WorldCat Identities

Brèthes, Daniel

Overview
Works: 10 works in 11 publications in 2 languages and 13 library holdings
Roles: Thesis advisor, Other, Author, Contributor, Opponent
Publication Timeline
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Most widely held works by Daniel Brèthes
Feeding mice with diets containing mercury-contaminated fish flesh from French Guiana: a model for the mercurial intoxication of the Wayana Amerindians by Jean-Paul Bourdineaud( )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

Etude structurale et fonctionnelle de la sous-unité h de la F1F0ATP synthase de la levure Saccharomyces cerevisiae by Rémi Fronzes( )

1 edition published in 2004 in French and held by 2 WorldCat member libraries worldwide

La F1 F0 ATP synthase est un complexe enzymatique situé au niveau de la membrane interne mitochondriale. La sous-unité h est une sous-unité de l'ATP synthase découverte en 1996 et localisée au niveau de la tige périphérique de l'enzyme. Le principal objectif des travaux présentés dans ce mémoire a été de déterminer la place de la sous-unité h dans la F1 F0 ATP synthase et de comprendre pourquoi cette sous-unité est essentielle à l'assemblage et/ou au fonctionnement de cet enzyme. Ainsi au cours de cette étude, il a été démontré que la sous-unité h est un composant majeur de la tige périphérique. De plus, une nouvelle fonction de la sous-unité h a été mise au jour. En effet, nous avons découvert que cette sous-unité est capable de se dimériser et semble fortement impliquée dans le processus de dimérisation de l'ATP synthase. Enfin, nous avons étudié les conséquences structurales et fonctionnelles de l'absence de la sous-unité h dans les cellules
Tentatives de reconstitution d'une membrane biologique : le reticulum sarcoplasmique by Daniel Brèthes( )

1 edition published in 1978 in French and held by 1 WorldCat member library worldwide

Localisation de l'ATP synthase mitochondriale et remaniement du réseau mitochondrial en quiescence by Laure Jimenez( )

1 edition published in 2014 in French and held by 1 WorldCat member library worldwide

Mitochondria form a dynamic tubular network which organization and distribution is highly regulated.Mitochondria are double membrane organites with a complex internal architecture. Cristae, which areinner membrane invaginations, are the site of oxidative phosphorylation, reactions by which ATP synthaseproduces ATP. ATP synthase also play a key role in cristae morphogenesis. In this study, I have shown thatATP synthase localized as discrete clusters along the mitochondrial network in living S. cerevisiae cellsgrown on a fermentable carbon source. Overall our data suggest that ATP synthase clusers correspond tomitochondrial cristae, opening new avenues to explore the mechanisms involved in inner membraneremodelling.Mitochondrial network morphology is regulated by a dynamic equilibrium between the fusion and fissionof mitochondrial tubules. In the second part of my thesis, I highlight a progressive mitochondrialfragmentation during quiescence establishment, a state defined as a reversible absence of proliferation.Quiescent cells mitochondrial network is composed of immobile small cortical mitochondrial vesicles witha variable enzymatic content. Upon quiescence exit, cortical mitochondrial vesicles rapidly fuse and atubular network is reconstituted prior to bud emergence. Astonishingly, neither the canonical fusion orfission machineries nor the actin cytoskeleton are required for the mitochondrial network modificationduring quiescence / proliferation transition
Impact d'un sédiment dopé aux nanoparticules d'or ou de sulfure de cadmium sur un invertébré et un poisson d'eau douce by Amina Dedeh( )

1 edition published in 2014 in French and held by 1 WorldCat member library worldwide

The aim of this thesis was to determine the impact of two types of metal nanoparticles (cadmium sulphide - CdS - and gold - Au) on two aquatic models (tubifex worms and zebrafish Danio rerio). The approach has been to dope the Garonne sediment with the two types of nanoparticles and characterize the effect of this contamination on the two animals using multiple markers at different levels of biological organization (biochemical responses, neurotransmission activity, genotoxicity, gene expression and bioturbation activity). The effects were evaluated after exposure to contaminated sediment in experimental microcosms systems for twenty days. In a number of cases this work revealed an effect of the nanoparticles that was not due to metal but to the nanoparticulate properties. Indeed, in the case of CdS nanoparticles, we observed alterations in the genome as well as the modification of the bioturbation activity of worms tubifex in response to the contamination of nanoparticles but not to that of the ionic form. In this work we observed the release of gold nanoparticles from the sediment into the water column, and its potential bioavailability to fish. These nanoparticles were causing DNA damage in both organisms, modifying the expression of certain genes and increased acetylcholinesterase activity in zebrafish. Bioturbation results showed no effects of gold nanoparticles on the movement of worms
Regulation of mitochondrial ATPase by its inhibitor protein IF1 in Saccharomyces cerevisiae by Qian Wu( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Etudes des propriétes électrostatiques de surface de la membrane du reticulum sarcoplasmique by Daniel Brèthes( )

1 edition published in 1985 in French and held by 1 WorldCat member library worldwide

Etude de la fonction des sous-unités h, d et f du pied périphérique de la F1F0ATP-synthase mitochondriale de la levure Saccharomyces cerevisiae by Vanessa Goyon( )

1 edition published in 2008 in French and held by 1 WorldCat member library worldwide

Impact d'une contamination au méthylmercure par voie alimentaire sur l'expression génétique, la bioénergétique, et la reproduction chez le poisson zèbre Danio rerio by Sébastien Cambier( )

1 edition published in 2009 in French and held by 1 WorldCat member library worldwide

The effects of methylmercury contamination on the zebrafish, Danio rerio, were assessed in two tissues, the skeletal muscle and the central nervous system, whose choice was motivated by their high potential to bioaccumulate this organometallic. After contamination by dietary, at a representative exposure level of which may arise in some aquatic ecosystems, our experimental observations indicate that metal strongly disrupts the mitochondrial metabolism in the muscles, but savings that the brain; in addition, the gene expression analysis suggests a disruption of the calcium homeostasis in these two tissues. In the central nervous system among glutamatergique and GABAnergique synapses, only the metabolic pathway of the GABA seems to show an adaptation to the MeHg. Concerning the skeletal muscle scanning SAGE analysis helped to understand the impacts of the MeHg at the cellular scale. It is also revealing a disruption of the protein synthesis, the induction of a stress at the endoplasmic reticulum level as well as the induction of several genes involved in detoxification process and general stress response. Our study has also highlighted the induction of the vitellogenin gene in the muscle of male fish designating this metal as an endocrine disruptor. Finally, we have also revealed a significant disruption of hatching eggs associated with maternal transfer of this toxic
 
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