WorldCat Identities

Djaker-Oudjhara, Nadia (1978-....).

Works: 8 works in 12 publications in 2 languages and 14 library holdings
Roles: Opponent, Author
Publication Timeline
Most widely held works by Nadia Djaker-Oudjhara
Microscopie par diffusion cohérente Raman CARS : application à l'imagerie des milieux biologiques by Nadia Djaker-Oudjhara( Book )

4 editions published between 2006 and 2011 in French and held by 4 WorldCat member libraries worldwide

La microscopie par diffusion Raman Cohérente Anti-Stokes (CARS) est une méthode récente d'imagerie dont le contraste provient des vibrations moléculaires intrinsèques d'une liaison ou d'un ensemble de liaisons chimiques. Cette technique présente l'avantage de s'affranchir de tout marqueur fluorescent qui peut être toxique pour un organisme biologique vivant. Elle permet aussi d'avoir une très grande sensibilité et une forte resolution spatiale, comparable à celle de la microscopie confocale. Le travail de cette thèse, concerne la réalisation d'un microscope CARS, et sa mise en application à différents domaine de l'imagerie bio-médicale. Des études ont été menées démontrant les potentialités de cet outil, ainsi que sa caractérisation dans le domaine spatiale et spectral
Study of Toxicity of Nanoparticles in Biological Media by Sadequa Sultana( Book )

2 editions published in 2015 in English and held by 3 WorldCat member libraries worldwide

Gold nanoparticules (GNPs) are of great interest for several applications in nanomedicine ; espacially in imaging and sensing, drug delivery or photothermal therapy because of their unique physical and chemical properties. For all theses applications, a better understanding of the interaction of GNPs with biomolecules and their uptake into cells is of great importance. Thus the main objective of this thesis was to study the toxicity of GNPs in biological media based on their sizes, shapes and surface chemistries. Cytotoxicity studies on human cells were done in vitro in presence of six GNP samples having spherical and flower shapes. We compared the cytotoxic effects and showed that it was largely higher for flower-shaped GNPs than spherical ones. Further we built-up the optical assembly and the set-up of the Fluorescence Correlation Spectroscopy (FCS). Followed by the set-up, the sensitivity, the resolution and other parameters were determined during the characterization of the FCS sytem. Then FCS was used to characterize fluorescent molecule-conjugated GNP, wich were fabricated in the interest of biomedical applications. In the next step, we characterized the diffusion behavior of MitoTracker dye labeled mitochondria by FCS in order to be able to compare in future the mitochondrial diffusion after incubating with GNPs, wich is described as the perspectives
Influence of the Aptamer Grafting on its Conformation and its Interaction with Targeted Protein by Celia Arib( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Etude de l'effet plasmonique des nanoparticules métalliques aléatoires sur les performances des diodes électroluminescences organiques. by Amadou thierno Diallo( )

1 edition published in 2018 in French and held by 1 WorldCat member library worldwide

This thesis focuses on the utilization of localized surface plasmon resonances (LSPR) of metallic nanoparticles (NPs) to improve the performance of Organic Light Emitting Diodes (OLEDs). In particular, we focused on randomly dispersed NPs by thermal evaporation during the OLED fabrication process. In the first part of the experimental work, we focused on the fabrication and study of random NPs of silver. The effects of their position with respect to the emissive layer (EML) were studied. The results show improvements in electrical and optical performance of OLEDs incorporating these NPs for EML-NPs distances greater than 15 nm. Subsequently, we were interested in the study of the plasmonic field range action by developing an original method based on the use of a DCM red-emitting layer embedded in Alq3 green EML. By varying the position of this thin layer of DCM, it was possible to probe at the nanoscale the extent of the effects of Au NPs in particular on the variation of the luminous efficiency of the OLED. Finally, we studied the influence of Al plasmonic nanoparticles (NPs) on the performance of a blue OLED subjected to the emission of exciplexes. The results show that in the case of OLED with Al-NPs, the emission of exciplexes is reduced thanks to the LSPR effect and the luminous efficiency of the plasmonic device indicates a 53% improvement over that of the OLED without NPs
Développement de nanovecteurs à base de nanoparticules d'or : Applications biomédicales by Hanane Moustaoui( )

1 edition published in 2018 in French and held by 1 WorldCat member library worldwide

The fight against cancer is a major challenge for public health, since cancer remains the leading cause of death in France. Conventional treatment like chemotherapy use very toxic products that induce large side effects. In this context, Gold nanoparticles (GNP) are of great interest thanks to their unique physical and chemical properties and are considered as promising agents for cancer therapy as drug delivery or photothermal agents. The aim of this thesis is to develop and study GNP and their interaction with biomolecules (proteins) in the framework of the cancer treatment. Firstly, two PEGyled GNP were synthetized and used as platform to develop nanovectors for doxorubicin ((DOX) anticancer drug), following two different strategies. The first strategy consists in synthesizing PEGyled GNP following “one-step” approach. Then the DOX loading on the nanoparticles was carried out by carbodiimide chemistry. The second strategy was performed by complexing DOX with gold ions, protected by PEG to form clusters. Afterwards these clusters are reduced to synthetize the GNP. The Physicochemical properties of these two kinds of GNP were characterised by TEM, optical absorption and Raman spectroscopy. Finally a cell viability study was carried out to compare the cytotoxicity effects of these two nanovectors on one pancreatic cancer cell line, PANC-1. In the second part, we studied the adsorption of three proteins of human blood serum (albumin, lysosime and glycoprotein) on citrate capped GNP. For this task, we have chosen to use scattering correlation spectroscopy as a tool to quantify the increase of the GNP hydrodynamic radius induced by the protein adsorption. The results showed that each protein has a specific orientation but also different binding affinity and cooperativity with the GNP surface. Finally, in the last part, we investigated the photothermal properties of citrate capped GNP of different sizes and shapes. The results show that the temperature rise depends on the plasmon resonance position compared to the excitation wavelength but also on the shape and the surface chemistry. This work was done to understand how photothermal effect produced by GNP can destroy cancer cells
Comparative toxicity evaluation of flower-shaped and spherical gold nanoparticles on human endothelial cells( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Abstract: In this paper, we propose a multi-parametric in vitro study of the cytotoxicity of gold nanoparticles (GNPs) on human endothelial cell (HUVEC). The cytotoxicity is evaluated by incubating cells with six different GNP types which have two different morphologies: spherical and flower-shaped, two sizes (∼15 and ∼50 nm diameter) and two surface chemistries (as prepared form and PEGylated form). Our results showed that by increasing the concentration of GNPs the cell viability decreases with a toxic concentration threshold of 10 pM for spherical GNPs and of 1 pM for flower-shaped GNPs. Dark field images, flow cytometry and spreading test revealed that flower-shaped GNPs have more deleterious effects on the cell mechanisms than spherical GNPs. We demonstrated that the main parameter in the evaluation of the GNPs toxicity is the GNPs roughness and that this effect is independent on the surface chemistry. We assume that this behavior is highly related to the efficiency of the GNPs internalization within the cells and that this effect is enhanced due to the specific geometry of the flower-shaped GNPs
Biodétection d'analytes de faible taille par l'intermédiaire de nanostructures résonantes by Méderic Lequeux( )

1 edition published in 2019 in French and held by 1 WorldCat member library worldwide

This project is based on ANR project named Nanobiosensor, have for goal to make a QCM/SERS biosensor to sense small analytes. Development of transducer with nanostructures allow to obtain a better reproducibility and measurement reliability. Gold nanostructures allow me to acquire SERS measurement of molecule on the surface and identify it. Moreover, the nanostructures on quartz ship allow me to quantify how many molecules I have on the surface. The coupling of QCM/SERS allow me the access of identification, quantity and observation of small analyte. This coupling has two main goal, the first is to improve the understanding of molecular interaction between streptomycin and the bioreceptor. And the second, the coupling of these two methods allow to develop a sensor to detect small analytes
Détection de molécules biologiques par méthodes optiques by Qiqian Liu( )

1 edition published in 2021 in French and held by 1 WorldCat member library worldwide

Une nouvelle nanoparticule hybride offrant une bonne stabilité et pouvant être utilisée dans plusieurs applications biomédicales et fournissant une détection très sensible de biomarqueurs et des effets thérapeutiques élevés pour cibler spécifiquement les cellules cancéreuses. Pour ce faire, j'ai utilisé une nouvelle méthode de synthèse exploitant la complexation des sels d'or. Cette méthode permet non seulement le greffage de récepteurs spécifiques à la surface des nanoparticules mais également introduire d'agents thérapeutiques pour le cancer. Cette particule spécifique a été testée dans un premier temps pour la détection de la protéine Galectine-1 ( un biomarqueur du cancer) et du glucose ainsi que pour le traitement du cancer du foie chez la souris. une étude sur le comportement des nanoparticules d'or lorsqu'elles interagissent avec une protéine spécifique à l'aide de méthodes spectroscopiques
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Microscopie par diffusion cohérente Raman CARS : application à l'imagerie des milieux biologiques
Alternative Names
Djaker, Nadia

Nadia Djaker onderzoeker