WorldCat Identities

Toyoizumi, Taro

Overview
Works: 2 works in 2 publications in 2 languages and 2 library holdings
Publication Timeline
.
Most widely held works by Taro Toyoizumi
Shūsengo shōwa nijūyonen shimofusa shochō o haimei jirai sanjūichinen shochō no nennen saisai no ki de aru( Book )

1 edition published in 1980 in Japanese and held by 1 WorldCat member library worldwide

Calcineurin knockout mice show a selective loss of small spines( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Highlights: Knockout of calcineurin reduced small spines in the prefrontal and visual cortices. The reduction was moderate, possibly due to the presence of intrinsic spine dynamics. Calcineurin knockouts and patients with schizophrenia have similar spine phenotypes. Abstract: Calcineurin is required for long-term depression and activity-dependent spine shrinkage, and calcineurin mutations have been identified in patients with schizophrenia. Moreover, mice with conditional knockout of calcineurin B (CNB-KO) exhibit behavioral abnormalities suggestive of schizophrenia. Changes in the dendritic spines of these mice, however, have not been investigated. We therefore examined the dendritic spines of CNB-KO mice, and observed a significant reduction in small spines and an increase in large spines in the prefrontal and visual cortices. The effect of CNB-KO on the spine sizes was relatively moderate, possibly due to the presence of spontaneous fluctuations (dynamics) in the dendritic spines themselves. Thus, CNB-KO mice showed a spine phenotype similar to those recently reported in patients with schizophrenia
 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.93 (from 0.88 for Calcineuri ... to 0.97 for Shūsengo ...)

Alternative Names
Toyoizumi, Taro 1910-

トヨイズミ, タロウ 1910-

Languages