WorldCat Identities

Radsak, Markus Philipp 1973-

Overview
Works: 18 works in 20 publications in 2 languages and 49 library holdings
Roles: Other, Author, Contributor
Publication Timeline
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Most widely held works by Markus Philipp Radsak
Hemmbarkeit von humanen T-Zellen durch den FLT3-Kinase-Inhibitor Midostaurin im Vergleich zum SRC-Kinase-Inhibitor Dasatinib by Christine Höding( )

2 editions published in 2016 in German and held by 13 WorldCat member libraries worldwide

MHC-Klasse-II-Expression durch polymorphkernige Neutrophile akzessorische Zellen zur Aktivierung von T-Zellen by Markus Philipp Radsak( Book )

2 editions published in 1999 in German and held by 6 WorldCat member libraries worldwide

ERK3/MAPK6 controls IL-8 production and chemotaxis by Katarzyna Bogucka( )

1 edition published in 2020 in English and held by 3 WorldCat member libraries worldwide

Abstract: ERK3 is a ubiquitously expressed member of the atypical mitogen activated protein kinases (MAPKs) and the physiological significance of its short half-life remains unclear. By employing gastrointestinal 3D organoids, we detect that ERK3 protein levels steadily decrease during epithelial differentiation. ERK3 is not required for 3D growth of human gastric epithelium. However, ERK3 is stabilized and activated in tumorigenic cells, but deteriorates over time in primary cells in response to lipopolysaccharide (LPS). ERK3 is necessary for production of several cellular factors including interleukin-8 (IL-8), in both, normal and tumorigenic cells. Particularly, ERK3 is critical for AP-1 signaling through its interaction and regulation of c-Jun protein. The secretome of ERK3-deficient cells is defective in chemotaxis of neutrophils and monocytes both in vitro and in vivo. Further, knockdown of ERK3 reduces metastatic potential of invasive breast cancer cells. We unveil an ERK3-mediated regulation of IL-8 and epithelial secretome for chemotaxis
Diagnostic value of sTREM-1, IL-8, PCT, and CRP in febrile neutropenia after autologous stem cell transplantation by C. S Michel( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Phenotypic characterisation of pro-inflammatory monocytes and dendritic cells in peripheral arterial disease( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Influence of exercise training on proangiogenic TIE-2 monocytes and circulating angiogenic cells in patients with peripheral arterial disease by Jörn F Dopheide( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis by Astrid Alflen( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Adding dasatinib to intensive treatment in core-binding factor acute myeloid leukemia--results of the AMLSG 11-08 trial by Peter Paschka( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Idelalisib impairs TREM-1 mediated neutrophil inflammatory responses by Astrid Alflen( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Author Correction: ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis by Astrid Alflen( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Recurrent somatic mutations are rare in patients with cryptic dyskeratosis congenita by Martin Kirschner( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

CD11b regulates fungal outgrowth but not neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis by Daniel Teschner( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Soluble triggering receptor expressed on myeloid cells 1 in lung cancer by Andreas Kümmel( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Immunmodulation durch Toll-like-Rezeptoren Auf dem Weg zu einer neuen Tumortherapie? by Markus Philipp Radsak( Book )

1 edition published in 2008 in German and held by 2 WorldCat member libraries worldwide

Granulocyte functions are independent of arginine availability( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

Abstract : Granulocyte viability, phagocytosis, IL-8 secretion, chemotaxis, and antifungal activity are completely preserved in the absence of extracellular arginine. Abstract : Arginine depletion via myeloid cell arginase is critically involved in suppression of the adaptive immune system during cancer or chronic inflammation. On the other hand, arginine depletion is being developed as a novel anti-tumor metabolic strategy to deprive arginine-auxotrophic cancer cells of this amino acid. In human immune cells, arginase is mainly expressed constitutively in PMNs. We therefore purified human primary PMNs from healthy donors and analyzed PMN function as the main innate effector cell and arginase producer in the context of arginine deficiency. We demonstrate that human PMN viability, activation-induced IL-8 synthesis, chemotaxis, phagocytosis, generation of ROS, and fungicidal activity are not impaired by the absence of arginine in vitro. Also, profound pharmacological arginine depletion in vivo via ADI-PEG20 did not inhibit PMN functions in a mouse model of pulmonary invasive aspergillosis; PMN invasion into the lung, activation, and successful PMN-dependent clearance of Aspergillus fumigatus and survival of mice were not impaired. These novel findings add to a better understanding of immunity during inflammation-associated arginine depletion and are also important for the development of therapeutic arginine depletion as anti-metabolic tumor therapy
The skin as an orchestrator of influenza immunity( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

 
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Alternative Names
Markus Radsak onderzoeker

Radsak, Markus 1973-

Radsak, Markus P. 1973-

Languages
English (15)

German (5)