WorldCat Identities

Linköpings universitet Institutionen för klinisk och experimentell medicin

Overview
Works: 1,628 works in 1,670 publications in 2 languages and 1,671 library holdings
Genres: Academic theses 
Roles: Publisher, pub
Classifications: RC280.S5, 616.994061
Publication Timeline
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Most widely held works by Linköpings universitet
Clinical-epidemiological studies on cutaneous malignant melanoma : a register approach by Johan Lyth( Book )

2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide

Genetic variations in the NLRP3 inflammasome : susceptibility factor for chronic inflammation by Deepti Verma( Book )

2 editions published in 2011 in English and held by 2 WorldCat member libraries worldwide

Understanding the role of EGFR in the treatment of head and neck squamous cell carcinoma by Adam Jedliński( Book )

2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide

Online Sexual Behaviours Among Swedish Youth : Characteristics, Associations and Consequences by Linda S Jonsson( Book )

2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide

P73 in colorectal cancer by Daniella Pfeifer( Book )

2 editions published in 2009 in English and held by 2 WorldCat member libraries worldwide

Irritable Bowel Syndrome : Studies of central pathophysiological mechanisms and effects of treatment by Mats Lowén( Book )

2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide

Astrocyte elevated gene-1 in relation to colorectal cancer development and radiotherapy response by Sebastian Gnosa( Book )

2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide

Cancer and cancer stem cell targeting agents a focus on salinomycin and apoptin by Jaganmohan Reddy Jangamreddy( Book )

2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide

Stress in childhood and the risk of type 1 diabetes by Maria Nygren( Book )

2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide

Oxidative stress-related damage of retinal pigment epithelial cells : possible protective properties of autophagocytosed iron-binding proteins by Markus Karlsson( Book )

2 editions published in 2014 in English and held by 2 WorldCat member libraries worldwide

Infection control of Staphylococcus aureus : spa typing to elucidate transmission by Sara Mernelius( Book )

2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide

Hörselscreening av en population med utvecklingsstörning : utvärdering av psykoakustisk testmetod och av OAE-registrering som komplementär metod by Eva Andersson( Book )

2 editions published in 2013 in Swedish and held by 2 WorldCat member libraries worldwide

Body composition of parents and their infants methodological, anthropometric, metabolic and genetic studies by Pontus Henriksson( Book )

2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide

Short peptide analogs as alternatives to collagen in pro-regenerative corneal implants by Jaganmohan Jangamreddy( )

2 editions published in 2018 in English and held by 2 WorldCat member libraries worldwide

Short collagen-like peptides (CLPs) are being proposed as alternatives to full-length collagen for use in tissue engineering, on their own as soft hydrogels, or conjugated to synthetic polymer for mechanical strength. However, despite intended clinical use, little is known about their safety and efficacy, mechanism of action or degree of similarity to the full-length counterparts they mimic. Here, we show the functional equivalence of a CLP conjugated to polyethylene glycol (CLP-PEG) to full-length recombinant human collagen in vitro and in promoting stable regeneration of corneal tissue and nerves in a pre- clinicalmini-pig model. We also show that these peptide analogs exerted their pro-regeneration effects through stimulating extracellular vesicle production by host cells. Our results support future use of CLP-PEG implants for corneal regeneration, suggesting the feasibility of these or similar peptide analogs in clinical application in the eye and other tissues. Statement of significance Although biomaterials comprising full-length recombinant human collagen and extracted animal collagen have been evaluated and used clinically, these macromolecules provide only a limited number of functional groups amenable to chemical modification or crosslinking and are demanding to process. Synthetic, customizable analogs that are functionally equivalent, and can be readily scaled-up are therefore very desirable for pre-clinical to clinical translation. Here, we demonstrate, using cornea regeneration as our test bed, that collagen-like-peptides conjugated to multifunctional polyethylene glycol (CLP-PEG) when grafted into mini-pigs as corneal implants were functionally equivalent to recombinant human collagen-based implants that were successfully tested in patients. We also show for the first time that these materials affected regeneration through stimulation of extracellular vesicle production by endogenous host cells that have migrated into the CLP-PEG scaffolds. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd
Lysosomal network proteins as biomarkers and therapeutic targets in neurodegenerative disease by Andrea Boman( Book )

2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide

Toward an integrated approach in research on interpersonal violence : Conceptual and methodological challenges by Johanna Simmons( Book )

2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide

Applications of human skin in vitro by Susanna Lönnqvist( Book )

2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide

Immunoglobulin A anti-phospholipid antibodies in Swedish cases of systemic lupus erythematosus: associations with disease phenotypes, vascular events and damage accrual by Martina Frodlund( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Immunoglobulin (Ig) G- and IgM-class anti-cardiolipin antibodies (aCL) and lupus anti-coagulant (LA) are included in the 1997 update of the American College of Rheumatology (ACR-97) systemic lupus erythematosus (SLE) criteria. Despite limited evidence, IgA-aCL and IgA anti-(2)-glycoprotein-I (anti-(2)GPI) were included in the 2012 Systemic Lupus International Collaborating Clinics criteria. The present study aimed to evaluate IgG-/IgA-/IgM-aCL and anti-(2)GPI occurrence in relation to disease phenotype, smoking habits, pharmacotherapy, anti-phospholipid syndrome (APS) and organ damage among 526 Swedish SLE patients meeting ACR-97. Patients with rheumatoid arthritis (n=100), primary Sjogrens syndrome (n=50) and blood donors (n=507) served as controls. Anti-phospholipid antibodies (aPL) were analysed by fluoroenzyme-immunoassays detecting aCL/anti-(2)GPI. Seventy-six (14%) SLE cases fulfilled the Sydney APS-criteria, and 1 aCL/anti-(2)GPI isotype (IgG/IgA/IgM) occurred in 138 SLE patients (26%). Forty-five (9%) of the SLE cases had IgA-aCL, 20 of whom (4%) lacked IgG-/IgM-aCL. Seventy-four (14%) tested positive for IgA anti-(2)GPI, 34 (6%) being seronegative regarding IgG/IgM anti-(2)GPI. Six (1%) had APS manifestations but were seropositive regarding IgA-aCL and/or IgA anti-(2)GPI in the absence of IgG/IgM-aPL and LA. Positive LA and IgG-aPL tests were associated with most APS-related events and organ damage. Exclusive IgA anti-(2)GPI occurrence associated inversely with Caucasian ethnicity [odds ratio (OR)=021, 95% confidence interval (CI)=006-072) and photosensitivity (OR=019, 95% CI=005-072). Nephritis, smoking, LA-positivity and statin/corticosteroid-medication associated strongly with organ damage, whereas hydroxychloroquine-medication was protective. In conclusion, IgA-aPL is not rare in SLE (16%) and IgA-aPL analysis may have additional value among SLE cases with suspected APS testing negative for other isotypes of aPL and LA
Response to mechanical loading in healing tendons by Pernilla Eliasson( Book )

2 editions published in 2011 in English and held by 2 WorldCat member libraries worldwide

Ruptured tendons heal faster if they are exposed to mechanical loading. Loading creates deformation of the extracellular matrix and cells, which give rise to intracellular signalling, increased gene expression and protein synthesis. The effects of loading have been extensively studied in vitro, and in intact tendons in vivo. However, the response to loading in healing tendons is less known. The general aim of this thesis was to understand more about the response to mechanical loading during tendon healing. The specific aims were to find out how short daily loading episodes could influence tendon healing, and to understand more about genes involved in tendon healing. The studies were performed using rat models. Unloading of healing tendons resulted in a weaker callus tissue. This could be reversed to some extent by short daily loading episodes. Loading induced more matrix production, making the tendons thicker and stronger, but there was no improvement in the material properties of the matrix. Lengthening is one potential adversity with early loading, during tendon healing in patients. This was also seen with continuous loading in the rat models. However, short loading episodes did not result in any lengthening, not even when loading was applied during the inflammatory phase of healing. It also appeared as loading once daily was enough to make healing tendons stronger, while loading twice daily with 8 hours interval did not give any additional effect. The strongest gene expression response to one loading episode was seen after 3 hours. The gene expression changes persisted 12 hours after the loading episode but had disappeared by 24 hours. Loading appeared to regulate genes involved in inflammation, wound healing and coagulation, angiogenesis, and production of reactive oxygen species. Inflammation-associated genes were regulated both by continuous loading and by one short loading episode. Inflammation is an important part of the healing response, but too much can be harmful. Loading might therefore have a role in fine-tuning the inflammatory response during healing. In conclusion, these studies show that short daily loading episodes during early tendon healing could potentially be beneficial for rehabilitation. Loading might have a role in regulating the inflammatory response during healing
 
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Alternative Names
IKE

Linköping University. Department of Clinical and Experimental Medicine

Linköping University. Faculty of Health Sciences. Department of Clinical and Experimental Medicine

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