WorldCat Identities

Galicier, Lionel

Overview
Works: 23 works in 24 publications in 2 languages and 40 library holdings
Roles: Thesis advisor, Other, Contributor, Author
Publication Timeline
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Most widely held works by Lionel Galicier
Caractéristiques et prise en charge de l'anémie hémolytique auto-immune au cours de l'infection par le VIH : série rétrospective de 28 cas by Clément Gourguechon( Book )

2 editions published in 2015 in French and held by 3 WorldCat member libraries worldwide

Introduction : L'anémie est une anomalie biologique fréquemment retrouvée au cours de l'infection par le VIH, et peut être associée à une positivité du Test Direct à l'Antiglobuline (TDA), sans qu'il n'existe d'hémolyse associée. L'Anémie Hémolytique Auto-Immmune (AHAI) est rarement décrite au cours de l'infection par le VIH. Matériels et Méthodes : Les observations cliniques et données biologiques des patients suivis dans notre centre pour une infection par le VIH avec un diagnostic associée d'anémie hémolytique ont examinés pour inclusion. Résultats : Nous avons revus les dossiers de 82 patients. Le diagnostic d'AHAI était retenu chez 28 patients. Il s'agissait majoritairement d'hommes (71,4%). L'âge moyen au diagnostic d'AHAI était de 42,2 ±10,4 ans. Le taux moyen d'hémoglobine de 4,8 ±1,8 g/dl au nadir. Il s'agissait d'AHAI à auto-anticorps chauds chez 26 patients et de type mixte dans 2 cas. Une pathologie associée au Virus Herpes Humain 8 était retrouvée chez 22 patients dont 95 % avaient une Maladie de Castleman alors que 3 patients avaient un lymphome et 2 une maladie autoimmune. Vingt-trois patients (82,1%) ont été traités par corticothérapie. Un traitement de 2e ligne était nécessaire chez 22 patients (splénectomie=9, rituximab=12) et 26 ont reçu un traitement étiologique. 92,8 % des patients étaient répondeurs en fin de suivi dont 82,1% de Réponse Complète. Conclusion : L'AHAI au cours de l'infection par le VIH est fréquemment associée à une pathologie sousjacente, comme la MC, un lymphome, ou une maladie auto-immune. Les traitements de l'AHAI semblent efficaces et bien tolérés chez les patients infectés par le VIH, bien qu'un traitement spécifique est le plus souvent nécessaire
Maladie de Castleman multicentrique non associée à l'infection VIH : une ou plusieurs maladies? by Antoine Dossier( Book )

in French and held by 2 WorldCat member libraries worldwide

Résultats de la réanimation dans les lymphomes associés au VIH by Constance Guillaud Danis( Book )

1 edition published in 2010 in French and held by 2 WorldCat member libraries worldwide

Les lymphomes associés au VIH (LAV) se différencient des lymphomes survenant dans la population générale par une présentation clinique plus agressive, des formes rares, spécifiques de l'infection VIH, et un pronostic sombre. Depuis l'avènement des thérapies combinées antirétrovirales (cART), l'incidence des LAV a diminuée, mais dans le même temps ils sont devenus une des premières causes de mortalité chez les patients infectés par le VIH. Grâce aux cART et à l'utilisation de chimiothérapies à fortes doses, leur pronostic s'améliore. Cependant, la survie reste inférieure à celle des lymphomes des sujets séronégatifs. Il existe de nombreuses situations pouvant conduire les patients atteints d'un LAV en réanimation, mais aucune donnée n'existe sur les résultats de la réanimation chez ces patients. Cette étude, rétrospective, descriptive, et monocentrique est la première à s'intéresser aux patients atteints d'un LAV et admis en réanimation. Sur une période de 10 ans, 76 patients présentant un LAV en première ligne ont été inclus. L'analyse de leurs caractéristiques montre qu'ils présentent des lymphomes agressifs, disséminés, et qu'ils sont mal contrôlés sur le plan du VIH. Les taux de mortalité en réanimation et hospitalière sont respectivement de 34% et 44%. Les facteurs associés à la mortalité hospitalière en analyse multivariée sont l'âge, l'entrée pour coma et le recours aux amines vasopressives. Ainsi, la mortalité à court terme des patients ayant un LAV en réanimation ne diffère pas de celui des patients d'onco-hématologie, et les facteurs pronostiques du lymphome et de l'infection VIH n'influencent pas la survie hospitalière. Ces éléments ne doivent alors pas influencer la décision d'admission en réanimation
FIBROSE RETROPERITONEALE ET MALADIES SYSTEMIQUES by Lionel Galicier( Book )

1 edition published in 1999 in French and held by 2 WorldCat member libraries worldwide

Intravascular lymphoma presenting as a specific pulmonary embolism and acute respiratory failure: a case report by Sophie Georgin-Lavialle( )

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

HHV8-related hemophagocytic syndrome: diagnosis is in the eye by Sandrine Valade( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Déficit sélectif en IgM : manifestations cliniques et caractéristiques immunologiques chez 10 patients by Claire Aguilar( Book )

1 edition published in 2010 in French and held by 2 WorldCat member libraries worldwide

Le déficit sélectif en IgM n'est pas individualisé dans la classification internationale des déficits immunitaires primitifs. Les données de la littérature suggèrent une association avec diverses manifestations infectieuses, allergiques et auto-immunes. Nous avons étudié les manifestations cliniques et les caractéristiques immunologiques des patients inclus dans les cohortes DEFI et CEREDIH ayant un déficit sélectif en IgM. 29 patients étaient inclus dans ces cohortes avec un diagnostic d'hypo IgM ; 19 ont été exclus car il avaient un déficit en sous-classes d'IgG ou en IgA associé, un dosage des sous-classes non renseigné ou un déficit immunitaire complexe associé. 10 patients avaient un déficit sélectif en IgM. 50% des patients ont présenté au moins une infection sévère, comprenant des infections à pneumocoque mais également à d'autres bactéries à cocci gram positif (streptocoques et staphylocoque doré). Ces infections sévères ne semblaient pas corrélées au taux d'IgM sérique. L'anomalie la plus fréquente sur le phénotypage lymphocytaire était une diminution des lymphocytes B de la zone marginale (8 patients). Le déficit sélectif en IgM est rare. Dans notre série, les infections sévères à pneumocoque sont fréquentes mais ne semblent pas récidivantes chez un même patient. Ces infections sévères justifient une prophylaxie anti-infectieuse par les vaccinations, avec une évaluation de la réponse vaccinale. L'éducation du patient sur la conduite à tenir en cas de fièvre est également un élément important de la prise en charge
Rapid identification and characterization of infected cells in blood during chronic active Epstein-Barr virus infection by Benjamin Fournier( )

1 edition published in 2020 in English and held by 2 WorldCat member libraries worldwide

Abstract: Epstein-Barr virus (EBV) preferentially infects epithelial cells and B lymphocytes and sometimes T and NK lymphocytes. Persistence of EBV-infected cells results in severe lymphoproliferative disorders (LPDs). Diagnosis of EBV-driven T or NK cell LPD and chronic active EBV diseases (CAEBV) is difficult, often requiring biopsies. Herein, we report a flow-FISH cytometry assay that detects cells expressing EBV-encoded small RNAs (EBERs), allowing rapid identification of EBV-infected cells among PBMCs. EBV-infected B, T, and/or NK cells were detectable in various LPD conditions. Diagnosis of CAEBV in 22 patients of Caucasian and African origins was established. All exhibited circulating EBV-infected T and/or NK cells, highlighting that CAEBV is not restricted to native American and Asian populations. Proportions of EBV-infected cells correlated with blood EBV loads. We showed that EBV-infected T cells had an effector memory activated phenotype, whereas EBV-infected B cells expressed plasma cell differentiation markers. Thus, this method achieves accurate and unambiguous diagnoses of different forms of EBV-driven LPD and represents a powerful tool to study their pathophysiological mechanisms
Critical care management of patients with hemophagocytic lymphohistiocytosis by Sophie Buyse( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Le syndrome d'activation lympho-histiocytaire au cours de l'infection par le VIH by Sandrine Gazaignes( Book )

1 edition published in 2011 in French and held by 2 WorldCat member libraries worldwide

Objective : To describe clinical and diagnostic features of HLM in HIV-infected patients. To compare characteristics of underlying diseases and to research prognostic factors. Results : Seventy five medical charts of HLH in HIV-infected patients fulfilling Janka's criteria between january 2000 and january 2009 were reviewed. Median age was 41 years (21-72). Fifty-eight (78%) patients were men and 41% originated from Africa. The median lymphocyte CD4 count was 132/ul and 13 (17%) patients had a plasma HIV RNA below 50 copies/ml. After extensive diagnostic procedures, an associated disease could be detected in all patients. Underlying diseases were : 35 (47%) multicentric Castleman diseases, 15 (20%) Hodgkin lymphomas, 6 (8%) B-cell lymphomas, 3 (4%) T- cell lymphomas, 12 (16%) mycobacterial infections, 2 (2,5%) disseminated toxoplasmosis and 2 (2,5%) systemic diseases. Patients with multicentric Castleman disease presented more frequently with Kaposi sarcoma or posititve HHV-8 DNA detection (p inferior 0.000 1). Uderlying condition was identified in 91% of lymph nodes biopsies, 49% of bone marrow biopsies and 47 % of liver biopsies. Median follow-up time was 31 months. The estimated 1-year and 5-years survival were 64% and 53% repectively. Mortality was greater in patients with OMS 3 or 4, or with lymphoma. (p inferior 0.05). Summary : HLH in HIV infected patients is frequently associated with multicentric Castleman disease, lymphoma or mycobacterial infection. Lymph node or multiple tissue biopsies are useful diagnostic procedures for underlying disease. The prognosis remains poor and depends on the HLH aetiology
The clinical features of cardiac involvement in patients with severe thrombotic thrombocytopenic purpura by Aude-Marie Fourmont( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

A 1-Year Prospective French Nationwide Study of Emergency Hospital Admissions in Children and Adults with Primary Immunodeficiency by the CEREDIH French PID study group( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Persistent risk of adult T-cell leukemia/lymphoma after neonatal HTLV-1 infection through exchange transfusion by Eric Oksenhendler( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Uterine intravascular lymphoma as a cause of fever of unknown origin by Jérôme Hadjadj( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Macrovascular thrombosis in critically ill patients with thrombotic micro-angiopathies by Laurent Camous( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Lupus enteritis: from clinical findings to therapeutic management by Peter Janssens( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Coagulation Disorders and Bleedings in Critically Ill Patients With Hemophagocytic Lymphohistiocytosis( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

<Title><x>Abstract</x></title><sec><title>Abstract</title>Reactive hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition related to a cytokine storm leading to multiorgan dysfunction. A better understanding of coagulation disorders, frequently reported in HLH patients, may improve outcomes. Critically ill HLH patients managed in a multidisciplinary national reference center were retrospectively included. Relationships between coagulation disorders, severe bleedings, and outcomes were assessed. One hundred and seventeen patients fulfilled the HLH 2004 criteria. The most common HLH etiology was hematologic conditions (73%), followed by infectious diseases (20%), systemic rheumatic diseases (5%), and undetermined HLH etiology (3%). All patients exerted thrombocytopenia. Coagulation disorders were diagnosed in 79 (68%) patients (61 had hypofibrinogenemia <1.5 g/L, 51 had prothrombin time [PT] <50%). The worst median value throughout ICU stay was 52% (38-65) for PT with a factor V level of 35% (27-43), 1.59 (1.30-2.09) for the activated partial thromboplastin time (APTT) ratio, and 2.33 g/L (1.13-3.86) for the fibrinogen level. Disseminated intravascular coagulation (DIC) was found in 50% of patients. Coagulation disorders were more frequent in immunocompromised patients, those with histological/cytological feature of hemophagocytosis, those with the highest ferritin concentrations, and in patients with HLH not related to infection. These patients were more prone to receive mechanical ventilation, vasopressors, or renal replacement therapy. Twenty-six (22%) patients presented severe bleeding complications, including 5 patients dying from hemorrhagic shock. Strikingly, the only coagulation parameter significantly associated with severe bleeding was low fibrinogen with a cutoff value of 2 g/L (<italic>P</italic> = 0.03). Overall, 33 (28%) patients died in the ICU and hospital mortality was 44%. Coagulation disorders were associated with higher mortality, especially fibrinogen <2 g/L (<italic>P</italic> = 0.04) and PT value (<italic>P</italic> = 0.03). The occurrence of bleeding complications was not associated with higher risk of hospital death. Risk factors associated with mortality by multivariate analysis were fibrinogen level <2 g/L (OR 2.42 [1.08-5.41]), SOFA score> 6 (OR 3.04 [1.32-6.98]), and age> 46 years (OR 2.26 [1.02-5.04]). Up to two-third of critically ill HLH patients present with coagulation disorders. Hypofibrinogenemia or DIC was found in half of the patients and low PT in 40%. These patients require more life support and have a higher mortality rate. Fibrinogen <2 g/L is associated with the occurrence of severe bleeding and mortality.</sec>
Development and Validation of the HScore, a Score for the Diagnosis of Reactive Hemophagocytic Syndrome( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

Abstract Objective Because it has no unique clinical, biologic, or histologic features, reactive hemophagocytic syndrome may be difficult to distinguish from other diseases such as severe sepsis or hematologic malignancies. This study was undertaken to develop and validate a diagnostic score for reactive hemophagocytic syndrome. Methods A multicenter retrospective cohort of 312 patients who were judged by experts to have reactive hemophagocytic syndrome (n = 162), were judged by experts to not have reactive hemophagocytic syndrome (n = 104), or in whom the diagnosis of reactive hemophagocytic syndrome was undetermined (n = 46) was used to construct and validate the reactive hemophagocytic syndrome diagnostic score, called the HScore. Ten explanatory variables were evaluated for their association with the diagnosis of hemophagocytic syndrome, and logistic regression was used to calculate the weight of each criterion included in the score. Performance of the score was assessed using developmental and validation data sets. Results Nine variables (3 clinical [i.e. known underlying immunosuppression, high temperature, organomegaly], 5 biologic [i.e. triglyceride, ferritin, serum glutamic oxaloacetic transaminase, and fibrinogen levels, cytopenia], and 1 cytologic [i.e. hemophagocytosis features on bone marrow aspirate]) were retained in the HScore. The possible number of points assigned to each variable ranged from 0-18 for known underlying immunosuppression to 0-64 for triglyceride level. The median HScore was 230 (interquartile range [IQR] 203-257) for patients with a positive diagnosis of reactive hemophagocytic syndrome and 125 (IQR 91-150) for patients with a negative diagnosis. The probability of having hemophagocytic syndrome ranged from <1% with an HScore of d"0 to>99% with an HScore of e"50. Conclusion The HScore can be used to estimate an individual's risk of having reactive hemophagocytic syndrome. This scoring system is freely available online (http://saintantoine.aphp.fr/score/)
Reply( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Rectal Lymphogranuloma Venereum in HIV-infected Patients Can Mimic Lymphoma( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract : An outbreak of rectal lymphogranuloma venereum (LGV) has been reported since 2003 in men who have sex with men, most of them being infected with human immunodeficiency virus. In these patients, unusual clinical presentations such as rectal tumor or intense lymphoproliferation on rectal biopsies may lead to an erroneous diagnosis of aggressive non-Hodgkin lymphoma. Three patients were referred to our center for the management of rectal B-cell non-Hodgkin lymphoma on the basis of a rectal pathologic specimen showing intense lymphoproliferation, the very suspect of lymphoma. Because of anamnesis of anal intercourses and venereal diseases, additional study revealed that all 3 had a positive Chlamydia trachomatis polymerase chain reaction on the rectal biopsy specimen. Rectal LGV was therefore considered and successfully treated with antibiotics. We propose that all patients presenting with a suspected rectal lymphoma should have a careful anamnesis of sexual behavior and a specific detection of C. trachomatis using polymerase chain reaction analysis on biopsy specimen to rule out the possibility of rectal LGV
 
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English (14)

French (7)