,
Publication Timeline
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Most widely held works by Nobuyuki Fukui
Higashiajia no keizai seichō no jizoku kanōsei ni tsuite( Book )

2 editions published in 2016 in Japanese and held by 3 WorldCat member libraries worldwide

The Japanese leisure traveler abroad : an analysis of guest comment cards in a major resort hotel by Nobuyuki Fukui( )

1 edition published in 1999 in English and held by 2 WorldCat member libraries worldwide

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract Background Glioblastomas have been shown to rely on glycolysis as an energy source. However, recent evidence suggests that at least a subset of glioma cells with stem cell–like properties can thrive on oxidative phosphorylation. It remains unclear whether both metabolic phenotypes support tumor propagation, if they are independent, and how stable they are. The present study investigated these questions with the use of isogenic murine glioma stem cells (GSCs). Methods GSCs were established from tumors formed by Ink4a/Arf–null, H-Ras-expressing glioma-initiating cells that differed in extracellular acidification potential. Metabolic characteristics of GSCs were determined by measurement of glucose, oxygen, and glutamine uptake, ATP content, and lactate production. Effects of metabolic inhibitors and changes in oxygen or nutrient availability on lactate production and tumorsphere growth were also determined. Results GSCs were found either to consume more glucose and produce more lactate or to consume more oxygen and maintain a higher ATP content depending on the metabolic characteristics of the tumor cells of origin. The latter, mitochondrial-type GSCs increased lactate production after treatment with the oxidative phosphorylation inhibitor oligomycin or phenformin. Exposure to hypoxia also increased lactate production and expression of glycolysis-related enzymes and metabolites in mitochondrial-type GSCs in a reversible manner. Conclusions Both glycolytic and mitochondrial-type energy production can sustain tumor propagation by isogenic GSCs. Whereas both phenotypes can be independent and stable, cells that rely on oxidative phosphorylation can also switch to a more glycolytic phenotype in response to metabolic stress, suggesting that plasticity is a further characteristic of GSC metabolism
Kinsei kindai Nihon shakai no tenkai to shakai shokagaku no genzai : Morita Takeshi Kyōju taikan kinen ronbunshū( Book )

1 edition published in 2007 in Japanese and held by 1 WorldCat member library worldwide

 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.84 (from 0.68 for The Japane ... to 0.93 for Higashiaji ...)

Alternative Names
Fukui, Nobuyuki

フクイ, ノブユキ

Languages