WorldCat Identities

McCoy, Karen D.

Overview
Works: 21 works in 30 publications in 2 languages and 244 library holdings
Roles: Publishing director, Author, Other, Opponent, Contributor, Thesis advisor
Publication Timeline
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Most widely held works by Karen D McCoy
Tiques et maladies à tiques : biologie, écologie évolutive, épidémiologie by Albert Agoulon( )

7 editions published between 2015 and 2017 in French and Undetermined and held by 197 WorldCat member libraries worldwide

Présentes dans tous les écosystèmes, les tiques sont parmi les plus anciens arthropodes apparus sur Terre, exploitant leurs hôtes bien avant l'apparition de l'homme. Hématophages, elles sont responsables chez leurs hôtes d'une grande diversité de maladies, que ce soit par spoliation sanguine ou par transmission vectorielle de virus, de bactéries ou de parasites. Leur présence accrue dans l'environnement est à l'origine de nombreux cas d'encéphalites, de borrélioses de Lyme, de fièvres récurrentes, de babésioses ... Ainsi, les infestations par les tiques et les maladies qu'elles transmettent constituent un véritable problème de santé pour l'homme et pour les animaux domestiques, tant en zone tropicale que tempérée. Pour dresser un état des connaissances complet sur les tiques, cet ouvrage collectif adopte une approche pluridisciplinaire. Il décrit la systématique et l'évolution, la biologie et l'écologie des tiques ainsi que les relations complexes qu'elles entretiennent avec leur hôte. Les agents de maladies infectieuses transmis, les modes de transmission, les méthodes de prévention des risques ainsi qu'un état des lieux sur la lutte contre les tiques sont également présentés. Rédigé dans un langage accessible, ce livre constitue une référence actualisée sur un thème devenu un important enjeu de santé humaine et animale. Il est destiné aux étudiants, aux chercheurs, aux médecins et vétérinaires ainsi qu'aux autorités de santé
Tiques et maladies à tiques : biologie, écologie évolutive, épidémiologie( )

1 edition published in 2017 in French and held by 19 WorldCat member libraries worldwide

Présentes dans tous les écosystèmes, les tiques sont parmi les plus anciens arthropodes apparus sur Terre, exploitant leurs hôtes bien avant l'apparition de l'homme. Hématophages, elles sont responsables chez leurs hôtes d'une grande diversité de maladies, que ce soit par spoliation sanguine ou par transmission vectorielle de virus, de bactéries ou de parasites. Leur présence accrue dans l'environnement est à l'origine de nombreux cas d'encéphalites, de borrélioses de Lyme, de fièvres récurrentes, de babésioses... Ainsi, les infestations par les tiques et les maladies qu'elles transmettent constituent un véritable problème de santé pour l'homme et pour les animaux domestiques, tant en zone tropicale que tempérée. Pour dresser un état des connaissances complet sur les tiques, cet ouvrage collectif adopte une approche pluridisciplinaire. Il décrit la systématique et l'évolution, la biologie et l'écologie des tiques ainsi que les relations complexes qu'elles entretiennent avec leur hôte. Les agents de maladies infectieuses transmis, les modes de transmission, les méthodes de prévention des risques ainsi qu'un état des lieux sur la lutte contre les tiques sont également présentés. Rédigé dans un langage accessible, ce livre constitue une référence actualisée sur un thème devenu un important enjeu de santé humaine et animale. Il est destiné aux étudiants, aux chercheurs, aux médecins et vétérinaires ainsi qu'aux autorités de santé
A high gene flow in populations of Amblyomma ovale ticks found in distinct fragments of Brazilian Atlantic rainforest by Gislene F. S. R Fournier( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Impact of life stage-dependent dispersal on the colonization dynamics of host patches by ticks and tick-borne infectious agents by Sarah Kada( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Gene flow and adaptive potential in a generalist ectoparasite by Anaïs S. C Appelgren( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Host race formation in the Acari by Sara Magalhães( )

1 edition published in 2007 in English and held by 2 WorldCat member libraries worldwide

100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB by Julien Goebel( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Changing distributions of ticks: causes and consequences by Elsa Léger( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

The High Diversity and Global Distribution of the Intracellular Bacterium Rickettsiella in the Polar Seabird Tick Ixodes uriae by Olivier Duron( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

TESTING THE EFFECT OF CONSPECIFIC REPRODUCTIVE SUCCESS ON DISPERSAL AND RECRUITMENT DECISIONS IN A COLONIAL BIRD: DESIGN ISSUES by Thierry BOULINIER( )

1 edition published in 2002 in Undetermined and held by 1 WorldCat member library worldwide

Bioécologie et diversité génétique d'Orthops palus (Heteroptera, Miridae), ravageur du manguier à La Réunion by Morguen Atiama( )

1 edition published in 2016 in French and held by 1 WorldCat member library worldwide

Mango crops in Reunion Island are threatened by a series of pests, including the bug Orthops palus (Heteroptera, Miridae). This species has only been reported in Uganda and Reunion Island but is considered pest of mango only in Reunion Island. Few studies have therefore been devoted to this bug, which explains the lack of knowledge concerning this pest. The overall aim of my thesis was to acquire knowledge about O. palus, and several specific objectives were pursued. The first was to characterize mirid diversity in the mango orchards of Reunion Island. The second was to characterize the life cycle of O. palus and insect-plant interactions. The third objective was to study the distribution and genetic diversity of the species in Reunion Island and on other islands in the south-west Indian Ocean (SWIO).The main results of these studies are: among the 13 species identified in the community of mirids in mango orchards, O. palus was the most abundant on the mango inflorescences when in flower. Three original tools were built to identify O. palus in the laboratory and to recognize the species in the field: an identification key, COI sequences, and a field recognition card). A method was developed to rear O. palus, which enabled the characterization of its life cycle and the length of the development stages. Meanwhile, the inventory of in situ host plants (15 species in Reunion Island) showed that O. palus is polyphagous. Studies of the diversity and genetic structure of O. palus in SWIO islands also provided significant results. In Reunion Island, the population is structured in two clusters, although the structural factors could not be fully identified. In Mauritius, one cluster was identified and was shown to be different from the clusters in Reunion Island. No host race was found either in Reunion Island or in Mauritius. Population movements in both directions between the two islands were highlighted. Finally, the analysis of the mitochondrial DNA diversity of individuals sampled on four SWIO islands (Reunion, Mauritius, Mayotte, Grande Comore) revealed the presence of at least seven haplotypes whose distribution confirmed exchanges between islands.The dynamics of O. palus in space and over time are discussed in connection with its survival strategy over the course of the year and with population flows across SWIO. The results showed that beyond being a bug that attacks only the mango tree, as the name strongly suggests, O. palus is rather a "flower bug" likely to maintain populations throughout the year by moving from one flowering plant to another according to food availability. Among the plants involved in the annual dynamics of the insect, several species beside mango are of economic interest (lychee, jujube, avocado). Several research topics are proposed to complete the knowledge already acquired on O. palus, including understanding of population dispersion processes at the scale of the agro-ecosystem, and evaluating the presence and the genetic diversity of O. palus in other SWOI territories. Finally, agroecological practices for the local management of O. palus populations are proposed based on the results of the studies that comprise the present dissertation. Recommendations are made for precautionary measures to prevent the flow of O. palus populations between countries located in the Indian Ocean
Evolutionay consequences of the population structure of an ectoparasite at different spatial scales : an empirical approach of the hen flea-passerines system by Anais Appelgren( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

L'évolution divergente est un processus clef générant de la biodiversité. Elle peut avoir lieu entre localités, via la réduction des flux de gènes, et au sein des localités via la spécialisation écologique. Dans le cas des systèmes parasitaires multi-hôtes, l'adaptation dépend des taux relatifs de flux de gènes des hôtes et des parasites entre différentes localités, ainsi que des échanges locaux de parasites entre différents types d'hôtes. En combinant génétique des populations et expérimentations sur le système composé de la puce Ceratophyllus gallinae et deux de ses hôtes, la mésange charbonnière Parus major et le gobe-mouche à collier Ficedula albicollis dans un habitat fragmenté, nous avons examiné comment l'adaptation et l'isolation génétique façonnent l'évolution des parasites. Nous avons aussi testé comment les choix d'habitat des hôtes pouvaient influencer la rencontre avec des populations de parasites spécialisées. Les analyses de microsatellites révèlent que les populations de puce sont différenciées à une échelle spatiale fine, et fréquemment entre espèces hôtes. De plus, des populations de parasites semblent adaptées à chaque type d'hôte. Cependant, aucune variation dans les choix d'habitats par rapport aux parasites n'a été observée chez les hôtes. Enfin, la réponse des hôtes aux parasites variait entre nos deux zones réplica ; l'histoire des populations d'hôtes pourrait donc influer sur la coevolution avec leurs parasites. Ce système semble donc localement façonné à la fois par une isolation génétique et une sélection par différents hôtes. L'étude de nouveaux sites permettraient d'évaluer si cette évolution divergente peut être génératrice de biodiversité
Diversité génomique des bactéries pathogènes du complexe d'espèces Borrelia burgdorferi : évolution et épidémiologie moléculaire by Maude Jacquot( )

1 edition published in 2014 in French and held by 1 WorldCat member library worldwide

Infectious diseases are one of the major causes of human and animal morbidity, and they have impacts on the economy, public health, and the environment. By studying the diversity of the pathogens responsible for these diseases and their circulation within host communities and among vectors, we may glean valuable information that will aid prevention and control efforts. For these reasons, during my thesis, I became particularly interested in the pathogen(s) responsible for Lyme disease. This disease is caused by bacteria belonging to the Borrelia burgdorferi sensu lato (s.l.) species complex that are transmitted by ticks (during their blood meals) and that can infect several vertebrate host species. When I analyzed the genetic diversity present in 63 B. burgdorferi s.l. strains, whose genomes had been sequenced, I found that there was a significant degree of genetic separation among the different genospecies making up the complex. My results suggest that the fact that these different bacterial groups infect different ranges of hosts B. burgdorferi s.s. is mainly a pathogen of small mammals and B. garinii is primarily associated with birds lead to distinct population dynamics. Moreover, thanks to the high-throughput sequencing of two genetic markers, I have been able to show that, at an intraspecific level, certain B. burgdorferi genotypes are associated with specific rodent species. Finally, using the pathogen diversity observed in rodents and ticks, I employed a modeling approach to estimate the human disease risks presented by an introduced host species (the Siberian chipmunk) and found that these risks could be significant
Diversity, ecology and evolution of feather mites in seabirds = Diversidad, ecología y evolución de los ácaros de las plumas en aves marinas by Laura Mihaela Stefan( )

3 editions published between 2016 and 2017 in English and held by 1 WorldCat member library worldwide

Feather mites are among the most abundant and commonly occurring bird ectosymbionts. They live permanently on the host body, are adapted to inhabit well-defined host microhabitats and are found in almost all avian groups. Although feather mites have been extensively studied at the taxonomic level, much diversity remains undescribed and there are many open questions on the biology, ecology and evolution of feather mites. There is also an ongoing debate on the type of symbiosis, that is, whether bird-feather mite interactions are parasitic, commensalistic or even mutualistic. Therefore, better knowledge of feather mite communities at different levels of their biological organization (i.e., among host individuals, host populations and host species) can contribute to our understanding of the evolutionary ecology of feather mite-bird interactions, and of the evolution of parasite biodiversity in general. In this context, the main goal of this thesis was to investigate the evolutionary and ecological factors driving the diversity and community structure of feather mites inhabiting seabirds of the north-eastern Atlantic Ocean and Mediterranean Sea. More specifically, using a multi-host and multi-mite species community approach, I quantify feather mite morphological and genetic diversity within different seabird species and populations; evaluate the relative importance of host versus geographic structure in influencing the evolution and population structure of seabird feather mites; investigate the spatial distribution and trophic structure within a host individual to identify the driving mechanisms and proximate factors shaping symbiont infra-community structure. Based on morphological criteria, the results show that seabird species harbour a diverse and unique mite fauna composed of 38 species belonging to 10 genera and three families. All seabird species hosted at least three feather mite species, while the richest community was composed of nine mite species. Each seabird genus harboured a distinct feather mite community and only three mite species were shared by two related shearwater genera. Seventeen of the 38 mite species found were new, undescribed species; official descriptions of six are included in this thesis. Overall, molecular data correlated well with morphological species descriptions, but also revealed the presence of six putative cryptic species belonging to four mite genera. The patterns of mite genetic structure were variable both among different sympatric hosts and among the same host species in different geographic regions. Thus, the great majority of mite species from sympatric seabirds exhibited strong host-associated patterns of genetic structure. When comparing mite communities among sibling host species from the same genus, some mite species were genetically unstructured among hosts and localities, whereas other mite species showed higher degree of genetic diversity and among population differentiation. These observed differences correspond to microhabitat use on the host body. No genetic differentiation among localities was found for feather mites, suggesting that mite dispersal regularly occurs between host populations. The distribution of two widely abundant mite species that co-occur on the flight feathers of a single seabird species, Calonectris borealis, showed clear spatial segregation among feathers; one species preferred the central primaries, whereas the other was restricted to the outermost primaries. This pattern resulted from a combination of habitat-specific adaptations and ongoing competition. In addition, isotopic analyses of mite diet indicated that the two mite species share the same host food resources, probably preen gland oil complemented with exogenous material. Altogether, this thesis highlights the vast and largely unrecognized diversity of feather mites harboured by seabirds, provides a comprehensive characterization of the patterns of seabird-feather mite species/lineages associations and contributes to a better understanding of the ecological and evolutionary processes that have lead to their high diversity
Structure génétique et évolution de la spécialisation chez deux ectoparasites hématophages, les tiques Ixodes uriae et I. ricinus, vecteurs de la borréliose de Lyme by Florent Kempf( Book )

in French and held by 1 WorldCat member library worldwide

Many studies have been devoted to understanding the origin of life's vast diversity. In parasitic organisms, host specialization may be a key process in the emergence and maintenance of this diversity. Host and parasite life history traits can shape the spatial and temporal patterns of genetic variation, and thus, the possibility of host-associated divergence. In this thesis, we examine the evolution of host specialization in two host/parasite systems involving tick vectors of Lyme borreliosis: Ixodes uriae, a tick that exploits colonial seabirds in polar regions and, Ixodes ricinus, a tick with a large spectrum of terrestrial hosts in Europe. These congeneric species share many traits, but differ noticeably by the characteristics of the hosts they exploit and the strategies they use to encounter these hosts. Based on the basic biology of these ticks, we have formulated several hypotheses concerning the distribution of their genetic variation in natural populations and particularly among their local hosts. Ticks were sampled across a large spatial scale and were characterized using microsatellite and mitochondrial markers. We analyzed this data using different statistical tools frequently employed in phylogeography and population genetics, including some recently developed methods. Taken as a whole, our results support a scenario of recent and recurrent evolution of host races in I. uriae, where the local outcome of the interaction varies in space and among host species. Our results also suggest the existence of races specialized on different host types within I. ricinus populations (birds, rodents, lizards, etc), and a potential mechanism for assortative mating in these races. Overall, the work presented in this thesis highlights the importance of parasitic traits for the diversification process (dispersal, host encounter strategies, mate pair formation). More specifically, the frequent evolution of specific host races within tick populations will have importance consequences for the circulation of the pathogens they carry and, as such, calls into question our current understanding of the epidemiology of tick-borne diseases such as Lyme borreliosis
« Tiques et agents pathogènes transmis en Corse, milieu insulaire méditerranéen » by Sébastien Grech-Angelini( )

1 edition published in 2020 in French and held by 1 WorldCat member library worldwide

La Corse est une île méditerranéenne montagneuse présentant une grande diversité de biotopes. C'est également une région de chasse, de randonnée et d'élevage pratiqué de façon semi-extensive à extensive (bovins, ovins, caprins et porcins). Les interactions sont multiples entre l'homme, les animaux domestiques et la faune sauvage. Même si ce contexte apparait propice à l'implantation d'une grande diversité d'espèces de tiques et à la circulation des agents pathogènes qu'elles transmettent, ils n'avaient jamais fait l'objet d'une étude exhaustive. Le cheptel bovin insulaire, élevé dans un état de semi-liberté (avec une utilisation restreinte de traitements acaricides), est apparu comme un modèle approprié pour dresser un premier état des lieux des tiques présents sur le territoire insulaire. Durant une année, 1 938 tiques ont été collectées dans les trois abattoirs bovins de l'île. Huit espèces de tiques ont été identifiées : Rhipicephalus (Rh.) bursa (56% des tiques prélevées), Hyalomma (Hy.) marginatum (21%), Hy. scupense (9%), Ixodes (I.) ricinus (6%), Haemaphysalis (Ha.) punctata (5%), Rh. sanguineus sensu lato (2%), Rh. (Boophilus) annulatus (0,7%) et Dermacentor (D.) marginatus (0,3%). Le taux d'infestation des bovins est resté élevé toute l'année (63%), et plusieurs espèces de tiques ont montré des variations saisonnières de leur activité. Des collectes plus ponctuelles sur d'autres animaux domestiques (petits ruminants, chevaux, carnivores domestiques) et sauvages (sangliers, mouflons, cerfs, hérissons et oiseaux) ont permis la collecte de 3 134 tiques (dont 60% prélevées sur bovins). Une espèce supplémentaire, Ha. sulcata (collectée sur un mouflon), a été identifiée et des préférences claires d'infestation envers certains hôtes animaux ont été mises en évidence.Une puce à PCR micro-fluidiques en temps réel à haut débit (BioMarkTM dynamic arrays, Fluidigm Corporation, USA) a permis la recherche de 27 bactéries (issues des genres Borrelia, Anaplasma, Ehrlichia, Rickettsia, Bartonella, Candidatus Neoehrlichia, Coxiella et Francisella) et 12 espèces de parasites (issues des genres Babesia et Theileria) dans des pools composés d'une à cinq tiques. Près de la moitié (48%) des 569 échantillons (1 523 tiques analysées) étaient porteurs de l'ADN d'au moins un agent pathogène. Les séquences génétiques de 11 germes, dont sept sont zoonotiques, issus de six genres, ont été détectées. Tous les hôtes animaux prélevés ont présentés des tiques infectées et des agents pathogènes ont été détectés dans 80% de la zone échantillonnée. La présence de quatre agents pathogènes en Corse a ainsi été confirmée : Rickettsia aeschlimannii (23% des pools analysés), Rickettsia slovaca (5%), Anaplasma marginale (4%) et Theileria equi (0.4%), mais pour la plupart des agents pathogènes, leur ADN a été détecté pour la première fois en Corse : Anaplasma phagocytophilum (16%), Rickettsia helvetica (1%), Borrelia afzelii (0.7%), Borrelia miyamotoi (1%), Bartonella henselae (2%), Babesia bigemina (2%) et Babesia ovis (0.5%).Le virus de la fièvre hémorragique de Crimée Congo (CCHF) recherché de façon individuelle (dans ses tiques vectrices (genre Hyalomma) ou dans des tiques connues pour au moins le transporter (Rh. bursa) n'a pas été identifié mais une enquête sérologique réalisée sur 3 890 ruminants domestiques (bovins, caprins et ovins)a montré que 9,1% d'entre eux étaient porteurs d'anticorps dirigés contre le virus suggérant ainsi la circulation d'une souche virale en Corse. De prochaines études, notamment sérologiques, devront déterminer l'exposition réelle des populations humaines et animales aux agents pathogènes détectés et ainsi estimer leur potentiel impact médical et sanitaire en Corse
Identification of Ixodes ricinus female salivary glands factors involved in Bartonella henselae transmission by Xiangye Liu( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Ticks are obligate blood-feeding ectoparasites of many hosts including mammals, birds and reptiles. After mosquitoes, they are the most important vectors worldwide, and are able to transmit the highest variety of pathogens including virus, bacteria and parasites. Ixodes ricinus (Acari: Ixodidae), the most common tick species in Europe, is a three-life stage hard tick. It is frequently associated with bites in humans, and transmits several pathogens, including Tick-Borne Encephalitis, Babesia spp., Borrellia spp., Anaplasma spp., and to a lesser extent Bartonella spp. Bartonella spp. are facultative intracellular bacteria associated with a number of emerging diseases in humans and animals. It has been demonstrated that I. ricinus is a competent vector for B. henselae that causes cat scratch disease as well as being increasingly associated with a number of other syndromes, particularly ocular infections and endocarditis. Recently, emergence or re-emergence of tick-borne diseases (TBDs) is increasingly becoming a problem. Indeed, and because of the limited success and disadvantages of controlling TBDs via acaricides, new approaches are urgently needed. Therefore, vaccine strategies that target conserved components of ticks that play roles in vector infestation and vector capacity have become particularly attractive. Accordingly, the identification of suitable antigenic targets is a major challenge for the implementation of tick and TBDs control strategies. In the present work, the main objective is to elucidate molecular interactions between I. ricinus and B. henselae in order to identify some targets that may be used as vaccines against ticks and tick-borne pathogens. Two principal points are focused on: primarily, to identify I. ricinus salivary gland differentially expressed transcripts in response to B. henselae infection with next generation sequencing techniques (454 pyrosequencing and HiSeq 2000); secondly, to validate the implication of one of these transcripts in the transmission of B. henselae. For that purpose, and at first, we validated artificial membrane feeding technique for ticks infection by B. henselae and evaluated the impact of several parameters on tick feeding. Results showed that membrane feeding technique is a suitable method to infect I. ricinus with B. henselae and that the proportion and weight of engorged ticks are decreased by B. henselae infection of the blood meal. Transcriptional analysis of the tick salivary glands generated a reference databank containing 24,539 transcripts, and the comparison of B. henselae-infected and non-infected I. ricinus female salivary glands showed that 839 and 517 transcripts were significantly up- and down-regulated in response to bacteria infection, respectively. Among them, 161 transcripts corresponded to 9 groups of ticks salivary gland gene families already described, when the other ones corresponded to genes of unknown function. Silencing the most up-regulated gene IrSPI, which belongs to BPTI/Kunitz family of serine protease inhibitor, resulted in reduction of tick feeding and bacteria load in tick salivary gland. In conclusion, this work demonstrated that artificial-membrane feeding technique is a powerful tool for investigating the interactions between tick and tick-borne pathogens as B. henselae. It also increases the available genomic information for I. ricinus and the knowledge to improve our understanding of the molecular interaction between tick and tick-borne pathogens. At last, it provides a potential vaccine candidate to control tick-borne diseases. In the future, and depending of differentially expressed genes' role confirmation, more and more vaccine candidate will be provided by this work, and the strategy of controlling tick and tick-borne disease will come to a new stage
Intégrer les effets de la météorologie dans la modélisation de l'activité et de la survie des populations de tiques Ixodes ricinus dans le contexte du changement climatique by Julie Cat( )

1 edition published in 2017 in French and held by 1 WorldCat member library worldwide

The tick species Ixodes ricinus is a vector of major concern for animal and public health in Europe. Climate change will probably modify its activity time patterns. In the present and future bite risk assessment, weather-based models are required to predict tick activity. In this work a weather-based generalized linear regression model was fitted to tick count time series to predict the seasonal activity in I. ricinus nymphs. Using this model we simulated activity time series with climate change weather time series as inputs. A weather-based model was fitted to survival durations in I. ricinus females using a Bayesian estimation method. Simultaneously to modeling, we settled several observatories located in the climate areas encountered in mainland France to investigate the seasonal activity patterns of I. ricinus populations. Monthly tick collection was performed in routine from April 2014 to July 2016. I. ricinus behavior was investigated under conditions which are informative to assess the impact of climate change on activity. Both our observed and simulated results reinforce the hypothesis that activity periods will spread over winter under climate change. In summer season, activity was moderately high at some moments of the day, which underlined that the intra-day scale should be considered when assessing summer activity. The survival model successfully simulated the critical effect of dryness on female survival. In this work we highlighted the need i) to acquire observations under present conditions which are close to the ones projected under climate change, ii) to strengthen the sensitivity of population dynamic models to water availability in the close environment of ticks, and iii) to investigate the effects of the weather conditions undergone by ticks on their population dynamics at the inter-annual scale
Diversité génomique, évolution et adaptation de la tique Ixodes ricinus by Pierre Charrier( )

1 edition published in 2018 in French and held by 1 WorldCat member library worldwide

Les tiques sont des acariens hématophages vecteurs de nombreux micro-organismes dont certains sont responsables de maladies humaines ou animales (Borréliose de Lyme par exemple. La tique Ixodes ricinus, est largement distribuée en Europe où elle représente le principal vecteur de l'agent responsable de la maladie de Lyme. Trois volets ont été abordés au cours de cette thèse, en réalisant pour chaque point des séquençages à haut-débit de transcriptomes. Dans le premier volet, un catalogue de transcrits a été reconstruit et annoté à partir d'individus provenant de différentes conditions physiologiques (stades de développement, état de gorgement, sexe). Une analyse d'expression différentielle a permis de déterminer quels gènes sont exprimés plus spécifiquement lors du gorgement (protéines cuticulaires notamment, mais également métalloprotéases, etc...). Dans le deuxième volet, la structure génétique d'I. ricinus a été explorée à partir de douze populations Européennes. Mes résultats montrent pour la première fois un signal clair de structuration géographique, et d'isolation par la distance, à l'échelle de l'Europe. Dans le troisième volet, j'ai employé une approche phylogénomique sur le groupe des tiques dures : pour cela, j'ai reconstruit les transcriptomes de 27 espèces de tiques (dont neuf espèces séquencées pour ce projet) permettant de proposer un arbre phylogénétique très robuste pour ce groupe
 
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Alternative Names
Karen D McCoy onderzoeker

MacCoy, Karen D.

Mc Coy, Karen D.

Languages
French (13)

English (12)