WorldCat Identities

Makky, Ali (1982-....).

Works: 3 works in 4 publications in 1 language and 6 library holdings
Roles: Author, Contributor, Opponent, Thesis advisor
Publication Timeline
Most widely held works by Ali Makky
Analyse des mécanismes de pénétration intramembranaire de porphyrines glycoconjuguées utilisables en thérapie photodynamique des cancers : modélisation des interactions spécifiques et non-spécifiques by Ali Makky( Book )

2 editions published in 2010 in English and held by 3 WorldCat member libraries worldwide

La complexité des membranes biologiques est à l'origine du développement des modèles membranaires artificiels comme outils indispensables à la compréhension des mécanismes d'interaction entre médicaments et membrane cellulaire. Cette thèse porte sur l'étude des interactions non spécifiques et spécifiques entre de nouvelles porphyrines glycoconjuguées utilisables en thérapie photodynamique (PDT) et des modèles membranaires biomimétiques (monocouches, bicouches planes supportées et liposomes) du rétinoblastome portant à leur surface une lectine spécifique du mannose. Les principales techniques utilisées pour cette étude sont la tensiométrie de surface, la spectrométrie de fluorescence, la microbalance à cristal de quartz avec mesure de dissipation (QCM-D) et diffusion quasi-élastique de lumière (DLS). Les porphyrines glycoconjuguées se sont avérées comme des molécules prometteuses, capables à interagir d'une manière non spécifique (pénétration passive) et spécifique (ciblage des récepteurs de type lectinique) avec les modèles membranaires du rétinoblastome
Multimodal Dispersion of Nanoparticles: A Comprehensive Evaluation of Size Distribution with 9 Size Measurement Methods by Fanny Varenne( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Conception de nanomédicaments photostimulables à base de lipides et porphyrines ou de conjugués lipide-porphyrine pour la libération contrôlée de substances actives by Julien Massiot( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

The aim of this work was to develop an innovative stimulus-responsive delivery system. Based on lipid vesicles, it allows the controlled release, by light, of a hydrophilic anti-cancer substance encapsulated in their aqueous core. Once illuminated, porphyrin molecules inserted into the lipidic bilayer, generate singlet oxygen which oxidizes the unsaturated acyl chains of the phospholipids. This induces an increase in the permeability of the liposomes and the release of their cargo. We first made a selection of phospholipids and porphyrins to build the system. Our experimental study could be correlated with results of molecular dynamics simulations. The whole work highlighted the importance of the depth of insertion of porphyrin into the lipid bilayer and its proximity to the double bond of phospholipids. But it also showed the limits of this system. We then developed two new molecules, derived from natural phospholipids, to which pheophorbide a was coupled. The conjugates were able to form self-assembled vesicles but were unstable and quickly aggregated. We therefore associated these conjugates with classical lipids (DSPC, cholesterol) and analyzed the properties of these mixtures. We highlighted photothermal properties of the designed systems, capable of inducing a temperature rise of 14 °C. The generation of heat, responsible for a greater fluidity of the lipid bilayer, subsequently promoted the encapsulated cargo release. Finally, the two synthesized conjugates showed a phototoxic activity (PDT), with selectivity towards esophageal cancer cells. These new molecules therefore offer many opportunities for the development of multimodal, bio-inspired and biodegradable systems, for the delivery of a drug under the effect of light
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Alternative Names
Ali Makky onderzoeker