WorldCat Identities

Grados, Aurélie

Works: 5 works in 5 publications in 2 languages and 8 library holdings
Roles: Author, Contributor
Publication Timeline
Most widely held works by Aurélie Grados
Caractérisation des patients atteints de la Maladie associée aux IgG4 : analyse par correspondance multiple et Cluster sur 90 patients de la cohorte nationale by Aurélie Grados( Book )

1 edition published in 2014 in French and held by 2 WorldCat member libraries worldwide

INTRODUCTION : La maladie associée aux IgG4 (MAG-4) est une maladie inflammatoire systématique de découverte récente. Les tableaux cliniques sont hétérogènes. Une meilleure individualisation des sous groupes de patients pourrait permettre de définir des attitudes thérapeutiques plus précises. MATERIELS et METHODES : Quatre-vingt-dix patients ont été inclus à partir des critères diagnostiques de la maladie. Les données démographiques, cliniques et biologiques, histologiques et thérapeutiques ont été analysées. Nous avons réalisé une analyse par correspondance multiple (ACM) à la recherche de relations pouvant exister entre les différentes caractéristiques de la maladie. Nous avons ensuite confirmé ces résultats grâce à une analyse en cluster divisant la population étudiée en trois groupes. RESULTATS : La ACM suggère une association entre le nombre d'atteintes d'organes et le taux sérique d'IgG4. L'analyse en cluster permet d'individualiser 3 groupes en fonction de ces deux paramètres. Le groupe 1 (n=60) correspond à la forme diffuse de la maladie, avec le plus souvent plus de 3 atteintes et un taux sérique d'IgG4 élevé. Le groupe 3 (n=17) présente une maladie plus localisée avec entre 1 et 3 atteintes d'organes et au taux sérique inférieur à 10g/L. Le 3ème groupe (n=10) correspond à un groupe intermédiaire. CONCLUSION : Cette étude permet de classer les patients atteints de la MAG-4 en fonction du nombre, du type d'atteinte et du taux sérique d'IgG4. L'individualisation de ces sous groupes pourrait avoir un intérêt pour orienter la prise en charge thérapeutique de ces patients
Clinical value of a [18F]-FDG PET-CT muscle-to-muscle SUV ratio for the diagnosis of active dermatomyositis by Nihal Martis( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

A new family with hereditary lysozyme amyloidosis with gastritis and inflammatory bowel disease as prevailing symptoms by Estelle Jean( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

Ophthalmic manifestations in IgG4-related disease( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract : Abstract: IgG4-related disease (IgG4-RD) is characterized by variable tissue or organ involvements sharing common pathological findings. Orbital or orbital adnexa involvement of the disease has been reported in a few case series. The aim of our study was to characterize and analyze ophthalmic manifestations from a nationwide French case-series. Patients with IgG4-RD and orbital or orbital adnexa involvement included in the French multicentric IgG4-RD case-registry were identified. Only patients fulfilling "modified" comprehensive diagnostic criteria with pathological documentation were retained for the study. Clinical, biological, pathological, radiological findings and data regarding the response to treatment were retrospectively analyzed. According to our data registry, the frequency of IgG4-related ophthalmic disease (IgG4-ROD) was 17%. Mean age at diagnosis was 55.1 ± 7.1 years with a male/female ratio of 2.2. The 19 cases of IgG4-ROD consisted of lacrimal gland (68.4%), soft tissue (57.9%), extra-ocular muscles (36.8%), palpebral (21.1%), optical nerve (10.5%), orbital bone (10.5%), and mononeuritis (V1 and/or V2, 10.5%) involvements. IgG4-ROD was bilateral in 57.9% of cases. Extra-ophthalmic manifestations were reported in 78.9% of cases. All patients responded to prednisone but two-thirds of patients relapsed within a mean (SD) of 9.8 (3.5) months and 72.2% required long-term glucocorticoids and/or immunosuppressive agents. Eight patients were treated by rituximab with a favorable response in 87.5% of cases. Lacrimal involvement is the most frequent ophthalmic manifestation of IgG4-RD and is frequently associated with extra-orbital manifestations. Despite initial favorable response to steroids, the long-term management of relapsing patients needs to be improved. Abstract : Supplemental Digital Content is available in the text
Sarcoidosis Occurring After Solid Cancer( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Abstract Abstract The association between cancer and sarcoidosis is controversial. Some epidemiological studies show an increase of the incidence of cancer in patients with sarcoidosis but only few cases of sarcoidosis following cancer treatment have been reported. We conducted a retrospective case study from internal medicine and oncology departments for patients presenting sarcoidosis after solid cancer treatment. We also performed a literature review to search for patients who developed sarcoidosis after solid cancer. We describe the clinical, biological, and radiological characteristics and outcome of these patients. Twelve patients were included in our study. Various cancers were observed with a predominance of breast cancer. Development of sarcoidosis appeared in the 3 years following cancer and was asymptomatic in half of the patients. The disease was frequently identified after a follow-up positron emission tomography computerized tomography evaluation. Various manifestations were observed but all patients presented lymph node involvement. Half of the patients required systemic therapy. With a median follow-up of 73 months, no patient developed cancer relapse. Review of the literature identified 61 other patients for which the characteristics of both solid cancer and sarcoidosis were similar to those observed in our series. This report demonstrates that sarcoidosis must be considered in the differential diagnosis of patients with a history of malignancy who have developed lymphadenopathy or other lesions on positron emission tomography computerized tomography. Histological confirmation of cancer relapse is mandatory in order to avoid unjustified treatments. This association should be consider as a protective factor against cancer relapse
Audience Level
Audience Level
  Kids General Special  
Audience level: 0.94 (from 0.88 for Sarcoidosi ... to 0.97 for Clinical v ...)