WorldCat Identities

Bernard, Karen (1976-....).

Works: 1 works in 2 publications in 1 language and 2 library holdings
Roles: Author
Publication Timeline
Most widely held works by Karen Bernard
Identification et caractérisation de modulateurs de la sécrétion d'ions chlorure dans différents modèles cellulaires de l'épithélium bronchique humain by Karen Bernard( Book )

2 editions published in 2004 in French and held by 2 WorldCat member libraries worldwide

The airway epithelium secretes salt and fluid to maintain the optimal of the airway surface liquid. The CFTR CL-channel role in these transports is crucial as underlined by the discovery of CFTR gene mutations, which are responsible for the cystic fibrosis disease. A therapeutic approach would be to stimulate the activity of alternatives CL-channels to overcome the loss of functional CFTR. The aim of this study was to clarify the mechanisms underlying the regulation of these secretion pathways. This work shows the key role of SK4 channels in modulating airway epithelium CL-secretion. Their opening at the basolateral membrane of epithelial cells creates the driving force for CL-transport. In addition, their preferential location at the apical site of the goblet cells, which secrete mucins, suggest a specific role of these channels in this cellular population subtype. NACL transport of airways is under control of various factors such as neurotransmitters and extracellular nucleotides. This study is the first to report the stimulation of CL-seretion of a human bronchial epithelial cell line by neuropeptides belonging the arginin vasopressin family. The induced response is mediated by V1 and V2 receptors to vasopressin and the stimulated effectors are CFTR and SK4 channels. The stimulation of basolateral transporter activity us also supposed. This work also underlines the importance of purinergic P2Y6 receptors in the stimulation of anion secretion of the cellular models used in this study
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French (2)