WorldCat Identities

Colobert, Françoise

Overview
Works: 50 works in 65 publications in 3 languages and 325 library holdings
Roles: Editor, Author, Thesis advisor, Contributor, Other, Opponent, 958
Publication Timeline
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Most widely held works by Françoise Colobert
C-H activation for asymmetric synthesis by Françoise Colobert( )

8 editions published in 2019 in English and held by 253 WorldCat member libraries worldwide

Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry
CH-activation for asymmetric synthesis( )

3 editions published in 2019 in English and held by 4 WorldCat member libraries worldwide

Diastereoselective Substrate-Controlled Transition-Metal-Catalyzed C-H Activation: An Old Solution to a Modern Synthetic Challenge( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Synthesis of an Advanced Fragment of (+)-Trienomycinol( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Etudes de couplages de Suzuki : catalyse par transfert de phase, couplage sp-sp2 et catalyse asymétrique du couplage biarylique by Anne-Sophie Castanet( Book )

2 editions published in 2001 in French and held by 2 WorldCat member libraries worldwide

Conception et synthèse de nouveaux agonistes de récepteurs métabotropiques du glutamate by Bruno Commare( )

1 edition published in 2014 in French and held by 2 WorldCat member libraries worldwide

Le glutamate est le principal neurotransmetteur excitateur du système nerveux central. Il est responsable de la majorité des transmissions synaptiques. En revanche, cet acide aminé naturel est aussi impliqué dans de nombreuses neuropathologies notamment en cas de surconcentration au niveau des synapses. Les récepteurs métabotropiques du glutamate, capables de moduler la transmission synaptique, constituent des cibles thérapeutiques prometteuses. Ces récepteurs sont divisés en trois groupes et notre laboratoire s'est focalisé sur ceux du groupe III et particulièrement le sous-type 4 qui présente des caractéristiques intéressantes dans le traitement symptomatique de la douleur et de la maladie de Parkinson. Le manque d'outils pharmacologiques de ce récepteur nous a poussé à synthétiser de nouveaux agonistes orthostériques à partir du composé référence, le LSP4-2022. Cette molécule est issue de nombreuses optimisations chimiques du (S)-PCEP provenant lui d'un screening virtuel. Durant ces trois années de doctorat, nous avons pu peaufiner la relation structure-activité autour du LSP4-2022 en synthétisant des nouveaux analogues fluorés et hétérocycliques. En parallèle, une seconde étude nous a permis d'attribuer la configuration des deux diastéréomères constituants tous les composés testés à ce jour
A Short and Easy Route to Conjugated all-E-Trienes and Tetraenes. Application to the Synthesis of Navenone B and Lignarenone B( )

1 edition published in 2000 in English and held by 2 WorldCat member libraries worldwide

Vers la synthèse totale de la Thapsigargine inhibiteur de l'enzyme SERCA by Aurélien Tap( )

1 edition published in 2013 in French and held by 2 WorldCat member libraries worldwide

Thapsigargin (Tg) is a highly oxygenated sesquiterpene lactone belonging to the guaianolide family, isolated from the Mediterranean plant species Thapsia (Apiaceae). Its interest towards treatment of prostate cancer is based on the potency of this compound as an inhibitor of the endo/sarcoplasmic calcium ATPase (SERCA) inducing an increase in cytosolic calcium concentration and leading to apoptotic cell death. A straightforward approach to a highly functionalized 8-desoxy-bicyclo[5.3.0]decadienone model close to the Tg framework has been achieved through a key Rh(I) allenic Pauson-Khand reaction (APKR). The synthetic route developed therein is robust and the yields and selectivities are high. This approach was used in the synthesis of the natural compound. Starting from the same chiral epoxide, the bottom portion of the Tg (lactone core) is first built, then C6 and C8 carbons are functionalized respectively by asymmetric reduction and enantioselective propargylation. This first way allowed to synthesize a seventeen steps-enantiopure product with C6, C7, C8 chiral centers and the lactone core. A second way is performed to set up faster the bottom part of the molecule included C6, C7, C8 and C11 asymmetric centers through a dihydroxylation step. This second approach allowed to synthesize a ten steps-racemic product with C6, C7, C8, C11 chiral centers and the lactone core. Meanwhile, a methodological study was conducted on the intramolecular allenol-yne Pauson-Khand reaction. Thirteen bicyclic compounds were synthesized in acetal and NTs series
New methodologies in organometallic chemistry : application to the synthesis of mandelate derivatives, propargylic alcohols and P-chirogenic phosphinamides by Irène Notar Francesco( Book )

2 editions published in 2010 in English and held by 2 WorldCat member libraries worldwide

Over the last decades, organometallic chemistry and catalysis contributed to the progress of modern organic chemistry, affording new synthetic methods used not only for the synthesis in laboratory, but also in industry. The presented work deals with three different organometallic reactions leading to key molecular motifs: mandelic esters, propargylic alcohols and phosphinoyl amides. In the first part we have thus presented the cross coupling reaction between aromatic boronic acids and ethyl glyoxylate as a catalytic approach to alpha-hydroxy esters. We also discussed the results obtained with enantio- and diastereoselective strategies.The second part treats the addition of lithium alkynylborates, as a truly original and chemoselective approach toward the synthesis of highly functionalized propargyl alcohols. In the last part of the manuscript we have introduced the synthesis of new P-chirogenic or chiral for the inducer derived from TADDOL directly linked to the P atom, N-phosphinoyl imines. The evaluation of the diastereoselectivity derived from the chiral inducer close to the C, N double bond have been done by the 1,2 addition of organometallic reagents
Sintesis asimétrica de heterociclos polisustituidos y applicacion a la sintesis de productos naturales by Yasmin Brinkmann( Book )

2 editions published in 2005 in Spanish and held by 2 WorldCat member libraries worldwide

Convergent Synthesis of the C18-C30 Fragment of Amphidinol 3( )

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

Synthesis of new Triazolopyridine and Triazoloquinoline based ligands and application as fluorescence sensors by Rafael Ballesteros Garrido( Book )

2 editions published in 2009 in English and held by 2 WorldCat member libraries worldwide

Les travaux présents dans ce manuscrit concernent la chimie des triazolopyridines et des triazoloquinoléines. Dans une première partie nous avons préparé les premières triazolopyridines chirales ainsi que de pyridines 2,6-disubstituées. Nous avons appliqué la méthode de la sulfoxydation catalytique vers de substrats hétéro aromatiques. La chimie de la triazoloquinoléine a été révisée pour nous donner un nouvel accès à des quinoléines 2,8-disubstituées. Nous avons étudié l'isomérisation du système triazoloquinoléine-pyridine et nous l'avons employé pour obtenir des composés très fluorescents capables de Les études réalisées on aussi permit d'évaluer les propriétés électroniques des phosphines grâce à l'isomérisation de la triazolopyridine-pyridine. En préparant une nouvelle famille de phosphines avec des triazolopyridines, nous avons pu aussi observer les effets rotationnels associés à la position du doublet du phosphore par spectroscopie de 13C-RMN. Finalement, nous avons synthétisé grâce à l'isomérisation de triazolopyridines une grande famille de ligands tridentés fluorescents qui ont été évalués comme capteurs. Certains de ces composés se sont montrés d'excellents capteurs de zinc, cuivre ou des anions et acides aminés. Pour finir, nous avons été capables de reconnaitre la chiralité de l'acide glutamique à l'aide d'un complexe avec une de nos structures, un atome de zinc et une molécule d'histidine come inducteur de chiralité
Short and Efficient Synthesis of Enantiomerically Pure 4-Substituted (1E,3E)-1[(R)-p-Tolylsulfinyl]-1,3-butadienes( )

1 edition published in 2002 in English and held by 2 WorldCat member libraries worldwide

Stereoselective Synthesis of the C(53)-C(67) Polyene Fragment of Amphidinol 3( )

1 edition published in 2007 in English and held by 2 WorldCat member libraries worldwide

A Concise and Efficient Stereoselective Synthesis of the C1-C11 Fragment of Macrolactin A( )

1 edition published in 2006 in English and held by 2 WorldCat member libraries worldwide

Nuevas aplicaciones de los derivados quirales de azufre : organocatalisis, sintesis enantioselectiva de calciomimeticos y acoplamiento de Suzuki-Miyaura by Victoria Esther Valdivia Giménez( )

2 editions published in 2010 in Spanish and held by 2 WorldCat member libraries worldwide

The design of stereoselective processes that allow access to chiral compounds with high optical purity is today one of the areas of greatest importance in organic synthesis. The main objective of this PhD was the development of highly modular new methodologies for the preparation of compounds of biological or synthetic interest using chiral sulfur derivatives.1 One of the most notable result is the development of a general method for enantiodivergent synthesis of diastereomerically pure sulfinates and their subsequent use as chiral sulfinylation agents : the method of Diacetone-D-glucose (DAG) The DAG has been exploited for: -Preparation of differents sulfoxides (1),2 and bis-sulfoxides with C2-symmetry (2, 3),3 which are excellent Lewis base in an organocatalytic process for preparing chiral allylamines. -The enantioselective synthesis of NPS-R-568 (a chiral [alpha]-methylbenzylamine with calciomimetic activity) and its trifluoromethyl analogue using the isopropylsulfinamide 4 as inducer of chirality.4 -The development of an effective methodology for the synthesis of differents biarylsulfoxides (5)5 by asymmetric Suzuki-Miyaura cross-coupling. The modularity of the approach is demonstrated by the preparation of a variety of enantiopure axially chiral mixed S/N and S/P ligands
Efficient Syntheses of the Polyene Fragments Present in Amphidinols( )

1 edition published in 2007 in English and held by 2 WorldCat member libraries worldwide

2,2′,6-Tribromobiphenyl via Transition-Metal-Free ARYNE Coupling: A Valuable Tool in the Synthesis of Biphenyls( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Unintended Formation of a 26-Membered Cycle in the Course of a Novel Approach to Myricanol, a Strained [7,0]-Metacyclophane( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

 
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C-H activation for asymmetric synthesis CH-activation for asymmetric synthesis
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CH-activation for asymmetric synthesis
Alternative Names
Leuenberger, Françoise

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