WorldCat Identities

Kanagaratnam, Lukshe

Overview
Works: 6 works in 6 publications in 2 languages and 10 library holdings
Roles: Author
Publication Timeline
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Most widely held works by Lukshe Kanagaratnam
Psoriasis After Exposure to Angiotensin-Converting Enzyme Inhibitors: French Pharmacovigilance Data and Review of the Literature by Brahim Azzouz( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

In vivo efficacy of endothelial growth medium stimulated mesenchymal stem cells derived from patients with critical limb ischemia by Rida Al-Rifai( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Prevalence of geophagy and knowledge about its health effects among native Sub-Saharan Africa, Caribbean and South America healthy adults living in France by Perrine Decaudin( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Facteurs de risque de survenue indésirables médicamenteux chez le sujet âgé hospitalisé dans une unité spécialisée dans la prise en charge des maladies démentielles by Lukshe Kanagaratnam( Book )

1 edition published in 2012 in French and held by 2 WorldCat member libraries worldwide

Les troubles du comportement sont une composante bien identifiée chez les patients souffrant de syndrome démentiel. Parmi les nombreuses étiologies à ces troubles, les effets indésirables médicamenteux ne sont pas les moins fréquents. L'objectif principal de cette étude était d'identifier les facteurs de risque de survenue d'effets indésirables médicamenteux chez des personnes âgées présentant des troubles cognitifs. Une étude épidémiologique transversale a été menée dans l'unité aiguë de médecine gériatrique spécialisée dans la prise en charge des maladies démentielles au CHU de Reims entre mai 2010 et novembre 2011. Les variables sociodémographiques, d'évaluation gériatrique standardisée et biologiques ont été recueillies. La présence d'effets indésirables a été recherchée à l'entrée et au cours de l'hospitalisation chez tous les patients inclus grâce à une double évaluation (médecin gériatre et médecin pharmacovigilant). Les facteurs de risque de survenue d'un effet indésirable ont été identifiés par une régression logistique. Au total, 293 patients âgés de 82±8 ans ont été inclus dans l'étude, avec une majorité de femmes (61 %). L'évaluation cognitive avait retrouvé un score MMSE de 13±8 ; 84 % (245) prenaient aux moins cinq médicaments différents à l'admission. Parmi les 293 patients, 24 % (70) ont présenté au moins un effet indésirable, un sur deux était classé en effet indésirable grave. Le risque d'effets indésirables était significativement plus élevé en cas de polymédication (OR= 3,8 ; IC 95%= 1,1-13,3), et de dépendance (perte d'au moins un ADL) (OR= 2,8 ; IC95%= 1,1-6,8). Par ailleurs, les personnes de plus de 85 ans avaient un risque d'effet indésirable plus faible que les personnes de moins de 85 ans (OR= 0,5 ; IC 95%= 0,2-0,9). Les médicaments sont impliqués dans la survenue d'effet indésirable médicamenteux à deux niveaux, d'une part par le nombre élevé de médicament et d'autre part par leur classe thérapeutique. L'éducation thérapeutique de l'aidant est primordiale dans la prise en charge du sujet âgé présentant des troubles cognitives
Transformed Waldenström macroglobulinaemia: clinical presentation and outcome. A multi-institutional retrospective study of 77 cases from the French Innovative Leukemia Organization (FILO)( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Histological transformation (HT) to diffuse large B-cell lymphoma (DLBCL) is a rare and poorly reported complication of Waldenström macroglobulinaemia (WM). We performed a retrospective study of 77 WM patients with biopsy-proven transformation to DLBCL. The median time from WM diagnosis to HT was 4·6 years and 16 patients (21%) had never been treated for WM. At HT, extranodal sites were observed in 91% of patients with a rather high incidence of central nervous system, cutaneous or testicular involvement. Fluorodeoxyglucose-positron emission tomography was performed in half of the patients and the median maximum standardized uptake value was 15 for transformed disease. More than 80% of cases with available data for assessment by the Hans' algorithm harboured a non-germinal centre B-cell phenotype. First-line treatment for transformation consisted of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone)-like regimen in 85% of patients. The overall response rate after first-line treatment was 61% and the median overall survival was only 16 months for the entire cohort. Time to transformation above 5 years (P = 0·0004) and elevated LDH (P = 0·02) were associated with worse outcome. Based on these findings, HT should be considered and lead to a biopsy in WM patients presenting with extranodal involvement, elevated LDH and constitutional symptoms. The optimal therapeutic approaches remain to be defined
Effets indésirables médicamenteux chez les sujets âgés atteints de maladie d'Alzheimer ou syndromes apparentés by Lukshe Kanagaratnam( )

1 edition published in 2017 in French and held by 1 WorldCat member library worldwide

All forms of dementia, particularly Alzheimer's disease, are increasing in line with population ageing. In this population, there are few data available regarding the prevalence and risk factors of adverse drug reaction (ADR). For this reason, one of the measures of the French government initiative for Alzheimer's disease for the period 2008-2012 was to improve the state of the knowledge on ADR in this population. The aims of this PhD thesis were to describe ADRs, drug suspected in the occurrence of these ADRs and to identify the risk factors for the occurrence of ADR in older subjects hospitalised in an acute geriatric medicine ward specialised in the management of patients with dementia syndrome. An ad hoc study was conducted in this population. This study was completed by data from Regional Pharmacovigilance Center of Champagne-Ardenne and a systematic review of the literature. Caution is needed when prescribing angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers, neuroleptics, antidementia drugs, or certain types of antiarrhythmics in patients suffering from dementia. Our findings underline the importance of taking into consideration the characteristics of the patients when prescribing drugs in this specific population. Early detection of dependency in cognitive impaired subjects and the implementation of home help could help to avoid ADRs related to errors in taking medications
 
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