WorldCat Identities

Algra, Ale

Overview
Works: 18 works in 26 publications in 1 language and 40 library holdings
Genres: History 
Roles: Other, Author, dgs
Classifications: DJ109, 949.2
Publication Timeline
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Most widely held works by Ale Algra
"Dispereert niet" : twintig eeuwen historie van de Nederlanden by A Algra( Book )

3 editions published between 1855 and 1965 in Undetermined and held by 4 WorldCat member libraries worldwide

"Dispereert niet" : twintig eeuwen historie van de Nederlanden by A Algra( Book )

2 editions published between 1946 and 1961 in Undetermined and held by 3 WorldCat member libraries worldwide

"Dispereert niet" : twintig eeuwen historie van de Nederlanden by A Algra( Book )

2 editions published between 1949 and 1963 in Undetermined and held by 3 WorldCat member libraries worldwide

"Dispereert niet" : twintig eeuwen historie van de Nederlanden by A Algra( Book )

2 editions published between 1948 and 1962 in Undetermined and held by 3 WorldCat member libraries worldwide

Prothrombotic factors and the risk of myocardial infarction and ischaemic stroke in young women ; differences, similarities and implications by B Siegerink( Book )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

"Dispereert niet" : twintig eeuwen historie van de Nederlanden by A Algra( Book )

1 edition published in 1951 in Undetermined and held by 1 WorldCat member library worldwide

Safety and feasibiLIty of Metformin in patients with Impaired glucose Tolerance and a recent TIA or minor ischemic stroke (LIMIT) trial - a multicenter, randomized, open-label phase II trial( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Abstract Background and purpose We aimed to assess the safety, feasibility, and effects on glucose metabolism of treatment with metformin in patients with TIA or minor ischemic stroke and impaired glucose tolerance. Methods We performed a multicenter, randomized, controlled, open-label phase II trial with blinded outcome assessment. Patients with TIA or minor ischemic stroke in the previous six months and impaired glucose tolerance (2-hour post-load glucose levels of 7.8-11.0 mmol/l) were randomized to metformin, in a daily dose of 2 g, or no metformin, for three months. Primary outcome measures were safety and feasibility of metformin, and the adjusted difference in 2-hour post-load glucose levels at three months. This trial is registered as an International Standard Randomized Controlled Trial Number 54960762. Results Forty patients were enrolled; 19 patients were randomly assigned metformin. Nine patients in the metformin group had side effects, mostly gastrointestinal, leading to permanent discontinuation in four patients after 3-10 weeks. Treatment with metformin was associated with a significant reduction in 2-hour post-load glucose levels of 0·97 mmol/l (95% CI 0·11-1·83) in the on-treatment analysis, but not in the intention-to-treat analysis (0·71 mmol/l; 95% CI −0·36 to 1·78). Conclusions Treatment with metformin in patients with TIA or minor ischemic stroke and impaired glucose tolerance is safe, but leads to minor side effects. If tolerated, it may lead to a significant reduction in post-load glucose levels. This suggests that the role of metformin as potential therapeutic agent for secondary stroke prevention should be further explored
"Dispereert niet" : twintig eeuwen historie van de Nederlanden by A Algra( Book )

1 edition published in 1948 in Undetermined and held by 1 WorldCat member library worldwide

Dispereert niet : twintig eeuwen historie van de Nederlanden by A Algra( Book )

1 edition published in 1948 in Undetermined and held by 1 WorldCat member library worldwide

No benefits of hypothermia in patients treated with hemicraniectomy for large ischemic stroke( )

in English and held by 1 WorldCat member library worldwide

Background Space-occupying middle cerebral artery brain infarcts are associated with the development of brain edema, which may lead to cerebral herniation and death despite early hemicraniectomy. Aims To evaluate the benefit of therapeutic hypothermia in patients with space-occupying cerebral infarction treated with hemicraniectomy within 48 h of stroke onset. Methods Patients aged 18-60 years with space-occupying cerebral infarction treated with hemicraniectomy within 48 h and hypothermia (33-34°C) were selected from a single university hospital between 2001 and 2010 (n = 53). Patients treated with hemicraniectomy alone served as comparison group (n = 58), originating from three randomized controlled trials evaluating the effects of early decompressive surgery (DECIMAL, DESTINY, HAMLET). Primary outcome was the score on the modified Rankin scale at 12 months dichotomized between modified Rankin scale 0-3 and modified Rankin scale 4-6. Secondary outcome measures were modified Rankin scale score 0-4 and survival. Risk ratios were adjusted with Poisson regression. Results Mean patient age was 48 years. Median time from stroke onset to hemicraniectomy was 23.5 h in both treatment groups. Treatment with hypothermia had no effect on the primary outcome (modified Rankin scale 0-3 versus 4-6 (13/53 (25%) versus 24/58 (41%)); adjusted risk ratio 0.66, 95% confidence interval 0.38-1.13). Fewer patients treated with hypothermia had a modified Rankin scale score of 0-4 (21/53 (40%) versus 42/58 (72%); adjusted risk ratio 0.53, 95% confidence interval 0.37-0.76) and fewer patients survived (26/53 (49%) versus 46/58 (79%); adjusted risk ratio 0.60, 95% confidence interval 0.44-0.82). Conclusions In patients with space-occupying cerebral infarction, treatment with hypothermia had no additional benefit on functional outcome compared with treatment with hemicraniectomy alone
"Dispereert niet" : twintig eeuwen historie van de Nederlanden by A Algra( Book )

1 edition published in 1953 in Undetermined and held by 1 WorldCat member library worldwide

PHASES Score for Prediction of Intracranial Aneurysm Growth( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Abstract : Background and Purpose--: Growth of an intracranial aneurysm occurs in around 10% of patients at 2-year follow-up imaging and may be associated with aneurysm rupture. We investigated whether PHASES, a score providing absolute risks of aneurysm rupture based on 6 easily retrievable risk factors, also predicts aneurysm growth. Methods--: In a multicenter cohort of patients with unruptured intracranial aneurysms and follow-up imaging with computed tomography angiography or magnetic resonance angiography, we performed univariable and multivariable Cox regression analyses for the predictors of the PHASES score at baseline, with aneurysm growth as outcome. We calculated hazard ratios and corresponding 95% confidence intervals (CI), with the PHASES score as continuous variable and after division into quartiles. Results--: We included 557 patients with 734 unruptured aneurysms. Eighty-nine (12%) aneurysms in 87 patients showed growth during a median follow-up of 2.7 patient-years (range 0.5-10.8). Per point increase in PHASES score, hazard ratio for aneurysm growth was 1.32 (95% CI, 1.22-1.43). With the lowest quartile of the PHASES score (0-1) as reference, hazard ratios were for the second (PHASES 2-3) 1.07 (95% CI, 0.49-2.32), the third (PHASES 4) 2.29 (95% CI, 1.05-4.95), and the fourth quartile (PHASES 5-14) 2.85 (95% CI, 1.43-5.67). Conclusions--: Higher PHASES scores were associated with an increased risk of aneurysm growth. Because higher PHASES scores also predict aneurysm rupture, our findings suggest that aneurysm growth can be used as surrogate outcome measure of aneurysm rupture in follow-up studies on risk prediction or interventions aimed to reduce the risk of rupture
"Dispereert niet" : twintig eeuwen historie van de Nederlanden by A Algra( Book )

1 edition published in 1946 in Undetermined and held by 1 WorldCat member library worldwide

Time Course and Risk Factors for Myocardial Dysfunction After Aneurysmal Subarachnoid Hemorrhage( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Abstract : BACKGROUND: Myocardial wall motion abnormalities (WMAs) are independent risk factors for a poor outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). OBJECTIVE: To study the time course of WMAs during the initial phase after aSAH and to investigate which clinical, electrocardiographic, or myocardial serum markers are predictors of early or late development of WMAs. METHODS: In a prospective, multicenter cohort study in patients with aSAH, we performed serial electrocardiography and echocardiography and measured troponin T and N-terminal pro-B-type natriuretic peptide. WMAs present on admission were considered early WMAs; those that developed during the clinical course were considered late WMAs. Using multivariable regression analysis, we calculated odds ratios with corresponding 95% confidence intervals for clinical parameters, electrocardiography, and myocardial serum makers with early or late occurrence of WMAs. RESULTS: We included 301 patients (mean age ± SD, 57 ± 13) years. Multivariable odds ratios for early WMAs were poor clinical condition, 2.7 (95% confidence interval: 1.1-6.8); sinus tachycardia, 5.0 (1.3-19.9); ST-segment depression, 3.7 (1.02-13.1); ST-segment elevation, 16.6 (1.5-178.9); and increased troponin T, 2.8 (1.1-7.3). Multivariable odds ratios (95% confidence intervals) for late development of WMAs were 6.8 (1.6-30) for a myocardial infarct pattern on admission electrocardiography and 3.4 (1.4-8.5) for increased troponin T on admission. CONCLUSION: WMAs may be present on admission or develop during the course of aSAH. Poor neurological condition on admission, sinus tachycardia, ST-segment depression, and ST-segment elevation on admission electrocardiography and increased troponin T are independent predictors of early WMAs; a myocardial infarct pattern on admission ECG and increased troponin T independently predict late WMAs. CLINICAL TRIAL REGISTRATION: NCT00123695. ABBREVIATIONS: aSAH, aneurysmal subarachnoid hemorrhage CI, confidence interval ECG, electrocardiography OR, odds ratio WMA, wall motion abnormality
"Dispereert niet" : twintig eeuwen historie van de Nederlanden by A Algra( Book )

1 edition published in 1954 in Undetermined and held by 1 WorldCat member library worldwide

Dispereert niet : twintig eeuwen historie van de Nederlanden by A Algra( Book )

1 edition published in 1948 in Undetermined and held by 1 WorldCat member library worldwide

 
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Audience level: 0.82 (from 0.79 for Electrocar ... to 0.89 for Prothrombo ...)

Alternative Names
Ale Algra academydd

Ale Algra dosen

Ale Algra Hochschullehrer

Ale Algra onderzoeker

Ale Algra profesor universitario

Ale Algra professeur d'université

Ale Algra professore universitario

Ale Algra researcher, ORCID id # 0000-0003-2858-5808

Ale Algra Universiteit onderwyser

Ale Algra universitetslærar

Ale Algra universitetslærer

Ale Algra universitetslärare

Ale Algra yliopisto-opettaja

Ale Algra أستاذ جامعي

Algra, A. 1953-

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