WorldCat Identities

Authier, François-Jérôme (1961-....).

Overview
Works: 20 works in 24 publications in 2 languages and 34 library holdings
Roles: Thesis advisor, Other, Author, Contributor, Opponent
Publication Timeline
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Most widely held works by François-Jérôme Authier
FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis by Axel Van Der Gucht( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Cytochrome c oxidase deficiency in the muscle of patients with zidovudine myopathy is segmental and affects both mitochondrial DNA- and nuclear DNA-encoded subunits by Mohammed Yerroum( )

1 edition published in 2000 in English and held by 2 WorldCat member libraries worldwide

Production d'interleukine-1 par la cellule musculaire squelettique by François-Jérôme Authier( Book )

2 editions published in 1997 in French and held by 2 WorldCat member libraries worldwide

L'INTERLEUKINE (IL)-1 EST UNE MOLECULE PLEIOTROPE CONNUE COMME MEDIATEUR PROXIMAL DE L'INFLAMMATION MAIS EGALEMENT IMPLIQUEE DANS LE REMODELAGE TISSULAIRE. NOUS AVONS MIS EN EVIDENCE UNE PRODUCTION D'IL-1 ET DE SES MESSAGERS PAR LES FIBRES MUSCULAIRES, AU COURS DE LA MYOPATHIE A L'AZT, DANS DIVERSES PATHOLOGIES MUSCULAIRES CARACTERISEES PAR UNE PROTEOLYSE MYOFILAMENTAIRE IMPORTANTE (DERMATOMYOSITE, ATROPHIE ET FIBRES EN CIBLES NEUROGENES, MYOPATHIE DE REANIMATION) ET AU NIVEAU DU DOMAINE POST-SYNAPTIQUE DES JONCTIONS NEUROMUSCULAIRES DANS LE MUSCLE NORMAL. NOUS AVONS OBSERVE UNE LOCALISATION DE L'IL-1 AU NIVEAU DES MEMBRANES MITOCHONDRIALES, ET UNE CONSTANTE EXPRESSION D'IL-1 DANS LES FIBRES EN VOIE DE REGENERATION EXPRIMANT NCAM/NKH1-LEU 19. CES RESULTATS NOUS ONT CONDUIT A EXPLORER LA PRODUCTION DES ACTEURS DU SYSTEME IL-1 AU COURS DE LA MYOGENESE IN VITRO (IL-1, IL-1, IL-1RA, IL-1RI, IL-1RII, ICE). NOUS AVONS OBSERVE UNE EXPRESSION DIFFERENTIELLE DES COMPOSANTS DE LA FAMILLE DE L'IL-1 AU COURS DE LA MYOGENESE IN VITRO. L'ENTREE DES MYOBLASTES DANS LE PROCESSUS DE FUSION S'ACCOMPAGNE D'UN MAXIMUM D'EXPRESSION DE L'IL-1 ET DE SES RECEPTEURS. UNE PREMIERE ETAPE DANS LA COMPREHENSION DU ROLE DE L'IL-1 DANS LA MYOGENESE FUT D'ETUDIER LES EFFETS DE L'IL-1 ET DE L'IL-1RA EXOGENES SUR LA DIFFERENCIATION MYOGENIQUE : L'IL-1 A UN EFFET INHIBITEUR SUR LA PROLIFERATION ET LA DIFFERENCIATION DES MYOBLASTES, EFFET ANTAGONISE PAR L'IL-1RA. EN CONCLUSION, NOS TRAVAUX INDIQUENT QU'IL EXISTE UNE PRODUCTION CONSTITUTIVE D'IL-1 PAR LA CELLULE MUSCULAIRE STRIEE SQUELETTIQUE ET QUE L'IL-1 SEMBLE IMPLIQUEE DANS LE PROCESSUS DE DIFFERENCIATION MYOGENIQUE
Complications locales et manifestations générales chez des patientes porteuses d'implants mammaires PIP® by Marie Bouillot( )

2 editions published in 2017 in French and held by 2 WorldCat member libraries worldwide

Context : silicone breast implants (SBI) safety remains contested despite favorable epidemiological studies. In 2010, the evidence that PIP® manufacturer used fraudulent silicone revived controversy. PPP (Patientes Porteuses d'IM PIP®) Association was founded to defend the rights of victims. The leaders of PPP Association observed that several association's members presented with general symptoms (GS) in addition to local complications of SBI, leading them to set up a survey that was sent to all PPP members. In this present study, we analyzed the results of this survey and tried to characterize GS typology and evaluate whether GS associated with the presence of SBI dysfunctioning or local complications (LC). Methods : among the 306 answers collected, 284 were eligible for analysis, including 168 women with GS ('symptomatic' group; 59%) and 116 without GS ('asymptomatic' group; 41%). Subgroups 'aesthetic surgery' and 'reconstruction' were defined according to SBI indication. Results : most frequent GS included fatigue (79.8%), muscle (61.3%) and joint (58.3%) pain, and cognitive complaints (50.6%). SBI dysfunctioning associated with the occurrence of LC and GS (p<0,0001). Dysfunctioning and LC were 3 fold more frequent in symptomatic group. The rate of dysfunctioning and LC was comparable between 'aesthetic surgery' and 'reconstruction' groups. Conclusion : this study is suggestive of a relation between SBI dysfunctioning, local complications and the occurrence of general manifestations. Both the growing prevalence of SBI in French women (1,2% to date) and the typology of observed GS give to general practitioner a key place in SBI follow-up and early detection of their complications
Myofiber HLA-DR expression is a distinctive biomarker for antisynthetase-associated myopathy by Jessie Aouizerate( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

Necroptosis mediates myofibre death in dystrophin-deficient mice by Jennifer E Morgan( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

LE SYNDROME ANTI-HU OU ENCEPHALOMYELONEVRITE PARANEOPLASIQUE AVEC AUTO-ANTICORPS ANTINEURONAUX ANTI-HU : A PROPOS DE 7 OBSERVATIONS DE LA SALPETRIERE by FRANCOIS-JEROME AUTHIER( Book )

1 edition published in 1991 in French and held by 2 WorldCat member libraries worldwide

Mécanismes moléculaires impliqués dans la fusion des cellules précurseurs myogéniques humains by Peggy Lafuste( Book )

2 editions published in 2004 in French and held by 2 WorldCat member libraries worldwide

Cell therapy using transplantation of exogenous myogenic precursor cell (mpc) aimed at fusing with mature muscle fibres may help treating devastating muscle diseases. Characterization of molecular systems involved in mpc is a major goal to improve cell therapy. Fusion does not depend on the engagement of a single molecule, but rather on the coordinated recruitment of several molecules mediating ceIl aggregation, close cell-to-cell contact and, finally, the actual fusion event. Among the different human fusion systems, molecules from the ADAM family and the purinoceptor P2X7 could play a direct role in the cell fusion process itself. We showed in human mpc cultures, expression and partial functionality of P2X7. It seems to be implicated in cell death regulation during differentiation process more than in mpc fusion. We showed that human mpc constitutively express ADAMI2 and its integrin partner alpha9betal. Both molecuîes interact atcell-ceII contact areas. Inhibition strategies induce a significant decrease of fusion index. This effect is not due to ceIl de-adhesion from their support, and interaction of ADAM12 and alpha9betal s mainly operative in nascent myotube growth. We showed, in vivo, that in human the necrosislregeneration process is associated with high expression of both isoforms of ADAM1 2 (membrane-bound and secreted). Cells expressing ADAM12 are from myogenic, haematopoietic and interstitial origin. We believe that there is great interest in understanding mpc fusion, because of both ifs central role in muscle development and adult muscle repair, and the relevance of influencing muscle cell fusion for designing future therapeutic strategies
Myofascite à macrophages : étude clinique et paraclinique de 82 patients by Julien Champey( Book )

1 edition published in 2004 in French and held by 2 WorldCat member libraries worldwide

Interleukin-1 expression in normal motor endplates and muscle fibers showing neurogenic changes by François-Jérôme Authier( )

1 edition published in 1997 in English and held by 2 WorldCat member libraries worldwide

Rôle de l'endocytose et du compartiment endosomal dans la cytotoxicité de la toxine du choléra : implication de la cathepsine D by Clémence Merlen( Book )

2 editions published in 2007 in French and held by 2 WorldCat member libraries worldwide

Cholera toxin (CT) is produced by Vibrio cholerae and is the major virulence factor responsible for the massive secretory diarrhea of infected humans. CT is composed of one activating A subunit and five identical B subunits. The CTA subunit is comprised of two domains termed the A1 and A2 peptides. For full cytotoxicity, a production of A1 peptide must occur intracellularly. We demonstrated that proteolysis of cholera toxin within endosomes required an acidic pH and was sensitive to pepstatin A, an inhibitor of aspartic acid proteases. Hydrolysates of cholera toxin at acidic pH by cathepsin D displayed ADP-ribosyltransferase activity towards exogenous Gsa. Gsa and ARF proteins were immunodetected in rat liver endosomes prepared various times after toxin injection. Internalized CT displayed an ADP-ribosyltransferase activity towards endogenous Gsa protein. These data identify endosomal cathepsin D as a key enzyme responsible for cholera toxin cytotoxic activation
Publisher Correction: Necroptosis mediates myofibre death in dystrophin-deficient mice by Jennifer E Morgan( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Novel Missense CAPN3 Mutation Responsible for Adult-Onset Limb Girdle Muscular Dystrophy with Calves Hypertrophy by Sabrine Rekik( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Slow CCL2-dependent translocation of biopersistent particles from muscle to brain by Zakir Khan( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Modulations du métabolisme et de l'autophagie induites par l'exercice physique dans un modèle souris de sclérose latérale amyotrophique (SLA) by Céline Desseille( )

1 edition published in 2015 in French and held by 1 WorldCat member library worldwide

The use of physical exercise as an intervention for alleviating symptoms in Amyotrophic-Lateral-Sclerosis (ALS) is debated. We have reported that swimming based exercise sustained motor function, induced a significant neuroprotection and extended SOD1(G93A) ALS mouse lifespan in contrast to running based exercise. Because exercise types are expected to differentially alter, in trained skeletal muscles, the energy metabolism, whose defects have been very recently linked to ALS-induced motor-neuron death, we compared the impact of either a daily swimming- or running-based training on several metabolic indicators in ALS mice. We indicate that, unlike running, the swimming-based training of ALS mice led to a significant increase in lipogenesis and glucose tolerance, and reverse the metabolic switch affecting fast-twitch muscles. Besides, our data highlighted detrimental-side effects of the running-based training that further shifted the energetic status towards a more oxidative metabolism. Thus, the present data outline the paramount importance of the choice of the exercise type when designing rehabilitation protocols for ALS patients
Innovation physiothérapeutique dans l'amyotrophie spinale infantile : du modèle animal au patient by Farah Chali( )

1 edition published in 2014 in French and held by 1 WorldCat member library worldwide

Objective: Spinal Muscular Atrophy (SMA) is a group of autosomal recessive neurodegenerative diseases differing in their clinical outcome, characterized by the specific loss of spinal motor-neurons, caused by insufficient levels of SMN protein expression. No cure is presently available for SMA. While physical exercise might represent a promising approach for alleviating SMA symptoms, the lack of data dealing with the effects of different exercise types on diseased motor-units still precludes the use of exercise in SMA patients. Methods: We have evaluated the efficiency of two long-term physical exercise paradigms, either based on high intensity swimming or on low intensity running, in alleviating SMA symptoms in a mild type 3 SMA-like mouse model. Results: We found that a 10-month physical training induced significant benefits in terms of resistance to muscle damages, energetic metabolism, muscle fatigue and motor behavior. Both exercise types significantly enhanced motor-neuron survival, independently of SMN expression, leading to the maintenance of neuromuscular junctions and skeletal muscle phenotypes, particularly in the soleus, plantaris and tibialis of trained mice. Most importantly, both exercises significantly improved neuromuscular excitability properties. Besides, all these training-induced benefits are quantitatively and qualitatively related to the specific characteristics of each exercise, suggesting that the related neuroprotection is strongly dependent on the specific activation of some motor-neuron subpopulations. Interpretation: Taken together, the present data show significant long-term exercise benefits in a mild type 3 SMA context and provide important clues for designing rehabilitation programs in patients
Predictive value of brain 18F-FDG PET/CT in macrophagic myofasciitis?( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract: Rationale: Although several functional studies have demonstrated that positron emission tomography/computed tomography with 18 F-fluorodeoxyglucose (18 F-FDG PET/CT) appears to be efficient to identify a cerebral substrate in patients with known macrophagic myofasciitis (MMF), the predictive value of this imaging technique for MMF remains unclear. Patient concerns: We presented data and images of a 46-year-old woman. Diagnoses: The patient was referred to our center for suspected MMF due to diffuse arthromyalgias and cognitive disorder (involving an impairment of visual selective attention and a weakness in executive functions revealed by neuropsychological assessment) which occurred few years after last vaccine injections. Interventions: After a first negative deltoid muscle biopsy, a brain 18 F-FDG PET/CT was performed and revealed the known spatial pattern of a cerebral glucose hypometabolism involving occipital cortex, medial temporal areas, and cerebellum. Outcomes: Given the clinical suspicion of MMF and brain 18 F-FDG PET/CT findings, a 2nd deltoid muscle biopsy was performed and confirmed the diagnosis of MMF with typical histopathological features. Lessons: This case highlights the predictive value of brain 18 F-FDG PET/CT as a noninvasive imaging tool for MMF diagnosis, even when muscle biopsy result comes back negative
Muscle ischaemia associated with NXP2 autoantibodies: a severe subtype of juvenile dermatomyositis( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Mécanismes moléculaires impliqués dans la fusion des cellules précurseurs myogéniques humains by Peggy Lafuste( )

1 edition published in 2004 in French and held by 1 WorldCat member library worldwide

Les cellules musculaires striées squelettiques, sont des cellules multinucléées, formées par la prolifération, l'agrégation etla fusion de cellules précurseurs myogéniques (myogenic precursor cells, mpc) mononucléées. La caractérisation des mécanismes moléculaires impliqués dans le processus de fusion des cellules myogéniques humaines apparaît nécessaire à l'amélioration des biothérapies des maladies musculaires. Nous avons choisi d'évaluer in vitro l'implication de deux systèmes dans la fusion des mpc humaines l'ADAM12 et son partenaire intégrine alpha9betal et le récepteur purinergique P2X7. Nous avons montré l'expression du P2X7 par les mpc humaines et une partie de ses fonctions. Le récepteur P2X7 semble intervenir dan les mécanismes de régulation de la mort cellulaire plutôt que dans la fusion des mpc. Nous avons montré que les mpc humaines expriment constitutivement l'ADAM12 et l'intégrine alpha9betal in vitro et que les deux molécules interagissent entre elles aux zones de contact intercellulaire. L'inhibition du système ADAM12/ alpha9betal montre une diminution significative de l'index de fusion global. Cet effet n'est pas du à un détachement des mpc de leur support, et intervient principalement dans l'élongation des myotubes. Nous avons démontré in vivo chez l'homme une forte expression des 2 isoformes membranaire et secrétée d'ADAM 12 lors du processus de nécrose/régénération myocytaire; les cellules exprimant ADAM12 étant d'origine myogénique, hématopoïétique et interstitielle potentiellement myogénique. Le contrôle de la fusion des mpc avec les myocytes existants s'inscrit dans le développement de thérapies cellulaires efficaces des maladies musculaires
European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe by Luis Nacul( )

1 edition published in 2021 in English and held by 1 WorldCat member library worldwide

Designed by a group of ME/CFS researchers and health professionals, the European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) has received funding from the European Cooperation in Science and Technology (COST)-COST action 15111-from 2016 to 2020. The main goal of the Cost Action was to assess the existing knowledge and experience on health care delivery for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in European countries, and to enhance coordinated research and health care provision in this field. We report our findings and make recommendations for clinical diagnosis, health services and care for people with ME/CFS in Europe, as prepared by the group of clinicians and researchers from 22 countries and 55 European health professionals and researchers, who have been informed by people with ME/CFS
 
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Alternative Names
Authier FJ wetenschapper

Languages
French (13)

English (11)