WorldCat Identities

Médigue, Claudine

Overview
Works: 39 works in 43 publications in 2 languages and 69 library holdings
Roles: Contributor, Other, Thesis advisor, Opponent, Author
Publication Timeline
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Most widely held works by Claudine Médigue
CONCEPTION ET EXPLOITATION D'UNE BASE DE DONNEES SPECIALISEE DEDIEE A L'ANALYSE DU GENOME D'ESCHERICHIA COLI by Claudine Médigue( Book )

1 edition published in 1991 in French and held by 3 WorldCat member libraries worldwide

L'EXPLOITATION DES DONNEES DE SEQUENCES ACQUISES AU COURS DU SEQUENCAGE DE GENOMES CELLULAIRES ENTIERS SUPPOSE LA CONSTRUCTION DE BASE DE DONNEES INTEGRANT A LA FOIS LES DONNEES BRUTES ISSUES DU SEQUENCAGE ET L'EXPERTISE DES BIOLOGISTES A PROPOS DE CHACUN DES GENES REPERTORIES. LE TRAVAIL PRESENTE DANS CETTE THESE A POUR OBJECTIF L'ELABORATION D'UN ENVIRONNEMENT INFORMATIQUE PERMETTANT D'ORGANISER, DE GERER ET D'EXPLOITER UN ENSEMBLE DE DONNEES BIOLOGIQUES ISSUES D'UN MEME ORGANISME. DANS UN PREMIER TEMPS, LE DEVELOPPEMENT D'UNE BASE DE DONNEES SPECIALISEE AUTOUR DU GENOME D'ESCHERICHIA COLI NOUS A CONDUIT A DEFINIR UN MODELE DE STRUCTURATION DES DONNEES PERMETTANT DE PRENDRE EN COMPTE DES CONNAISSANCES JUSQU'A PRESENT MAL STRUCTUREES RELATIVES A L'ORGANISATION DU CHROMOSOME BACTERIEN. CE MODELE DEVRAIT ETRE APPLICABLE A L'ETUDE D'AUTRES ORGANISMES PROCARYOTES. NOUS AVONS PAR AILLEURS MIS EN UVRE DIVERSES METHODES INFORMATIQUES PERMETTANT D'EXPLOITER LA BASE DE DONNEES. LES RESULTATS BIOLOGIQUES QUE NOUS DECRIVONS CONCERNENT L'ANALYSE DES DONNEES DE LA CARTE GENETIQUE ET PHYSIQUE D'E. COLI ET LA CARACTERISATION DES GENES CONNUS DE LA BACTERIE REPERTORIES DANS LA BASE EN FONCTION DE LEUR UTILISATION DES CODONS. TROIS CLASSES DE GENES ONT AINSI ETE IDENTIFIEES QUI SE DISTINGUENT A LA FOIS PAR LEUR FONCTION ET PAR LEUR STRUCTURE. EN PARTICULIER L'UNE DE CES CLASSES EST ESSENTIELLEMENT COMPOSEE DE GENES IMPLIQUES DANS LES ECHANGES HORIZONTAUX. CE RESULTAT NOUS A CONDUIT A ANALYSER DANS LE DETAIL LES PROPRIETES SPECIFIQUES DES CLASSES DE GENES D'E. COLI QUI SONT COMPAREES A CELLES QUE NOUS OBTENONS POUR B. SUBTILIS ET S. CEREVISIAE. CES ETUDES DEVRAIENT NOUS PERMETTRE DE CARACTERISER LES CONTRAINTES SPECIFIQUES QUI AGISSENT SUR LES SEQUENCES NUCLEOTIDIQUES ET AINSI DE MIEUX COMPRENDRE L'ORGANISATION DU TEXTE GENOMIQUE DE CHACUN DE CES ORGANISMES
(Ré)annotation de génomes procaryotes complets : exploration de groupes de gènes chez les bactéries by Stéphanie Bocs( Book )

2 editions published in 2004 in French and held by 3 WorldCat member libraries worldwide

The entomopathogenic bacterial endosymbionts Xenorhabdus and Photorhabdus: convergent lifestyles from divergent genomes( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

Distinct co-evolution patterns of genes associated to DNA polymerase III DnaE and PolC by Stéfan Engelen( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Growth of Yersinia pseudotuberculosis in human plasma: impacts on virulence and metabolic gene expression by Marie-Laure Rosso( )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

16S rRNA and As-Related Functional Diversity: Contrasting Fingerprints in Arsenic-Rich Sediments from an Acid Mine Drainage by Anne Fahy( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Units of plasticity in bacterial genomes: new insight from the comparative genomics of two bacteria interacting with invertebrates, Photorhabdus and Xenorhabdus by Jean-Claude Ogier( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Genomes of three tomato pathogens within the Ralstonia solanacearum species complex reveal significant evolutionary divergence by Benoît Remenant( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Comparative genomics of the core and accessory genomes of 48 Sinorhizobiumstrains comprising five genospecies by Masayuki Sugawara( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Développements méthodologiques pour l'identification in silico des métalloprotéines dans les protéomes bactériens : le cas des protéines à centre Fer-Soufre by Johan Estellon( )

1 edition published in 2012 in French and held by 2 WorldCat member libraries worldwide

Up to 40% of all proteins are known to bind metals, the intrinsic metal atoms providing catalytic, regulatory and/or structural roles critical to their functions. These metalloproteins are ubiquitous and of major importance within the three domains of life. However, current methods dedicated to identifying members of this large family within bacterial proteomes are either not suitable for large-scale approach or are of relatively limited performance when no 3D structural template is available. Within this context, different sequence analysis tools relying on different category of protein descriptors (e.g. patterns, conserved domains, phylogenetic prints) were assessed. To overcome their relative lack of sensibility, new descriptors, specific towards iron-sulfur proteins identification were built: (i) co-conservation profiles of the metal ligands and (ii) tailored profile-HMMs for remote homologs detection. Their respective predictive power towards the identification of a manually curated iron-sulfur proteins dataset were assessed, either separately or in combination. All relevant descriptors were finally gathered into a generalized linear model by using the elastic-net method. The predictive model has been evaluated on Escherichia coli whole proteome resulting in a precision of 89% and a recall of 83%. Eventually, it has been applied to 300 proteomes allowing investigating different biological relationships, such as iron-sulfur proteins relative abundances and the oxygen dependency of bacterial organisms
A new network representation of the metabolism to detect chemical transformation modules by Maria Sorokina( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Comparative and functional genome analysis of Acidithiobacillus bacteria by Thi thanh tam Tran( )

2 editions published in 2016 in English and held by 2 WorldCat member libraries worldwide

The acidophilic Acidithiobacillus bacteria play an important role in industrial biomining operations for metal recovery. In this thesis, the genome sequence of a psychrotolerant Acidithiobacillus ferrivorans CF27 were first refined. The comparative genome analysis between CF27 and the closely related Acidithiobacillus genomes revealed: (i) a syntenic conservation of two tRNA array units which are only present in At. ferrivorans CF27 and At. ferrooxidans ATCC 23270 genomes and mainly contribute to the tRNA gene redundancy in both organisms. Moreover, our large-scale genome survey of the tRNA array units in prokaryotic organisms showed that tRNA arrays appear in few phyla; (ii) a high proportion of species-specific genes in CF27 and SS3 strains indicated the high variability of gene content in Acidithiobacillus genomes and therefore the unique nature of each group of species. Given that mRNA expression of some CF27 specific genes were confirmed in Fe(II)-grown cells and sulfur attached cells in CF27, these results highlighted the functional importance of specific genes for CF27 lifestyle; and (iii) the mosaic taxonomic composition of members of the Acidithiobacillia class, and thus confirmed that this group belongs to a particular taxonomic class, distinct to other proteobacterial groups. Taken together, our results provide insights into At. ferrivorans lifestyle as well as the chimeric genome nature of the Acidithiobacillus organisms. In addition, I also participated to the 'Thioredoxin reductase' project which aims to define the biochemical function, molecular structure and evolution of TRi, an atypical thioredoxin reductase
Expansion of the SOS regulon of Vibrio cholerae through extensive transcriptome analysis and experimental validation by Evelyne Krin( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitidis by Christophe Rusniok( )

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

Small variable segments constitute a major type of diversity of bacterial genomes at the species level by Fabrice Touzain( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Profiling the orphan enzymes by Maria Sorokina( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

Genomic and physiological analysis reveals versatile metabolic capacity of deep-sea Photobacterium phosphoreum ANT-2200 by Sheng-Da Zhang( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Extensive recombination events and horizontal gene transfer shaped the Legionella pneumophila genomes by Laura Gomez-Valero( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

Contrasting effects of historical contingency on phenotypic and genomic trajectories during a two-step evolution experiment with bacteria by Jessica Plucain( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

GROOLS: reactive graph reasoning for genome annotation through biological processes by Jonathan Mercier( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

 
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Languages
English (18)

French (4)