WorldCat Identities

Guignant, Caroline

Overview
Works: 6 works in 7 publications in 2 languages and 11 library holdings
Roles: Author, Contributor, Other
Publication Timeline
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Most widely held works by Caroline Guignant
Upregulation of the pro-apoptotic genes BID and FAS in septic shock patients by Fanny Turrel-Davin( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Th17 and CD24hiCD27+ regulatory B lymphocytes are biomarkers of response to biologics in rheumatoid arthritis by Sarah Salomon( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Evaluation de quatre précurseurs d'hormones vasoactives comme marqueurs prédictifs de la mortalité au cours du choc septique by Caroline Guignant( Book )

2 editions published between 2011 and 2012 in French and held by 2 WorldCat member libraries worldwide

Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients by Caroline Guignant( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major trauma by Aurélie Cheron( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Biomarqueurs des états septiques sévères : vers de nouvelles stratégies thérapeutiques individualisées by Caroline Guignant( )

1 edition published in 2011 in French and held by 1 WorldCat member library worldwide

Septic syndromes remain the leading cause of death in the intensive care units despite numerous clinical trials. Septic patients constitute a very heterogeneous population. Therefore improved characterisation of patients in order to better target and personalize potential new therapeutics is highly desirable. A multiparametric biomarker-based approach could be an attractive alternative to obtain a global view of the pathophysiologic situation. In this context, we worked specifically on cardio-vascular and immune dysfunctions. We first confirmed the predictive value of biomarkers for mortality or nosocomial infections, and showed new elements. We observed that (1) PD-1 overexpression is associated with leukocyte anergy, (2) one biomarker could give different information over time, (3) information provided by the association of two biomarkers is more interesting than the addition of their individual values, and (4) dynamic expression of one biomarker is more informative than its expression at a given time point. Finally, our results illustrate the potential interest of biomarker panels to improve our understanding of the septic syndrome complexity and to reflect their rapid evolution. Consequently, next step will depend on our capacity to develop biostatistic tools that enable clinicians to get, in real time, a global view of the process over time. This key step is likely necessary to decrease the heterogeneity of septic patient population in order to better stratify and target next clinical trials in the field
 
Audience Level
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Audience Level
1
  Kids General Special  
Audience level: 0.96 (from 0.95 for Evaluation ... to 0.97 for Programmed ...)

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