WorldCat Identities

Porcheray, Fabrice

Works: 5 works in 6 publications in 2 languages and 9 library holdings
Roles: Author
Publication Timeline
Most widely held works by Fabrice Porcheray
Activations classiques et alternatives des macrophages et des cellules microgliales dans l'infection à VIH : implications pour l'inflammation et la neurotoxicité by Fabrice Porcheray( Book )

2 editions published in 2005 in French and held by 3 WorldCat member libraries worldwide

Les troubles neurologiques souvent observés au stade avancés du SIDA constituent une complication importante de la maladi et peuvent mener à lamort du patient. Les macrophages et la microglie sont les seules cellules capables de supporter une infection productive dans le cerveau. Ces cellules sont connues pour leurs propriétés neurotoxiques, via la production de médiateurs pro-inflammatoires et le relarguage de divers neurotoxines, parmi lesquelles le glutamate. Cependant, des études récentes suggèrent également des propriétés neuroprotectrices pour les macrophages et la microglie, qui expriment les transporteurs du glutamate et peuvent donc limiter sa concentration dans la fente synaptique. Dans cette étude, nous avons caractérisé les activations pro- et anti-inflammatoires des macrophages et étudiés leurs effets sur le comportement de ces cellules vis-à-vis de l'infection. Ensuite, les conséquences de l'environnement inflammatoire sur les propriétés neuroprotectrices des macrophages, via la détoxification du glutamate, ont été évaluées. Ce travail met en évidence les interrelations entre les macrophages, l'inflammation et le métabolisme du glutamate, ainsi que les conséquences sur le stress oydant généré lors de l'infection
Type I interferon-mediated autoinflammation due to DNase II deficiency by Mathieu P Rodero( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Nerve growth factor stimulation promotes CXCL-12 attraction of monocytes but decreases human immunodeficiency virus replication in attracted population by Boubekeur Samah( )

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

Dynamics of B Cell Recovery In Kidney/Bone Marrow Transplant Recipients( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract : Background: Previous studies identified B cell gene signatures and predominance of specific B cell subsets as a marker of operational tolerance after kidney transplantation. These findings suggested a role for B cells in the establishment or maintenance of tolerance. Here we analyzed B cell recovery in 4 subjects, 3 of whom achieved tolerance after combined kidney/bone marrow transplantation. Methods: Peripheral B cell subsets were examined longitudinally by flow cytometry. Immunoglobulin heavy chain repertoire analysis was performed using next-generation sequencing. Lastly, the patients' serum reactivity to HLA was assessed by Luminex. Results: B cell counts recovered approximately 1 year posttransplant except for 1 subject who experienced delayed reconstitution. This subject resumed immunosuppression for acute rejection at 10 months posttransplant and underwent preemptive retransplantation at 3 years for chronic rejection. B cell recovery was accompanied by a high frequency of CD20 + CD24 high CD38 high transitional B cells and a diversified clonal repertoire. However, all 4 subjects showed prevalence of CD20 + CD27+ memory B cells around 6 months posttransplant when B cell counts were still low and the clonal B cell repertoire very limited. The predominance of memory B cells was also associated with high levels of somatically mutated immunoglobulin heavy chain variable sequences and transient serum reactivity to HLA. Conclusions: Our observations reveal the presence of memory B cells early posttransplant that likely escaped the preparative regimen at a time consistent with the establishment of tolerance. Further studies are warranted to characterize the functional properties of these persisting memory cells and evaluate their potential contribution to tolerance induction. Abstract : In 3 tolerant renal transplant recipients after kidney and bone marrow transplantation, memory B cells were predominant early posttransplantation when tolerance was evolving. While transitional B cells increased only after immunosuppression withdrawal raising doubts regarding their roles during tolerance induction. Supplemental digital content is available in the text

1 edition published in 2000 in French and held by 1 WorldCat member library worldwide

Audience Level
Audience Level
  General Special  
Audience level: 0.00 (from 0.00 for Activation ... to 0.00 for Activation ...)