Henni-Silhadi, Widad (1975-....).

Comportement interfacial et en solution de polysaccharides amphiphiles : application à la solubilisation de principes actifs hydrophobes by Widad Henni-Silhadi( Book )

2 editions published in 2007 in French and held by 3 WorldCat member libraries worldwide

This manuscript focuses on the comparative study of physico-chemical properties of amphiphilic carboxymethylpullulans differing by the length and the percentage of grafted alkyl chains , and on their application to the solubilisation of hydrophobic drugs. In aqueous solutions, hydrophobic interactions induce the formation aggregates. The polarity of the aggregates core depends on polymers composition and external factors. The surface tension studies evidenced a difference between the interfacial properties of polymers containing more than 10% of octyl chains and those substituted with long alkyl chains. The solubility studies showed that the polymer with the higher percentage of alkyl chains was the most effective in solubilizing benzophenone and docetaxel. In vitro, the polymer-docetaxel formulation was equipotent against cancer cells to the commercial docetaxel one. Furthermore, the polymer appeared less cytotoxic against macrophages than the excipient used in the commercial form

Enhancement of the Solubility and Efficacy of Poorly Water-Soluble Drugs by Hydrophobically-Modified Polysaccharide Derivatives by Widad Henni-Silhadi( )

1 edition published in 2007 in English and held by 2 WorldCat member libraries worldwide

Influence of alkyl chains length on the conformation and solubilization properties of amphiphilic carboxymethylpullulans by Widad Henni-Silhadi( )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

Les plans de gestion des risques appliqués aux vaccins by Widad Henni-Silhadi( )

1 edition published in 2017 in French and held by 1 WorldCat member library worldwide