WorldCat Identities

Brøns, Charlotte

Overview
Works: 12 works in 14 publications in 1 language and 25 library holdings
Roles: Other, Author, Contributor
Publication Timeline
.
Most widely held works by Charlotte Brøns
Low birth weight and high-fat overfeeding in the pathophysiology of type 2 diabetes : metabolic, genetic transcriptional and epigenetic aspects : Ph. D. thesis by Charlotte Brøns( Book )

3 editions published between 2008 and 2009 in English and held by 6 WorldCat member libraries worldwide

Plasma ceramide levels are altered in low and normal birth weight men in response to short-term high-fat overfeeding by Amalie Ribel-Madsen( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women by Geeti P Arora( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Criterion validity and reliability of a smartphone delivered sub-maximal fitness test for people with type 2 diabetes by Cecilie Fau Brinkløv( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

The effect taurine on insulin-secretion and action in overweight men with a genetic predisposition to type 2 diabetes mellitus( Book )

1 edition published in 2002 in English and held by 2 WorldCat member libraries worldwide

36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner by Line Hjort( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Disproportionately increased 24-h energy expenditure and fat oxidation in young men with low birth weight during a high-fat overfeeding challenge by Charlotte Brøns( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding by Linn Gillberg( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Chronic Non-bacterial Osteomyelitis: A Review by Kristian Buch( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract: Low birth weight (LBW) individuals exhibit a disproportionately increased, incomplete fatty acid oxidation and a decreased glucose oxidation, compared with normal birth weight (NBW) individuals, and furthermore have an increased risk of developing insulin resistance and type 2 diabetes. We hypothesized that changes in amino acid metabolism may occur parallel to alterations in fatty acid and glucose oxidation, and could contribute to insulin resistance. Therefore, we measured fasting plasma levels of 15 individual or pools of amino acids in 18 LBW and 25 NBW men after an isocaloric control diet and after a 5-day high-fat, high-calorie diet. We demonstrated that LBW and NBW men increased plasma alanine levels and decreased valine and leucine/isoleucine levels in response to overfeeding. Also, LBW men had higher alanine, proline, methionine, citrulline, and total amino acid levels after overfeeding compared with NBW men. Alanine and total amino acid levels tended to be negatively associated with the insulin-stimulated glucose uptake after overfeeding. Therefore, the higher amino acid levels in LBW men could be a consequence of their reduction in skeletal muscle insulin sensitivity due to overfeeding with a possible increased skeletal muscle proteolysis and/or could potentially contribute to an impaired insulin sensitivity. Furthermore, the alanine level was negatively associated with the plasma acetylcarnitine level and positively associated with the hepatic glucose production after overfeeding. Thus, the higher alanine level in LBW men could be accompanied by an increased anaplerotic formation of oxaloacetate and thereby an enhanced tricarboxylic acid cycle activity and as well an increased gluconeogenesis. Abstract : Low birth weight (LBW) men had higher fasting plasma levels of several amino acids when exposed to short-term high-fat overfeeding compared with normal birth weight (NBW) men, including higher alanine, proline, methionine, citrulline, and total amino acid levels. Alanine level was negatively associated with the plasma acetylcarnitine level and positively associated with the hepatic glucose production after overfeeding, suggesting that higher alanine levels could be accompanied by an increased anaplerotic formation of oxaloacetate and thereby an enhanced tricarboxylic acid cycle activity and as well an increased gluconeogenesis
Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract: We hypothesized that an increased, incomplete fatty acid beta-oxidation in mitochondria could be part of the metabolic events leading to insulin resistance and thereby an increased type 2 diabetes risk in low birth weight (LBW) compared with normal birth weight (NBW) individuals. Therefore, we measured fasting plasma levels of 45 acylcarnitine species in 18 LBW and 25 NBW men after an isocaloric control diet and a 5-day high-fat, high-calorie diet. We demonstrated that LBW men had higher C2 and C4-OH levels after the control diet compared with NBW men, indicating an increased fatty acid beta-oxidation relative to the tricarboxylic acid cycle flux. Also, they had higher C6-DC, C10-OH/C8-DC, and total hydroxyl-/dicarboxyl-acylcarnitine levels, which may suggest an increased fatty acid omega-oxidation in the liver. Furthermore, LBW and NBW men decreased several acylcarnitine levels in response to overfeeding, which is likely a result of an upregulation of fatty acid oxidation due to the dietary challenge. Moreover, C10-OH/C8-DC and total hydroxyl-/dicarboxyl-acylcarnitine levels tended to be negatively associated with the serum insulin level, and the total hydroxyl-/dicarboxyl-acylcarnitine level additionally tended to be negatively associated with the hepatic insulin resistance index. This indicates that an increased fatty acid omega-oxidation could be a compensatory mechanism to prevent an accumulation of lipid species that impair insulin signaling. Abstract : Low birth weight (LBW) men had higher fasting plasma levels of several acylcarnitine species compared with normal birth weight (NBW) men, including higher C2 and C4-OH levels, indicating an increased fatty acid beta-oxidation relative to the tricarboxylic acid cycle flux, and higher C6-DC, C10-OH/C8-DC, and total hydroxyl-/dicarboxyl-acylcarnitine levels, suggesting an increased fatty acid omega-oxidation. Total hydroxyl-/dicarboxyl-acylcarnitine level tended to be negatively associated with the hepatic insulin resistance index, suggesting that omega-oxidation could be a scavenger pathway to prevent an accumulation of lipid species that impair insulin signaling in the liver
Complement factors C4 and C3 are down regulated in response to short term overfeeding in healthy young men( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

 
moreShow More Titles
fewerShow Fewer Titles
Audience Level
0
Audience Level
1
  General Special  
Audience level: 0.96 (from 0.88 for Complement ... to 0.97 for Low birth ...)

Languages
English (14)