WorldCat Identities

Provot, Olivier

Overview
Works: 15 works in 18 publications in 2 languages and 28 library holdings
Roles: Contributor, Thesis advisor, Author, Opponent, Other
Publication Timeline
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Most widely held works by Olivier Provot
SYNTHESE ENANTIOSPECIFIQUE DE LA (3S,5R,8S)-3-HEPTYL-5-METHYLPYRROLIZIDINE, CONSTITUANT DU VENIN DE LA FOURMI SOLENOPSIS XENOVENENUM by Olivier Provot( Book )

2 editions published in 1991 in French and held by 4 WorldCat member libraries worldwide

LA SYNTHESE ENANTIOSPECIFIQUE DE L'ENANTIOMERE (3S,5R,8S) D'UN ALCALOIDE D'INSECTE 3-HEPTYL-5-METHYLPYRROLIZIDINE ET LA PREPARATION DE PYRROLIDINES TRANS DISUBSTITUEES A ETE REALISEE A PARTIR DE L'ACIDE (S)-PYROGLUTAMIQUE
Synthèse d'hétérocycles azotés quinoléiques et quinazoliniques à visée antileishmanienne by Jöel Dade( Book )

2 editions published in 2004 in French and held by 3 WorldCat member libraries worldwide

This thesis consists in the synthesis of nitrogen heterocyclic compounds derived from quinolines and quinazolines. These compounds are structurally analogues to natural quinolines, the chimanines, having antileishmanial activity. During this work we have prepared about a hundred quinolinic and quinazolinic compounds and we have evaluated their activity against Leishmania donovani donovani and Leishmania amazonensis strains. Biological evaluation against Plasmodium falciparum is currently carry out. We also studied the reactivity of quinazolines substituted at the 2 position by an epoxy group towards nucleophilic reagents such as organolithium, Grignard reagents and amino compounds
Conception, synthèse et évaluation biologique de nouveaux agents anti-mitotiques et anti-vasculaires, analogues de la combréstatine A-4 by Anne Giraud( Book )

2 editions published in 2008 in French and held by 2 WorldCat member libraries worldwide

L'angiogenèse constitue une étape essentielle de la croissance tumorale et de la dissémination métastatique, assurant à la tumeur son apport en nutritions et oxygène et son essaimage. Le concept selon lequel la croissance tumorale peut être inhibée en supprimant l'angiogénèse tumorale a suscité le développement de nouvelles stratégies ciblant les vaisseaux sanguins de la tumeur. Deux stratégies thérapeutiques sont possibles : l'une consiste à inhiber la formation des néovaisseaux par le recours à des agents anti-angiogéniques (AIA) et l'autre vise à la désorganisation rapide des néovaisseaux existants par l'utilisation d'agents anti-vasculaires (VDA). Parmi les VDA, un groupe prometteur est composé de molécules inhibant la polymérisation de la tubuline. La combrétastatine A4 (CA-4), leur chef de file, est actuellement en développement clinique de phase II sous la forme d'une pro-drogue phosphate (CA-4P). L'objectif de cette thèse a été de synthétiser puis d'évaluer in vitro des nouveaux analogues de la CA-4. Nous avons réalisé des pharmacomodulations au niveau de l'espaceur qui lie les deux noyaux aromatiques. Il nous a paru intéressant de moduler, au niveau de ce lien, le nombre d'atomes de carbone (4, 6, 2, 1) ainsi que la nature de leur hybridation (Csp, Csp2, Csp3). Parmi tous ces analogues, une tête de série, l'isoCA-4, présentant des activités biologiques in vitro similaires à celles de la CA-4 a été identifié. Son évaluation biologique in vivo est actuellement en cours
Synthesis of Isocoumarin via PTSA-Catalyzed Annulation of Diarylalkynes( )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

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1 edition published in 2006 in English and held by 2 WorldCat member libraries worldwide

Tributyltin Hydride in NMP-Promoted Reduction of Acid Chlorides to Aldehydes under Transition-Metal-Free Conditions( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Iron-Catalyzed Coupling Reaction between 1,1-Dichloro-1-alkenes and Grignard Reagents( )

1 edition published in 2004 in English and held by 2 WorldCat member libraries worldwide

Synthesis of Substituted Benzils from Diarylalkyne Oxidation( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

A Convenient Metal-Free Synthesis of (E)-3-Styrylisocoumarins through Annulation of (E)-1,4-Diarylenynes( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Regiochemical Aspects of the Platinum Oxide Catalyzed Hydrosilylation of Alkynes( )

1 edition published in 2007 in English and held by 2 WorldCat member libraries worldwide

réactions inattendues de réduction régiosélectives de benziles et de arylalkyldicétones by Ling-Zhi Yuan( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

In this work, we have described that, for the first time the TMSCl - NaI association was used to regioselectively reduce a variety of alpha diketones as benzils in methylene chloride. Moreover, we showed that this association was able to reduce various arylalkylketones as well as alpha ketoesters, ketoacids and hydrazinoesters with total selectivity. The mechanism of action is probably due to radicals was fully studied with many experiments
PtO2/PTSA system catalyzed regioselective hydration of internal arylalkynes bearing electron withdrawing groups1( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Abstract : A highly efficient PtO2 /PTSA catalyst system for the hydration of a wide array of alkynes was developed. Abstract : A highly efficient PtO2 /PTSA catalyst system for the hydration of a wide array of alkynes was developed. This method proved to be compatible with a large range of functional groups and the ketone products were obtained in high yields. The scope of this methodology was also extended to the synthesis of 3-aryl-isochromenones, -indoles and -benzofurans
Reduction of thioketals by TMSCl/NaI association and synthesis of heterocycles from ortho-substituted arylalkynes by Guangkuan Zhao( )

1 edition published in 2019 in English and held by 1 WorldCat member library worldwide

This thesis is divided into two distinct parts. The first show that, after a comprehensive study of thioketals desulfurization reactions listed in the literature, the use of TMSCl / NaI combination is a modern method of choice to reduce thioketals since it does not require any toxic metal. In a second part, we have been interested in the synthesis of heterocycles (isocoumarins, benzothiophenes and indoles) by the study of original heterocyclization reactions. The thesis is presented with the presentation and discussion of publications (7)
Conception, synthèse et évaluation biologique d' analogues contraints de l'isocombrétastatine a-4 à visée antitumorale by Evelia Rasolofonjatovo( )

1 edition published in 2011 in French and held by 1 WorldCat member library worldwide

Most tumor cells rely on an efficient vascular supply for their survival, making the tumor vasculature an attractive target for anti-cancer therapy. This thesis aimed at the design and synthesis of constrained analogues of isocombretastatin A-4(isoCA-4), an antivascular agent developed in the laboratory, which exerts excellent cytotoxicities against a large panel ofcancer cell lines, and strongly inhibits tubulin polymerization. Conformationally restricted analogues of isoCA-4,featuring 1-arylnaphthalene, 5-arylbenzoxepine or 4-arylchromene skeletons were designed by computational studies andprepared by novel synthetic strategies. Of all synthesized compounds, benzoxepine analogue 3-53 strongly inhibits tubulinpolymerization and shows excellent cytotoxicities against several human cancer cell lines
Conception, synthèse et évaluation de nouveaux composés hétérocycliques analogues de l'isoCombrétastatine A-4 : vers des composés antivasculaires à effets secondaires amoindris by Ilhem Khelifi( )

1 edition published in 2018 in French and held by 1 WorldCat member library worldwide

Combretastatin A-4 (CA-4), is a natural antivascular agent isolated from a South African Sallow tree that selectively destroys tumor vasculature leading to ischemic necrosis. In 2016, the prodrug fosbretabulin (CA-4P) obtained designation as orphan drug in USA and Europe for the treatment of neuroendocrine tumors and glioblastoma. Despite its importance as a therapeutic agent, fosbretabulin has shown chemical instability. In fact, the double bond form Z isomerizes to an inactive E form of the drug. Moreover, fosbretabulin is associated to several side-effects including cardiotoxicity. Our group succeeded in the design of a more stable and non-isomerizable form of CA-4 as isoCA-4 which exhibited similar biological activities as CA-4. It was thought that cardiotoxicity of CA-4 and analogs is probably due to the presence of the 3,4,5-trimethoxyphenyl A-ring however the latter seems to have an essential role for the cytotoxic and antitubulin activities of the drug. Despite the role of the trimethoxyphenyl ring, we have focused our challenges on the remplacement of this moiety by various heterocycles to reduce the cardiotoxicity and to put an end to this dogma. We have identified three new classes of heterocyclic and bis-heterocyclic antivascular agents. We have demonstrated that these "drug-like" molecules have excellent antiproliferative activities at nanomolar ranges, an antivascular activity superior to that of CA-4 and possesses a very high cardiac safety index. Regarding these results, we have been able to show for the first time that the replacement of the 3,4,5-trimethoxyphenyl ring of isoCA-4 by various heterocyclic systems is a promising approach to synthesize new antivascular agents having a low level of cardiotoxicity
 
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Languages
English (10)

French (8)