WorldCat Identities

Zoeller, R. Thomas

Overview
Works: 21 works in 28 publications in 2 languages and 153 library holdings
Genres: Academic theses 
Roles: Contributor, Collector, Other, Author, Editor
Classifications: RC649, 616.4
Publication Timeline
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Most widely held works by R. Thomas Zoeller
Adverse Outcome Pathway on inhibition of Thyroperoxidase and subsequent adverse neurodevelopmental outcomes in mammals by Kevin M Crofton( )

4 editions published in 2019 in English and held by 51 WorldCat member libraries worldwide

Abstract: This AOP describes one adverse outcome that may result from the inhibition of thyroperoxidase (TPO) during mammalian development. Chemical inhibition of TPO results in decreased thyroid hormone (TH) synthesis, and subsequent reduction in circulating concentrations of THs. THs are essential for normal human brain development, both prenatally and postnatally, modulating genes critical for a normal neuroanatomical development, with subsequent effects on neurophysiology, and finally neurological function. Therefore, chemicals that interfere with TH synthesis have the potential to cause TH insufficiency that may result in adverse neurodevelopmental effects in offspring. Herein, we discuss the implications of developmental TPO inhibition for hippocampal anatomy, function, and ultimately neural function. The hippocampus is known to be critically involved in cognitive, emotional, and memory function. The adverse consequences of TH insufficiency depend both on severity and developmental timing, indicating that exposure to TPO inhibitors may produce different effects at different developmental windows of exposure
Perturbateurs endocriniens : où se trouvent-ils ? en quoi sont-ils dangereux ? comment s'en protéger ? by J.-P Bourguignon( )

2 editions published in 2021 in French and held by 43 WorldCat member libraries worldwide

Chaque jour, nous ingérons une importante quantité de produits chimiques. Invisibles, ils sont pourtant présents dans l'air, dans la nourriture, dans les boissons, dans les tissus... et tout ça sans que nous le sachions vraiment. Pourtant leur impact sur notre santé est loin d'être anodin : diminution des capacités cognitives, baisse de la fertilité, augmentation des maladies, troubles hormonaux... la liste est encore longue. Il est donc important de faire le point ! Pour conscientiser le lecteur sur sa consommation, le Dr Jean-Pierre Bourguignon a préparé un parcours participatif au cours duquel il pose des questions au lecteur pour ensuite y apporter des réponses claires visant à mieux comprendre ce dangereux fléau. Il y est ainsi question de la définition des perturbateurs endocriniens, de notre vulnérabilité à leur égard, de leurs effets sur la santé, etc. Il nous explique également comment les débusquer et les produits qu'il faut éviter
Les perturbateurs endocriniens : comment les cerner pour s'en protéger? by J.-P Bourguignon( Book )

2 editions published in 2019 in French and held by 15 WorldCat member libraries worldwide

Les perturbateurs endocriniens inquiètent, car ils sont nombreux et insaisissables. Leurs effets sur la santé sont, en outre, multiples. L'ambition de ce livre est de nous aider à saisir ces perturbateurs, c'est-à-dire à les repérer et à s'en prémunir. Où se trouvent-ils? En quoi sont-ils dangereux, et à quels moments de la vie particulièrement? Les auteurs, plutôt que d'apporter des réponses toutes faites, nous invitent à les construire avec eux. Le lecteur est ainsi sollicité tout au long de l'ouvrage pour atteindre les objectifs qui lui sont proposés chapitre par chapitre. Cet ouvrage s'adresse à nous, citoyens, qui faisons face à la présence de produits chimiques dans notre environnement. Peut-être sommes-nous juste curieux, avides de comprendre les défis qui en découlent afin de pouvoir les gérer. Mais peut-être aussi que nous souhaitons transmettre les informations que nous aurons recueillies à ce sujet, même si nous ne sommes pas des professionnels de la santé ou de l'éducation. Notre rôle de relai, nécessaire à la société, consiste alors à interpeller, à inviter tout un chacun à se poser les bonnes questions pour qu'ensemble, nous puissions y répondre de la meilleure façon possible. [Payot]
perturbateurs endocriniens : Où se trouvent-ils ? En quoi sont-ils dangereux ? Comment s'en protéger ? by Jean-Pierre Bourguignon( )

1 edition published in 2021 in French and held by 11 WorldCat member libraries worldwide

State of the science of endocrine disrupting chemicals - 2012 : an assessment of the state of the science of endocrine disruptors prepared by a group of experts for the United Nations Environment Programme (UNEP) and WHO( Book )

2 editions published in 2013 in English and held by 6 WorldCat member libraries worldwide

"This document provides the global status of scientific knowledge on exposure to and effects of endocrine disrupting chemicals (EDCs)." -- website
Science and policy on endocrine disrupters must not be mixed: a reply to a "common sense" intervention by toxicology journal editors by Åke Bergman( )

2 editions published in 2013 in English and held by 3 WorldCat member libraries worldwide

The "common sense" intervention by toxicology journal editors regarding proposed European Union endocrine disrupter regulations ignores scientific evidence and well-established principles of chemical risk assessment. In this commentary, endocrine disrupter experts express their concerns about a recently published, and is in our considered opinion inaccurate and factually incorrect, editorial that has appeared in several journals in toxicology. Some of the shortcomings of the editorial are discussed in detail. We call for a better founded scientific debate which may help to overcome a polarisation of views detrimental to reaching a consensus about scientific foundations for endocrine disrupter regulation in the EU
Assessing dose-response relationships for endocrine disrupting chemicals (EDCs): a focus on non-monotonicity by R. Thomas Zoeller( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Analyzing in situ gene expression in the mouse brain with image registration, feature extraction and block clustering by Manjunatha Jagalur( )

1 edition published in 2007 in English and held by 2 WorldCat member libraries worldwide

A path forward in the debate over health impacts of endocrine disrupting chemicals by R. Thomas Zoeller( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

PBDE flame retardants, thyroid disease, and menopausal status in U.S. women by Joseph G Allen( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women: a prospective cohort study by Mary V Díaz Santana( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement by Roland Langrock( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Parma consensus statement on metabolic disruptors by Jerrold J Heindel( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Correction to: Parma consensus statement on metabolic disruptors by Jerrold J Heindel( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Impacts of food contact chemicals on human health: a consensus statement by Jane Muncke( )

1 edition published in 2020 in English and held by 2 WorldCat member libraries worldwide

Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project by A Kortenkamp( )

1 edition published in 2020 in English and held by 1 WorldCat member library worldwide

The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no internationally validated in vitro assays, and test methods that can capture the consequences of diminished or enhanced thyroid hormone action on the developing brain are missing entirely. These gaps put the public at risk and risk assessors in a difficult position. Decisions about the status of chemicals as thyroid hormone system disruptors currently are based on inadequate toxicity data. The ATHENA project (Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies) has been conceived to address these gaps. The project will develop new test methods for the disruption of thyroid hormone transport across biological barriers such as the blood-brain and blood-placenta barriers. It will also devise methods for the disruption of the downstream effects on the brain. ATHENA will deliver a testing strategy based on those elements of the thyroid hormone system that, when disrupted, could have the greatest impact on diminished or enhanced thyroid hormone action and therefore should be targeted through effective testing. To further enhance the impact of the ATHENA test method developments, the project will develop concepts for better international collaboration and development in the area of thyroid hormone system disruptor identification and regulation
Alterations to maternal behavior and brain by exogenous estrogen exposure by Mary Catanese( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Maternal care is critical for the development and long-term success of offspring. Poor maternal care can have profound effects on offspring that can last into adult life. Despite our understanding of the role of endogenous estrogen in maternal behavior, the potential effects of exogenous estrogens (xenoestrogens) on maternal behavior and brain remain poorly understood. The active synthetic estrogen in contraceptive pills, 17[alpha]-ethinyl estradiol (EE2), is widely used as a positive control for estrogenicity in endocrinology and toxicology studies. Another xenoestrogen, bisphenol A (BPA) alters a broad range of physiological processes including neural development and reproduction. Due to public health concerns with BPA, alternative compounds have been developed for use in consumer products. One replacement, bisphenol S (BPS), has not been examined extensively, but has shown estrogenic properties. Biomonitoring studies indicate that human exposures to BPS are likely to be widespread. Among studies that have reported effects of endocrine disruptors on maternal behavior, none have concurrently examined effects on the regions of the brain important to maternal behaviors. Thus, one of the major goals of this dissertation sought to address this gap in current knowledge. We hypothesized that low doses of two xenoestrogens, EE2 and BPS, would disrupt maternal behavior and affect regions of the brain important for maternal behavior. We further hypothesized that neurogenesis might be one of the critical mechanisms underlying estrogen regulated maternal behavior and that xenoestrogen exposures during pregnancy induce alterations to neurogenesis. We investigated the effects of low dose exogenous estrogens on mice during pregnancy and lactation (the F0 generation), and on females exposed during gestation and the perinatal period (the F1 generation). The work summarized in this dissertation indicates that low doses of the synthetic estrogens EE2 and BPS alter aspects of behavior and brain in pregnant/lactating females, providing evidence that adults are susceptible to the disruptive effects of these compounds during these vulnerable periods. Our findings also suggest that females are vulnerable to exposures during gestation/perinatal development, and these exposures are sufficient to influence the display of maternal behavior later in life. Finally, our results indicate that neurogenesis can be disrupted by xenoestrogen exposures
Les perturbateurs endocriniens : comment les cerner pour s'en protéger ? by J.-P Bourguignon( Book )

1 edition published in 2019 in French and held by 1 WorldCat member library worldwide

Les hormones intriguent, voire elles inquiètent. Que dire alors des perturbateurs endocriniens ? Ils font peur car ils sont nombreux et insaisissables, et leurs effets sur la santé sont, en outre, multiples.L'ambition de ce livre est de vous aider à saisir ces produits chimiques, c'est-à-dire à les comprendre et à s'en prémunir. Où se trouvent-ils ? En quoi sont-ils dangereux, et à quels moments de la vie particulièrement ? Les auteurs, plutôt que d'apporter des réponses toutes faites, vous invitent à les construire avec eux. Chacun est sollicité tout au long de l'ouvrage pour progresser dans sa réflexion à travers les questions et objectifs qui sont envisagés, chapitre par chapitre.Sans être un professionnel de la santé ou de l'éducation, vous pourrez bientôt vous aussi partager avec d'autres votre savoir et inciter votre entourage aux bons réflexes dans l'univers des perturbateurs endocriniens.Anne-Simone Parent, Docteure en médecine et en sciences biomédicales et pédiatre endocrinologue, poursuit les recherches du Dr Bourguignon sur le mécanisme du déclenchement de la puberté dans le cerveau et ses perturbations par l'environnement.R. Thomas Zoeller, professeur de biologie à l'Université de Massachusetts, étudie notamment l'action de l'hormone thyroïdienne sur le développement du cerveau, et la façon dont l'environnement peut venir perturber cette action
Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society by R Thomas Zoeller( )

1 edition published in 2012 in Undetermined and held by 1 WorldCat member library worldwide

An endocrine-disrupting chemical (EDC) is an exogenous chemical, or mixture of chemicals, that can interfere with any aspect of hormone action. The potential for deleterious effects of EDC must be considered relative to the regulation of hormone synthesis, secretion, and actions and the variability in regulation of these events across the life cycle. The developmental age at which EDC exposures occur is a critical consideration in understanding their effects. Because endocrine systems exhibit tissue-, cell-, and receptor-specific actions during the life cycle, EDC can produce complex, mosaic effects. This complexity causes difficulty when a static approach to toxicity through endocrine mechanisms driven by rigid guidelines is used to identify EDC and manage risk to human and wildlife populations. We propose that principles taken from fundamental endocrinology be employed to identify EDC and manage their risk to exposed populations. We emphasize the importance of developmental stage and, in particular, the realization that exposure to a presumptive "safe" dose of chemical may impact a life stage when there is normally no endogenous hormone exposure, thereby underscoring the potential for very low-dose EDC exposures to have potent and irreversible effects. Finally, with regard to the current program designed to detect putative EDC, namely, the Endocrine Disruptor Screening Program, we offer recommendations for strengthening this program through the incorporation of basic endocrine principles to promote further understanding of complex EDC effects, especially due to developmental exposures
 
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Languages
English (20)

French (6)