WorldCat Identities

Lühder, Fred

Works: 31 works in 56 publications in 2 languages and 233 library holdings
Roles: dgs, Other, Author, Contributor
Publication Timeline
Most widely held works by Fred Lühder
Activin A und Follistatin bei bakteriellen Infektionen - Der Einfluss von Activin A auf Mikrogliazellen in vitro und der Einfluss von Follistatin auf den Verlauf einer E. coli-K1-Sepsis im Mausmodell by Catharina Dießelberg( )

2 editions published in 2012 in German and held by 22 WorldCat member libraries worldwide

High concentrations of Activin A and Follistatin can be found in the cerebrospinal fluid (CSF) of patients with bacterial meningitis. Patients suffering from a sepsis have increased concentrations of Activin A and Follistatin in serum. In this study the effect of Activin A on microglial cells during infection was tested in vitro. Murine microglial cells were stimulated with Activin A 13 æg/ml, 13 ng/ml, 1.3 ng/ml and 0.13 ng/ml and co-stimulated with different TLR-agonists (P3C 0.1 [mu]g/ml, CpG 1 [mu]g/ml, LPS 0.01 [mu]g/ml). After stimulation
Dosisabhängige Aktivierung von Mikrogliazellen durch Toll-like-Rezeptoragonisten allein und in Kombination by Steffi Werner( )

2 editions published in 2013 in German and held by 22 WorldCat member libraries worldwide

We investigated the effects of treatment from murine microglial cells with agonists of TLR2, TLR4 and TLR9. For this reason murine microglial cell cultures were applied. We used the TLR agonists Pam3Cys, HKAL (TLR2), pneumolysin, LPS (TLR4) and CPG (TLR9) Stimulation of murine microglial cells with different TLR agonists led to the release of NO and TNF-a. By using different concentrations of TLR agonists dose-response-relations for the release of NO and TNF-a could be displayed. Based on the EC50 the potencies of TLR ligands could be evaluated. LPS was most potent in releasing NO followed
Ein transgenes Maussystem zur Untersuchung der Bedeutung der T Zellrezeptor-abhängigen und -unabhängigen CD28 vermittelten Signaltransduktion für T-Zellaktivierung, Homöostase und Autoimmunität : Schlussbericht für das Vorhaben by Fred Lühder( )

2 editions published in 2001 in German and held by 19 WorldCat member libraries worldwide

T cell, CD28, costimulation, signal transduction, monoclonal antibodies, epitope
Die Rolle des ko-stimulatorischen Moleküls CD28 in verschiedenen Phasen der EAE by Johannes Hufschmidt( )

3 editions published between 2017 and 2018 in German and held by 14 WorldCat member libraries worldwide

This dissertation summarizes the different effects of the co-stimulating molecule CD28 in different phases of EAE, especially regarding the effects on activation markers (e.g. CD44), pro-inflammatory cytokines (like IFN-y and IL-17), on proliferation of T cells, the clinical course of EAE and the role of regulatory T cells
Der Einfluss oraler Vitamin-D-Gabe auf das Immunsystem der Maus bei der experimentellen E.-coli-Meningitis by Nadine Margarete Sostmann( )

3 editions published between 2017 and 2018 in German and held by 14 WorldCat member libraries worldwide

The bacterial meningitis, which affects neonates and premature infants as well as geriatric and immunocompromised people, represents a serious infection of the central nervous system. Despite antibiotic therapy this disease leads to death in 20 % of the cases. Even after the survival of the disease neurological and neuropsychological late effects may occur in up to 70 %. Furthermore, the increase of multiresistant strains such as E. coli may complicate the therapy considerably. Current studies show that vitamin D plays an important role in the fight against infection and inflammatory reacti
Immunologisches Profil und PrPC-Expression von Patienten mit subkortikaler vaskulärer Enzephalopathie und vaskulärem kognitivem Impairment by Panteleimon Oikonomou( )

3 editions published between 2016 and 2017 in German and held by 11 WorldCat member libraries worldwide

The impact of vascular cognitive impairment (VCI) in society is increasing. Subcortical vascular encephalopathy (SVE) is the most common cause of VCI and is manifested mainly by White Matter Lesions (WMLs) and clinical symptoms including cognitive impairment, gait and micturition disorders. Inflammatory and oxidative stress mechanisms have been proposed as important factors in the pathophysiology of SVE. There are also indications that the cytokine-mediated interaction between neurons and glial cells can contribute to cognitive impairment. In addition, a small vessel disease promotes neurod
Vergleich primärer Peritonealmakrophagen und Mikrogliazellen von jungen und alten Mäusen bezüglich ihrer Bakterienphagozytose und Freisetzung inflammatorischer Mediatoren in vitro by Annika Kaufmann( )

2 editions published in 2016 in German and held by 11 WorldCat member libraries worldwide

Bacterial infections of the central nervous system (CNS) are life-threatening diseases, which can lead to death in an acute setting and result in neurological or neuropsychological sequelae as frequent complications. Older persons generally have greater susceptibility to bacterial infections and a much worse outcome after bacterial CNS infections than younger persons. With the increase in average life span for both men and women, the incidence of age-associated infections will expand and present a more serious public health concern. In view of recent rise of antibiotic-resistant bacteria an
Wirkmechanismen von Glukokortikoiden im Mausmodell der EAE - Einfluss auf Effektor- und Bystander-T-Zellen und Relevanz der T-Zell-Apoptose by Lisa Maria Müller( )

2 editions published in 2015 in German and held by 11 WorldCat member libraries worldwide

In the present study, mechanisms of glucocorticoid (GC) therapy were investigated using experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. For this purpose, active EAE was induced in C57BL/6 mice and in mice with a point mutation in the glucocorticoid receptor (GRdim and lckGRdim mice) by immunization with MOG35-55. First, we wanted to examine the effect of dexamethasone (Dex) on bystander and effector T cells. For this, a model should be established in which GCs are able to act only on bystander or effector T cells. Despite numerous experiments, no mode
Die Rolle verschiedener Virulenzfaktoren von Streptococcus pneumoniae bei der Meningitis: Untersuchung am Mausmodell by Tammo Helmut Kunst( )

2 editions published between 2014 and 2015 in German and held by 11 WorldCat member libraries worldwide

The present study examines virulence factors of S. pneumoniae in mouse model. After intracerebral injection virulence factors of D39-wild-type S. pneumoniae were compared with isogenetic derivates. These infection strains showed deficiency in one virulence factor (Ply, Hyl, NanA or NanB). Target parameters were clinic (vigilance, motor ability, loss of weight), bacteriology (in blood, cerebellum, spleen) as well as the morphological image (meningeal inflammatory score, neuronal damage defect). Ply-/- and D39-infectiongroup were compared in overall survival. The result showed statistically s
Activation of murine microglial cells by muramyl dipeptide alone and in combination with Toll-like receptor agonists by Nina Adam( )

2 editions published in 2014 in English and held by 11 WorldCat member libraries worldwide

Meningitis, meningoencephalitis and sepsis are severe diseases causing many deaths all over the world every year. Escherichia coli (E. coli) is the most common Gram-negative bacterium causing neonatal meningitis and sepsis but also causes meningitis in old and immunocompromised people. Especially immunocompromised patients carry a high risk of developing infections e.g. in the central nervous system (CNS) caused by different pathogens, such as bacteria, viruses and fungi. One cause of this increased susceptibility to CNS infections might be a decreased local immune defense. Microglial cells
Die Rolle des antiapoptotischen Gens Gimap5 für die Pathogenese neuroinflammatorischer Erkrankungen by Ann-Kathrin Witte( )

2 editions published in 2017 in German and held by 11 WorldCat member libraries worldwide

T-cell lymphopenia is a major risk factor for autoimmunity. A loss-of-function mutation in the Gimap5 gene leads to a reduction in peripheral T-cell numbers in Congenic Lewis rats. Gimap5-deficient Lewis rats developed eosinophilic autoimmune gastroenteritis accompanied by an increase in IgE serum levels. This phenotype was ameliorated by antibiotic treatment, indicating a critical role of the microbial flora in the development of inflammatory bowel disease. Gimap5-deficient Lewis rats showed strongly aggravated experimental autoimmune encephalomyelitis after immunization with guinea pig my
Myeloid corticoid receptors in CNS autoimmunity: Old targets for novel therapies by Elena Montes Cobos( )

2 editions published in 2016 in English and held by 11 WorldCat member libraries worldwide

Since the 1950s, glucocorticoids (GCs) have been the most widely employed drugs in the treatment of inflammatory and autoimmune disorders, such as multiple sclerosis (MS). Short-time application of high-dose GCs is the first line therapy for acute relapses of MS. Several clinical studies even suggest that prolonged GC pulsed therapy may slow down MS disease progression as well. However, a plethora of GC-associated side effects derived from the ubiquitous expression of the glucocorticoid receptor (GR) restricts the use of these drugs. Therefore, to assess the full potential of GCs new pharma
Gesteigerte hippokampale Neurogenese nach experimenteller bakterieller Meningitis mit Streptococcus pneumoniae by Judith Bering( )

2 editions published in 2014 in German and held by 11 WorldCat member libraries worldwide

Bacterial meningitis remains a severe disease with high mortality rate. Despite of effective antibiotic therapy a lot of patients suffer from complications and long-term sequelae. The neuronal damage of the hippocampus is a well known attribute in bacterial meningitis - in animal model as well as in humans. The validation of increased neurogenesis after bacterial meningitis in animal model therefore represents an important observation. We investigate the apoptotic and neuroregenerative process in animals with induced bacterial meningitis by Streptococcus pneumoniae. We use two well establis
Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier by Judith Hauptmann( )

2 editions published in 2020 in English and held by 5 WorldCat member libraries worldwide

Abstract: The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Herein, we studied the role of IL-1 signaling in blood-brain barrier (BBB) endothelial cells (ECs), astrocytes and microglia for EAE development, using mice with the conditional deletion of its signaling receptor IL-1R1. We found that IL-1 signaling in microglia and astrocytes is redundant for the development of EAE, whereas the IL-1R1 deletion in BBB-ECs markedly ameliorated disease severity. IL-1 signaling in BBB-ECs upregulated the expression of the adhesion molecules Vcam-1, Icam-1 and the chemokine receptor Darc, all of which have been previously shown to promote CNS-specific inflammation. In contrast, IL-1R1 signaling suppressed the expression of the stress-responsive heme catabolizing enzyme heme oxygenase-1 (HO-1) in BBB-ECs, promoting disease progression via a mechanism associated with deregulated expression of the IL-1-responsive genes Vcam1, Icam1 and Ackr1 (Darc). Mechanistically, our data emphasize a functional crosstalk of BBB-EC IL-1 signaling and HO-1, controlling the transcription of downstream proinflammatory genes promoting the pathogenesis of autoimmune neuroinflammation
Studie zur Untersuchung des Antibiotika-Einflusses auf Mikrobiom-assoziierte Schlaganfallfolgen im Mausmodell = Study to investigate the influence of antibiotics on microbiome-associated stroke consequences in a mouse model by Katrin Schröder( )

2 editions published in 2021 in German and held by 4 WorldCat member libraries worldwide

Stroke is the third leading cause of death in Germany and the most common cause of acquired disability. Primary treatment options are limited by a time window and interventions in ischaemic stroke are limited to lysis therapy and interventional or surgical thrombectomy. In addition, neuroprotective therapy is desirable to limit further neuronal tissue damage in the penumbra due to post-ischaemic processes. In this study, the influence of the intestinal microbiome on post-ischaemic inflammatory destruction after middle cerebral artery occlusion (MCAO) was investigated in mice with a 30-minut
Untersuchungen zum Inflammasom bei proinflammatorischem Zellstress des Muskels in vitro und in vivo = Analysis of the inflammasome due to proinflammatory cell stress in vitro and in vivo by Imke Bertram( )

2 editions published in 2021 in German and held by 4 WorldCat member libraries worldwide

The inclusion body myositis (IBM) is the most common acquired inflammatory myopathy with an onset of the disease from the age of 50. With a combination of degeneration and inflammation it is unique within the group of idiopathic inflammatory myopathies. There has been a description of some links between both pathways, but most of the pathogenesis remains unclear. Earlier findings show that endogenous cell stress and protein accumulation function as activators of pro-inflammatory protein complexes and also being found within biopsies of IBM patients, it seems to be a natural approach to dete
Der Einfluss von Methylprednisolon auf Migration und Subpopulationen humaner Monozyten by Tobias Lukas Klaus Finck( )

2 editions published in 2022 in German and held by 4 WorldCat member libraries worldwide

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). One of its hallmarks is the infiltration of mononuclear cells into the CNS and inflammation of the brain. Among other cells of the immune system, monocytes play an important role in the pathogenesis of the disease. In addition to their supporting function as antigen-presenting cells, they exert independent functions that, on the one hand, lead to tissue damage and progression of the disease. On the other hand, however, monocytes also possess regulatory capabilities that can promote anti-inflammation and ti
Regulation von T-Zellantworten gegen körpereigene und Tumorantigene durch Antigenpräsentation und Kostimulation by Fred Lühder( Book )

1 edition published in 2007 in German and held by 4 WorldCat member libraries worldwide

Toll-like-Rezeptoren in der Pathogenese der allergischen Kontaktdermatitis = Toll-like receptors in the pathogenesis of allergic contact dermatitis by Emilia Loewe( )

2 editions published in 2022 in German and held by 4 WorldCat member libraries worldwide

Die allergische Kontaktdermatitis ist eine induzierbare pathologische Immunreaktion, bei der Komponenten des angeborenen und des erworbenen Immunsystems eng zusammenwirken. Zahlreiche Aspekte der Feinregulation sind nicht vollständig geklärt und komplex. Die vorliegende Arbeit analysiert immunologische Vorgänge bei vier Mauslinien (C57BL/6-Wildtyp-Mäuse, MyD88-defiziente, TLR3-defiziente und MyD88/TLR3-doppeldefiziente Mäuse) und vergleicht deren kontaktallergische Immunantworten miteinander. Die Ergebnisse sprechen dafür, dass die Signalübertragung durch MyD88 bei der Pathogenese der Konta
Direct, indirect and longitudinal immunological effects of anti-CD20 mediated B cell depletion in Multiple Sclerosis by Nitzan Nissimov( )

2 editions published in 2021 in English and held by 4 WorldCat member libraries worldwide

B cell depletion via anti-CD20 antibodies is a highly effective treatment for multiple sclerosis (MS). However, little is known about the maturation/activation stage of the returning B cell population after treatment cessation and the wider effects on other immune cells. In the present study, 15 relapsing-remitting MS patients receiving 1,000 mg of rituximab were included. B, T, and myeloid cells were analyzed before anti-CD20 administration and in different time intervals thereafter over a period of 24 mo. In comparison to the phenotype before anti-CD20 treatment, the reappearing B cell po
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Associated Subjects
German (34)

English (8)