WorldCat Identities

Bezanahary, Holy (1974-....).

Overview
Works: 9 works in 10 publications in 2 languages and 13 library holdings
Genres: Handbooks and manuals 
Roles: Thesis advisor, Author
Classifications: RC900.9, 616.047
Publication Timeline
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Most widely held works by Holy Bezanahary
Comparaison des caractéristiques cliniques, biologiques et évolutives de patients atteints d'un syndrome des antiphospholipides primaire, en fonction du genre by Magalie Rolland( )

2 editions published in 2020 in French and held by 3 WorldCat member libraries worldwide

Introduction : Antiphospholipid Syndrome (APS) is a rare autoimmune disease characterized by an acquired thrombophilic disorder linked to the lasting presence of antiphospholipid antibodies. It manifests mainly by the occurrence of obstetric comorbidities as well as arterial or venous thromboses. The study of APS aims among other to explore the different symptoms between men and women. Objective: to compare the characteristics and risk factors of thrombosis according to gender, in patients with primary APS. Material and method: A cohort study of patients meeting the classification criteria of the APS taking place from January 1999 to October 2016 in the internal medicine department of the Limoges University Hospital. Sociodemographic, clinical, and biological data were collected retrospectively. Results: 32 patients with a total of 46 thrombotic events were included. The average age at diagnosis was 47.3 years. Data of fourteen different risk factors for thrombosis was collected. There was no significant difference between genders regarding the incidence and location of thrombotic events. Men and women had the same risk profile for thrombosis. The average body mass index reflected an overweight population, and was significantly stable during follow-up, in both women and men. Conclusion: we found no significant differences in the risk profile of primary APS and thrombosis between women and men. We suggest further research comparing the manifestations of APS and associated comorbidities according to gender, in order to improve the quality of care
Grossesse et auto-immunité : expérience monocentrique de 2002 à 2012, intérêt d'une prise en charge multidisciplianire by François-Xavier Lapebie( Book )

1 edition published in 2013 in French and held by 2 WorldCat member libraries worldwide

Systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS) and Hashimoto's thyroiditis are the most common auto-immune disorders to deal with during pregnancy. They may cause pregnancy losses, fetal and maternal morbidities. Pregnancy can induce flares of auto-immune diseases. The presence of antiphospholipid antibodies during pregnancy without definite APS is common and there is a relationship with obstetrical complications. The management of these patients is difficult and consensus in treatment strategy is currently lacking. A multidisciplinary approach is probably necessary. We conducted a monocentric retrospective study of 165 pregnancies in 109 women, between 2002 and 2012, followed up by a multidisciplinary team with internists, obstetricians and anesthesists: 14.5% of pregnancies were associated with APS, 50.9% with aPL but no definite APS, 33.3% with SLE and 24.2% with dysthyroidia and/or anti-TPO antibodies. A previous history of obstetrical complications were found up to 75.8% of pregnancies. Fourty-three percent of pregnancies received low-dose aspirin (LDA), 35.2% LDA plus thromboprophylactic dose of low-molecular-weight heparin (LMWH), 10.9% received LDA plus curative anticoagulation dose of LMWH, 38.3% were on hydroxychloroquine and 43.8% received low prednisone dose. The live birth rate was 89.1%. Obstetrical complications occurred in 80.6% of pregnancies. Our cases serie highlight the importance of a multidisciplinary care for these pregnancies
La vaccination des patients adultes ayant une maladie auto-immune systémique en médecine générale by Joseph Denizot( Book )

1 edition published in 2013 in French and held by 2 WorldCat member libraries worldwide

Objective: evaluating the generalist's vaccinal practice in their adults patients with autoimmune disease. Method: it's a practice evaluation. A test has been send to 200 generalists randomed selected among 427 Haute-Vienne practicians. Tests were send in may 2012. Results: 98 tests had been return. The response rate was 49%. 87% of practicians vaccine themselves patients without immunosuppressive treatment. When patients have immunosuppressive treatment 43% seek advice to a specialist before vaccination. Only 38,9% know that no vaccine is not-indicated in patients without immunosuppressive treatment. 5,2% think that no vaccine is not-indicated in patients with immunosuppressive therapy. Only one practician has made a pharmaco-vigilance declaration on a possible multiple sclerosis thrust after vaccination against hepatitis B. No doctor has occurred in case of disease vaccine. Only 4,1% have reported side effects. 88% of doctors do not meter protective serum antibodies after vaccination. 81% of doctors do not find themselves sufficiently informed on this subject. Half of them require updating their knowledge through medical education. Conclusion: to improve immunization coverage of patients with autoimmune disease, doctors better information is needed
La maladie lupique et la grossesse : étude prospective de 40 grossesses chez 23 patientes by Holy Bezanahary( Book )

1 edition published in 2002 in French and held by 2 WorldCat member libraries worldwide

La sprue tropicale : à propos d'un cas et revue de la littérature by François Maisongrande( Book )

1 edition published in 2008 in French and held by 1 WorldCat member library worldwide

La sprue tropicale est une affection connue depuis la seconde moitié du 18e siècle. Elle touche l'intestin grêle et se manifeste initialement par une gastroentérite aiguë. En phase d'état, une diarrhée chronique est associée à un syndrome de malabsorption sévère avec un amaigrissement important pouvant aboutir à une cachexie. Biologiquement, une anémie macrocytaire par carence en folates et/ou en vitamine B12 est quasiment constante. Histologiquement, on retrouve classiquement sur les biopsies intestinales une atrophie villositaire, un infiltrat inflammatoire du chorion et de l'épithélium et des gouttelettes lipidiques sous la couche entérocytaire. La sprue tropicale est endémique dans des zones tropicales précises : Inde, Asie du Sud-Est, Caraïbes. Elle peut toucher les autochtones, les expatriés vivant dans ces régions et les voyageurs. Elle est rare sous nos climats tempérés. Nous avons recensé seulement 16 cas français dans la littérature depuis 1946. Son étiologie reste inconnue bien qu'une cause infectieuse bactérienne soit fortement suspectée. Son diagnostic est d'élimination. Son traitement associe une antibiothérapie (tétracyclines) et une vitaminothérapie (acide folique +/- vitamine B12). Son pronostic est le plus souvent favorable, surtout chez les voyageurs. Nous rapportons le cas d'un patient de 48 ans victime d'une sprue tropicale de révélation tardive, 8 ans après un séjour prolongé à Haïti. Le diagnostic différentiel avec une maladie cœliaque peut être difficile en climat tempéré. Un test thérapeutique simple à l'aide d'une antibiothérapie, comme dans notre cas, peut alors venir confirmer le diagnostic de sprue tropicale
Steroid-sparing effect and toxicity of dapsone treatment in giant cell arteritis( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract : Abstract: Although a glucocorticoid (GC)-sparing strategy is needed for patients with giant cell arteritis (GCA) suffering from refractory disease or serious treatment-related complications, evidence of efficacy in this setting of immunosuppressive drugs and biotherapies is lacking. Herein, we evaluated the GC-sparing effects and tolerability of addition of dapsone (DDS) to prednisone therapy in patients with GCA. We retrospectively assessed data on 18 GCA patients who received DDS as a first-line treatment (DDS-1 group) and 52 patients who received it as a second- or third-line treatment for refractory GCA, with or without excessive GC-related toxicity (DDS-2 group). Of these 70 patients, 63 belonged to an inception cohort of 478 patients, whereas the remaining 7 were referred to our department for resistant GCA. In all, 52 patients were assessable for DDS efficacy. The baseline characteristics of the DDS-1 patients were similar to those of 395 GCA patients (control group) who received prednisone alone. DDS-1 patients had a more sustained decrease in GC dose with a lower mean prednisone dose at 12 months, and they comprised higher proportions who achieved GC withdrawal within the first year, who stopped prednisone treatment, and who recovered from GCA (P <0.001 for each variable). Patients in the DDS-2 group achieved a mean rate of prednisone reduction of 65% and a prednisone dose reduction of 16.9 ± 13.3 mg/d. The monthly decreases in the prednisone dose were 2.4 and 1.25 mg in DDS-1 and DDS-2 patients, respectively. DDS-induced side effects were recorded in 44 (64%) assessable patients. These side effects led to lowering of the DDS dose by 25 mg/d in 11 (16%) patients and permanent cessation of DDS in 14 patients (20%), due to allergic skin rash in 7, agranulocytosis in 2, icteric hepatitis in 2, and excessive hemolysis in 2 patients. DDS is a potent GC-sparing agent in GCA that should be evaluated in prospective studies. However, DDS use should be restricted to refractory GCA patients due to its toxicity, and close clinical and laboratory monitoring for 3 months is necessary
120 diagnostics à ne pas manquer by Élisabeth Vidal-Cathala( Book )

1 edition published in 2011 in English and held by 1 WorldCat member library worldwide

Si l'erreur de diagnostic n'est pas une faute pénale en soi, les conditions dans lesquelles le médecin a été conduit à faire cette erreur, peuvent par contre être retenues comme constitutives de fautes. La tendance actuelle à la judiciarisation de la relation médecin-malade et la surcharge de travail obligent encore davantage tous les praticiens à optimiser la prise en charge d'un patient, qui commence évidemment par un diagnostic juste. Ce diagnostic se doit donc d'être précis et rapide et s'appuie sur des signes cliniques ou des symptômes évoqués par le patient. Il repose
Influence des groupes sanguins ABO sur la survenue de la pré-éclampsie by Jonathan Thiolon( )

1 edition published in 2018 in French and held by 1 WorldCat member library worldwide

Objective: To evaluate the influence of the blood group ABO phenotype on the occurrence of pre-eclampsia. Methods: We performed a retrospective case-control study over an 8-year period. Data from our study population are extracted from a registry that included prospectively all pregnancies followed at the Limoges mother and child hospital. The women were divided into two groups according to the presence or absence of placental vascular complications. An individual match of two controls for one case was performed based on age, parity, body mass index and year of delivery. The prevalence of different blood groups was related to the occurrence of placental vascular complication. Results: The study population consisted of 789 women, included 263 cases and 526 controls. No significant difference was observed between women with pre-eclampsia and controls for non-O groups combined (58% versus 61.9%, p = 0.314), group A (40.3% versus 43.7%, p = 0.387), group B (13.7% versus 14.8%, p = 0.675) and the AB group (4% versus 3.4%, p = 0.688). There was also no difference between all of our cases and the group of controls for non-O groups combined (58% versus 62%, p = 0.282), group A (40.3% versus 43.3%, p = 0.413), group B (13.7% versus 15.2%, p = 0.564) and the AB group (4% versus 3.4%, p = 0.693). Conclusions: There is no influence of the ABO phenotype on the occurrence of pre-eclampsia
Grossesse et auto-immunité expérience monocentrique de 2002 à 2012, intérêt d'une prise en charge multidisciplianire by François-Xavier Lapebie( )

1 edition published in 2013 in French and held by 0 WorldCat member libraries worldwide

Systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS) and Hashimoto's thyroiditis are the most common auto-immune disorders to deal with during pregnancy. They may cause pregnancy losses, fetal and maternal morbidities. Pregnancy can induce flares of auto-immune diseases. The presence of antiphospholipid antibodies during pregnancy without definite APS is common and there is a relationship with obstetrical complications. The management of these patients is difficult and consensus in treatment strategy is currently lacking. A multidisciplinary approach is probably necessary. We conducted a monocentric retrospective study of 165 pregnancies in 109 women, between 2002 and 2012, followed up by a multidisciplinary team with internists, obstetricians and anesthesists: 14.5% of pregnancies were associated with APS, 50.9% with aPL but no definite APS, 33.3% with SLE and 24.2% with dysthyroidia and/or anti-TPO antibodies. A previous history of obstetrical complications were found up to 75.8% of pregnancies. Fourty-three percent of pregnancies received low-dose aspirin (LDA), 35.2% LDA plus thromboprophylactic dose of low-molecular-weight heparin (LMWH), 10.9% received LDA plus curative anticoagulation dose of LMWH, 38.3% were on hydroxychloroquine and 43.8% received low prednisone dose. The live birth rate was 89.1%. Obstetrical complications occurred in 80.6% of pregnancies. Our cases serie highlight the importance of a multidisciplinary care for these pregnancies
 
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120 diagnostics à ne pas manquer
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