WorldCat Identities

Kastner, Anne

Works: 1 works in 1 publications in 1 language and 1 library holdings
Roles: Other
Publication Timeline
Most widely held works by Anne Kastner
Rôle de la mPGES-1 dans le développement de l'inflammation chronique de bas seuil et de l'obésité by Clément Pierre( )

1 edition published in 2018 in French and held by 1 WorldCat member library worldwide

Obesity is a disease characterized by an excess of nutrients and a positive energetic balance, which, in the long term, leads to major health problems. Obesity is associated with a chronic low grade inflammation at central structures and peripheral organs. Among the affected organs, the inflammation of adipose tissues seems to play a key role in the development of this disease. The prostaglandin E2 (PGE2) is a well-known mediator of inflammation whose expression is dysregulated over obesity. The final step of PGE2 synthesis is catalyzed by several prostaglandin E synthases (PGES), but only the microsomal PGES-1 (mPGES-1) is inducible. Although PGE2 appears as a potential mediator linking obesity and inflammation, few studies have investigated the role of mPGES-1 in obesity. In this context, we showed that mPGES-1 expression is significantly decreased in adipose tissue, liver and brainstem of obese mice. Then, we observed that mice deleted for the mPGES-1 enzyme (mPGES-1-/- mice) were resistant to diet-induced adiposity. They exhibited a significant decrease in body weight and adiposity, compared with control mice fed with the same fat-diet. Interestingly, mPGES-1-/- mice also displayed a reduced inflammation of white and brown adipose tissues. This phenotype could be partly explained by maintain of stable energy expenditures at the end of the diet period, without any modification of physical activity and brown adipose tissue activity. Altogether, these results showed that mPGES-1 inhibition contributes to decrease inflammation linked to obesity, and could constitute a potential target for obesity and comorbidities treatment
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French (1)