WorldCat Identities

Tessier, Agnès

Overview
Works: 4 works in 4 publications in 1 language and 6 library holdings
Roles: Author
Publication Timeline
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Most widely held works by Agnès Tessier
Procollagen C-proteinase enhancers in skin wound healing expression, functions and therapeutic potential by Agnès Tessier( Book )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases by Monique Lacroix( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Procollagen C-Proteinase Enhancers in skin wound healing : expression, functions and therapeutic potential by Agnès Tessier( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

The imbalance between collagen assembly and degradation during skin wound healing is a major factor contributing to wound healing pathologies. Fibrillar collagen precursors are synthesized by fibroblasts and processed in the extracellular space by specific metalloproteases (e.g. BMP-1/Tolloid-like Proteinases, or BTPs) to form collagen fibrils. These proteolytic maturations can be efficiently stimulated by two glycoproteins, Procollagen C-Proteinase Enhancers (PCPE-1 and -2). The main goal of our study was to analyze the possible redundant and specific roles of the two PCPE proteins during wound healing.Interestingly, both BTPs and PCPE-1 were found to be expressed in the dermis and to be significantly increased during the first week after injury. Surprisingly, PCPE-1 is mainly expressed by dermal fibroblasts, whereas PCPE-2 is lowly expressed in fibroblasts and more abundant in basal keratinocytes. Moreover, PCPE-2 appears to be expressed by myeloid cells suggesting that PCPE-2 might rather play a role during the inflammatory phase of wound healing. In addition, our results indicate that recombinant PCPE 2 does not efficiently enhance their proteolytic maturation of fibrillar procollagens and can even inhibit the action of BMP-1 on other non-collagenous substrates, suggesting a differential and unexpected role of PCPE-2. Finally, the in vivo role of PCPE-2 was investigated using a Pcolce2 knockout model; skin morphology and wound healing were not affected by PCPE-2 loss, indicating that PCPE-1 is the main enhancer involved in collagen deposition during wound healing. Thus, this work suggests that PCPE-1 and -2 play distinct roles in the skin and during wound healing
Interaction of complement defence collagens C1q and MBL with BMP-1/tolloid-like proteinases( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

 
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