Troussard, Xavier
Overview
| Works: | 33 works in 40 publications in 2 languages and 71 library holdings |
|---|---|
| Roles: | Contributor, Thesis advisor, Other, Opponent, Author, 956 |
| Classifications: | RB145, 616.15 |
Publication Timeline
.
Most widely held works by
Xavier Troussard
Europe China cultural compass orientation for cultural cooperation between China and Europe by
K Hellkötter(
Book
)
1 edition published in 2011 in English and held by 8 WorldCat member libraries worldwide
The Europe-China Cultural Compass provides orientation for cultural cooperation between Europe and China with informed background knowledge from experienced authors and commentators on cultural policy, cultural and creative industries, arts disciplines and themes, society, media, legal frameworks, value systems and intercultural cooperation issues
1 edition published in 2011 in English and held by 8 WorldCat member libraries worldwide
The Europe-China Cultural Compass provides orientation for cultural cooperation between Europe and China with informed background knowledge from experienced authors and commentators on cultural policy, cultural and creative industries, arts disciplines and themes, society, media, legal frameworks, value systems and intercultural cooperation issues
Optimisation de nanostructures plasmoniques pour la détection et la caractérisation structurelle des protéines par Diffusion
Raman Exaltée de Surface by
Maximilien Cottat(
Book
)
3 editions published in 2014 in French and held by 4 WorldCat member libraries worldwide
Proteins play an important role in cells via their enzymatic activity and the irinteractions. Their functions are mainly based on the protein structure. In order to detect their presence and to characterize their structure, we used optical properties of nanostructures. The localized surface plasmon resonance (LSPR), as well as the surface enhanced Raman scattering (SERS), allowed us to detect various proteins. We also optimized nanostructures to build a sensitive, reproducible and specific biosensor based on SERS. Indeed, specific detection of one pathological biomarker, the Manganese Super Oxide Dismutase (MnSOD) protein, was investigated by using optically optimized and aptamer-functionalized nanostructures. Using this system, we were able to detect the MnSOD at physiological concentration in body fluids, such as serum and saliva. Finally, the structural study of the Spleen Tyrosine kinase (Syk) protein by SERS, allowed us to demonstrate that its structure varied with its phosphorylation levels. A complementary Western Blot analysis showed that the Syk kinase activity depended also on its phosphorylation state, meaning that the structure and the activity of Syk were linked. Altogether, these data contributed to a better understanding of the interface between physics and biology
3 editions published in 2014 in French and held by 4 WorldCat member libraries worldwide
Proteins play an important role in cells via their enzymatic activity and the irinteractions. Their functions are mainly based on the protein structure. In order to detect their presence and to characterize their structure, we used optical properties of nanostructures. The localized surface plasmon resonance (LSPR), as well as the surface enhanced Raman scattering (SERS), allowed us to detect various proteins. We also optimized nanostructures to build a sensitive, reproducible and specific biosensor based on SERS. Indeed, specific detection of one pathological biomarker, the Manganese Super Oxide Dismutase (MnSOD) protein, was investigated by using optically optimized and aptamer-functionalized nanostructures. Using this system, we were able to detect the MnSOD at physiological concentration in body fluids, such as serum and saliva. Finally, the structural study of the Spleen Tyrosine kinase (Syk) protein by SERS, allowed us to demonstrate that its structure varied with its phosphorylation levels. A complementary Western Blot analysis showed that the Syk kinase activity depended also on its phosphorylation state, meaning that the structure and the activity of Syk were linked. Altogether, these data contributed to a better understanding of the interface between physics and biology
Behavioural insights applied to policy : European report 2016(
Book
)
3 editions published in 2016 in English and held by 3 WorldCat member libraries worldwide
The report covers a wealth of policy applications either implicitly or explicitly informed by behavioural insights (BIs). It reviews institutional developments and puts forward a comparative framework (PRECIS) describing behavioural insight teams with six key features. The report reaches four main conclusions: 1. in terms of capacity-building, there is significant dynamism and growing appetite to apply BIs to policy-making; 2. links between policy-making and academy communities can be strengthened and analysing large datasets offers great potential; 3. systematic application of BIs throughout the policy cycle can advance evidence-based policy-making; 4. need of more research on the long-term impacts of policy interventions
3 editions published in 2016 in English and held by 3 WorldCat member libraries worldwide
The report covers a wealth of policy applications either implicitly or explicitly informed by behavioural insights (BIs). It reviews institutional developments and puts forward a comparative framework (PRECIS) describing behavioural insight teams with six key features. The report reaches four main conclusions: 1. in terms of capacity-building, there is significant dynamism and growing appetite to apply BIs to policy-making; 2. links between policy-making and academy communities can be strengthened and analysing large datasets offers great potential; 3. systematic application of BIs throughout the policy cycle can advance evidence-based policy-making; 4. need of more research on the long-term impacts of policy interventions
Thrombopénies à l'héparine : à propos de six observations personnelles by
Xavier Troussard(
Book
)
1 edition published in 1984 in French and held by 3 WorldCat member libraries worldwide
1 edition published in 1984 in French and held by 3 WorldCat member libraries worldwide
Apport du séquençage haut débit de gènes ciblés dans la leucémie à tricholeucocytes : mise en évidence d'un nouveau
gène altéré, KDM6A, dans la forme variante de la maladie by
Elsa Maitre(
)
2 editions published in 2018 in French and held by 3 WorldCat member libraries worldwide
La mutation BRAFV600E est retrouvée dans plus de 80% des cas de leucémie à tricholeucocytes (HCL). Récemment des mutations additionnelles à BRAFV600E ont été mises en évidence. Un panel de 21 gènes d'intérêts (appelé Trichopanel) a été sélectionné à partir de la revue de la littérature des données de Whole Exome Sequencing. Nous avons analysé 20 patients atteints d'HCL et 4 formes variantes (HCL-v) au diagnostic (dont 5 paires diagnostic/rechute). Le Trichopanel a été informatif dans 96% (23/24) des patients et a révélé des mutations dans BRAF (n=18), KLF2 (n=4), MAP2K1 (n=3), KDM6A (n=2), CDKN1B (n=2), ARID1A (n=2), CREBBP (n=2) NOTCH1 (n=1) et ARID1B (n=1). Parmi les patients porteurs de la mutation BRAFV600E d'autres mutations ont été trouvées dans 33% des cas (6/18). Les fréquences alléliques de ces mutations étaient proche de celle de BRAFV600E suggérant qu'elles sont d'apparition précoce. Les 4 patients HCL-v présentaient des mutations dans les gènes de la régulation épigénétique dont KDM6A (n=2). Ces mutations induiraient la perte du domaine C-terminal, hautement conservé et essentiel pour l'activité déméthylase de la protéine. L'inactivation de KDM6A pourrait sensibiliser les cellules tumorales aux agents déméthylants tel que les inhibiteurs d'EZH2. Cinq patients (2HCL et 3 HCL-v) ont été analysés parallèlement au diagnostic et à la rechute/évolution. L'analyse des prélèvements a la rechute a montré une évolution clonale de la maladie. Le Trichopanel est un outil facile d'utilisation en routine, utile à la fois pour le diagnostic initial et la rechute des patients HCL et HCL-v
2 editions published in 2018 in French and held by 3 WorldCat member libraries worldwide
La mutation BRAFV600E est retrouvée dans plus de 80% des cas de leucémie à tricholeucocytes (HCL). Récemment des mutations additionnelles à BRAFV600E ont été mises en évidence. Un panel de 21 gènes d'intérêts (appelé Trichopanel) a été sélectionné à partir de la revue de la littérature des données de Whole Exome Sequencing. Nous avons analysé 20 patients atteints d'HCL et 4 formes variantes (HCL-v) au diagnostic (dont 5 paires diagnostic/rechute). Le Trichopanel a été informatif dans 96% (23/24) des patients et a révélé des mutations dans BRAF (n=18), KLF2 (n=4), MAP2K1 (n=3), KDM6A (n=2), CDKN1B (n=2), ARID1A (n=2), CREBBP (n=2) NOTCH1 (n=1) et ARID1B (n=1). Parmi les patients porteurs de la mutation BRAFV600E d'autres mutations ont été trouvées dans 33% des cas (6/18). Les fréquences alléliques de ces mutations étaient proche de celle de BRAFV600E suggérant qu'elles sont d'apparition précoce. Les 4 patients HCL-v présentaient des mutations dans les gènes de la régulation épigénétique dont KDM6A (n=2). Ces mutations induiraient la perte du domaine C-terminal, hautement conservé et essentiel pour l'activité déméthylase de la protéine. L'inactivation de KDM6A pourrait sensibiliser les cellules tumorales aux agents déméthylants tel que les inhibiteurs d'EZH2. Cinq patients (2HCL et 3 HCL-v) ont été analysés parallèlement au diagnostic et à la rechute/évolution. L'analyse des prélèvements a la rechute a montré une évolution clonale de la maladie. Le Trichopanel est un outil facile d'utilisation en routine, utile à la fois pour le diagnostic initial et la rechute des patients HCL et HCL-v
Hématologie by
Société française d'hématologie(
Book
)
1 edition published in 2014 in English and held by 3 WorldCat member libraries worldwide
Le contenu, clair et didactique, est étayé par de nombreux tableaux et des points clés sur des notions à retenir et illustré par une riche iconographie en couleur. Cette première partie intègre les fondements de la discipline, avec une sous-partie intitulée "Introduction à l'hématologie" qui développe davantage les notions fondamentales à acquérir par les étudiants lors des premières années (niveau DFGSM) ; une partie Entraînement qui propose 17 dossiers progressifs et 139 QRM, offrant un véritable outil d'auto-évaluation ; en fin de chapitre, les points clés sont davantage développés et les "notions indispensables" introduites pour une préparation optimale aux ECNi. [Ed.]
1 edition published in 2014 in English and held by 3 WorldCat member libraries worldwide
Le contenu, clair et didactique, est étayé par de nombreux tableaux et des points clés sur des notions à retenir et illustré par une riche iconographie en couleur. Cette première partie intègre les fondements de la discipline, avec une sous-partie intitulée "Introduction à l'hématologie" qui développe davantage les notions fondamentales à acquérir par les étudiants lors des premières années (niveau DFGSM) ; une partie Entraînement qui propose 17 dossiers progressifs et 139 QRM, offrant un véritable outil d'auto-évaluation ; en fin de chapitre, les points clés sont davantage développés et les "notions indispensables" introduites pour une préparation optimale aux ECNi. [Ed.]
Recommendations of the SFH (French Society of Haematology) for the diagnosis, treatment and follow-up of hairy cell leukaemia by
Edouard Cornet(
)
1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide
Survival benefit of mantle cell lymphoma patients enrolled in clinical trials; a joint study from the LYSA group and French
cancer registries by
Alix Augustin(
)
1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide
Visions for the World in 2035 workshop with the future leaders EDD15 / European Development Days(
)
2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide
The workshop "Visions for the World in 2035" was organised in the EU Policy Lab by the Foresight and Behavioural Insights Unit in collaboration with the European Development Days (EDD15). It hosted 15 Future Leaders between the ages of 21 and 26 who were selected by the EDD15 organisers from around the world to join the debate on development policy and international cooperation. The purpose of the workshop was 1) to introduce the Future Leaders to systemic and long-term strategic thinking, 2) to help them formulate a vision broadly related to their area of activity and thus boost their contribution to the upcoming EDD15 debates, and 3) to foster their positioning as agents of positive change in the coming decades. Through group vision building, plenary discussions and individual pitches, participants shared their experiences, explored megatrends that are likely to shape different possible futures and challenged present assumptions related to social change, youth and development. The aim of the report is to present our insights from the preparation and running of the workshop in order to revise different methods and techniques used and adapted in the context of the EU Policy Lab. This type of an event could be further adapted and replicated in other research and policy contexts
2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide
The workshop "Visions for the World in 2035" was organised in the EU Policy Lab by the Foresight and Behavioural Insights Unit in collaboration with the European Development Days (EDD15). It hosted 15 Future Leaders between the ages of 21 and 26 who were selected by the EDD15 organisers from around the world to join the debate on development policy and international cooperation. The purpose of the workshop was 1) to introduce the Future Leaders to systemic and long-term strategic thinking, 2) to help them formulate a vision broadly related to their area of activity and thus boost their contribution to the upcoming EDD15 debates, and 3) to foster their positioning as agents of positive change in the coming decades. Through group vision building, plenary discussions and individual pitches, participants shared their experiences, explored megatrends that are likely to shape different possible futures and challenged present assumptions related to social change, youth and development. The aim of the report is to present our insights from the preparation and running of the workshop in order to revise different methods and techniques used and adapted in the context of the EU Policy Lab. This type of an event could be further adapted and replicated in other research and policy contexts
Label free technologies: Raman micro-spectroscopy and multi-spectral imaging for lymphocyte classification by
Teddy Happillon(
)
1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide
Prolymphocytic Leukemia: New Insights in Diagnosis and in Treatment by
Aude Collignon(
)
1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide
Prediction of patients with multiple myeloma eligible for second- or third-line treatment in France by
Virginie Rondeau(
)
1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide
How Can Behavioural Insights Be Used to Improve EU Policy? by
Xavier Troussard(
)
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
Incidence and characteristics of chronic renal replacement therapy in patients with cancer: data from kidney and cancer registries
in Basse-Normandie by
Clémence Béchade(
)
1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide
Le lymphome du MALT de localisation pulmonaire : à propos de 8 observations by
Heidi Laviec(
Book
)
1 edition published in 1998 in French and held by 2 WorldCat member libraries worldwide
1 edition published in 1998 in French and held by 2 WorldCat member libraries worldwide
Leucémie à tricholeucocytes et infection à mycobacterium avium intracellulaire by
Pascale Briens(
Book
)
1 edition published in 1998 in French and held by 2 WorldCat member libraries worldwide
1 edition published in 1998 in French and held by 2 WorldCat member libraries worldwide
Effets fonctionnels des mutations de KDM6A dans la leucémie à tricholeucocytes by
Margaux Wiber(
)
2 editions published between 2020 and 2021 in French and held by 2 WorldCat member libraries worldwide
La leucémie à tricholeucocytes (HCL) et sa forme variante (HCL-v) sont des syndromes lymphoprolifératifs B caractérisés par des mutations de BRAF et de MAP2K1 responsables d'une activation anormale de la voie des MAP-kinases. Des mutations additionnelles à ces anomalies drivers ont été identifiées. Nous nous sommes intéressés au gène KDM6A qui code pour une lysine déméthylase exerçant un rôle de suppresseur de tumeur. Sa perte d'expression sensibiliserait les cellules tumorales aux inhibiteurs d'EZH2, une méthyltransférase. Afin d'étudier l'impact fonctionnel de l'inactivation de KDM6A dans la HCL, nous avons transfecté un système CRISPR-Cas9 ciblant l'exon 4 du gène dans la lignée cellulaire JVM-3. La perte d'expression de KDM6A dans cette lignée favorise l'activation de la voie des MAPK sans modifier les capacités prolifératives des cellules, ni leur sensibilité aux inhibiteurs de BRAF. Les cellules éditées présentent une meilleure résistance à la privation en nutriments concordante avec une augmentation de l'expression de la survivine. Il n'a pas été observé de sensibilité accrue des cellules modifiées aux thérapies ciblant l'épigénétique incluant les inhibiteurs d'EZH2. L'inactivation de KDM6A paraît ainsi concourir à l'activation de la voie oncogénique des MAPK dans la HCL mais modifie peu les capacités des tricholeucocytes et leur réponse aux chimiothérapies et thérapies ciblées
2 editions published between 2020 and 2021 in French and held by 2 WorldCat member libraries worldwide
La leucémie à tricholeucocytes (HCL) et sa forme variante (HCL-v) sont des syndromes lymphoprolifératifs B caractérisés par des mutations de BRAF et de MAP2K1 responsables d'une activation anormale de la voie des MAP-kinases. Des mutations additionnelles à ces anomalies drivers ont été identifiées. Nous nous sommes intéressés au gène KDM6A qui code pour une lysine déméthylase exerçant un rôle de suppresseur de tumeur. Sa perte d'expression sensibiliserait les cellules tumorales aux inhibiteurs d'EZH2, une méthyltransférase. Afin d'étudier l'impact fonctionnel de l'inactivation de KDM6A dans la HCL, nous avons transfecté un système CRISPR-Cas9 ciblant l'exon 4 du gène dans la lignée cellulaire JVM-3. La perte d'expression de KDM6A dans cette lignée favorise l'activation de la voie des MAPK sans modifier les capacités prolifératives des cellules, ni leur sensibilité aux inhibiteurs de BRAF. Les cellules éditées présentent une meilleure résistance à la privation en nutriments concordante avec une augmentation de l'expression de la survivine. Il n'a pas été observé de sensibilité accrue des cellules modifiées aux thérapies ciblant l'épigénétique incluant les inhibiteurs d'EZH2. L'inactivation de KDM6A paraît ainsi concourir à l'activation de la voie oncogénique des MAPK dans la HCL mais modifie peu les capacités des tricholeucocytes et leur réponse aux chimiothérapies et thérapies ciblées
Persistent polyclonal binucleated B-cell lymphocytosis and MECOM gene amplification by
Édouard Cornet(
)
1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide
Résistance à l' apoptose et régulation du cycle cellulaire dans le lymphome splénique à lymphocytes villeux (SLVL) by
Mikaël Roussel(
Book
)
1 edition published in 2002 in French and held by 2 WorldCat member libraries worldwide
1 edition published in 2002 in French and held by 2 WorldCat member libraries worldwide
The effect of patient characteristics on second primary cancer risk in France by
Jérémie Jégu(
)
1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide
more
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Audience Level
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Related Identities
- SpringerLink (Online service) Other
- Université de Caen UFR de médecine Degree grantor
- Feng, Guoling Contributor
- Burke, Joanna
- Hou, Hanru Contributor
- Lu, Carol Yinghua Contributor
- Knopp, Hans-Georg 1945-
- Xinyan, Song Translator
- Zhang, Qiuzao Contributor
- Oehler, Irene Contributor
Associated Subjects
