Jégot, Gwenhael

Factors acting on Mos1 transposition efficiency by Ludivine Sinzelle( )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

Exogenous mRNA delivery and bioavailability in gene transfer mediated by piggyBac transposition by Solenne Bire( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Mise au point d'un système dérivé du transposon Mos1 comme vecteur non viral de transfert de gène en cellules eucaryotes by Gwenhael Jegot( Book )

2 editions published in 2007 in French and held by 2 WorldCat member libraries worldwide

The mariner Mos 1 transposon can naturally move into the genome. The first research axis of this work concern the transposon characteristics which act upon the transposition activity of Mos1 (like the nucleic content of the transposon and its size). It have shown that a size of transgene upper than 2,5 kb limit the transposition efficiency, that a strong GC percentage favour the transposition, and that there is no minimal size for Mos1 transposition. The second research axis concern the adaptation and improvement of the Mos1 system to the eukaryotic cells, to developp a nonviral vector for gene transfer. The addition of a nuclear localization sequence improve the nuclear transfer, the "humanization" of the transposase sequence increase it expression in mammal cells, and the use of the HSVtK suicide system permit to limit the recombination events

Low reversibility of intracellular cAMP accumulation in mouse Leydig tumor cells (MLTC-1) stimulated by human Luteinizing Hormone (hLH) and Chorionic Gonadotropin (hCG)( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Profiling of FSHR negative allosteric modulators on LH/CGR reveals biased antagonism with implications in steroidogenesis( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide