WorldCat Identities

Caubet Marín, Amparo

Overview
Works: 3 works in 6 publications in 3 languages and 6 library holdings
Roles: Author
Publication Timeline
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Most widely held works by Amparo Caubet Marín
Estudio espectroscópico y magnético de complejos de Co(II) con nucleótidos by Amparo Caubet Marín( Book )

3 editions published in 1989 in Spanish and held by 3 WorldCat member libraries worldwide

Diarylethene-based Pt(II) molecular switches : a novel approch to photoactivated chemotherapy by Andreu Presa i Rodríguez( Book )

2 editions published between 2016 and 2017 in English and held by 2 WorldCat member libraries worldwide

The photoactivation of metal complexes with potential anticancer activity is a hot topic of current research, as it may lead to the development of more selective and efficient drugs. Photoactivated chemotherapy (PACT) with coordination compounds is usually based on photochemical processes taking place at the metal center. In contrast, an innovative ligand-mediated photoactivation approach that exploits the outstanding photochemical properties of diarylethenes has been developed in the present PhD thesis. Platinum(II) complexes from dithienylcyclopentene-based photoswitchable ligands have been designed and prepared. These systems exhibit two thermally stable, interconvertible photoisomeric forms, which present clearly distinct properties. The photochemical behavior of all ligands and metal complexes has been examined by means of 1H NMR and UV-Vis spectroscopies, and a number of crystal structures have been determined. Additionally, DFT calculations have been performed to analyze the effect produced by the attachment of different metal-binding units on the photochemical performance of the diarylethene synthon. Subsequently, the interaction of each photoisomer of the platinum(II) complexes with DNA has been thoroughly investigated using different techniques. These studies revealed that the light-triggered transformation of these systems effectively translates into different DNA binding modes and affinities, as desired for a photoactivatable drug. The antiproliferative activity of the complexes prepared has then been evaluated through various cell viability in vitro assays, which validated the potential applications of such diarylethene-based photoswitches for the development of a new class of photochemotherapeutic metallodrugs
Síntesis, caracterización y estudio de las aplicaciones de compuestos heteropolimetálicos derivados del ferroceno by Sonia Pérez Méndez( )

1 edition published in 2005 in Catalan and held by 1 WorldCat member library worldwide

 
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