WorldCat Identities

Lange, Dariusz

Overview
Works: 11 works in 11 publications in 2 languages and 18 library holdings
Roles: Contributor, Other, Author
Publication Timeline
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Most widely held works by Dariusz Lange
Impact of HPV infection on the clinical outcome of p-CAIR trial in head and neck cancer by Miroslaw Snietura( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Two-miRNA classifiers differentiate mutation-negative follicular thyroid carcinomas and follicular thyroid adenomas in fine needle aspirations with high specificity by Tomasz Stokowy( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Stromal, rather than epithelial cyclooxygenase-2 (COX-2) expression is associated with overall survival of breast cancer patients by Justyna Urban( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

Oral and oropharyngeal papillomas are not associated with high-risk human papillomavirus infection by Miroslaw Snietura( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Prognostic significance of RBP2-H1 variant of JARID1B in melanoma by Łukasz Kuźbicki( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Molecular differential diagnosis of follicular thyroid carcinoma and adenoma based on gene expression profiling by using formalin-fixed paraffin-embedded tissues by Aleksandra Pfeifer( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Detection of metabolites discriminating subtypes of thyroid cancer: Molecular profiling of FFPE samples using the GC/MS approach( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Abstract: One of the critical issues in thyroid cancer diagnostic is differentiation between follicular adenoma, follicular carcinoma and the follicular variant of papillary carcinoma, which in some cases is not possible based on histopathological features only. In this paper we performed molecular profiling of thyroid tissue aiming to identify metabolites characteristic for different types of thyroid cancer. FFPE tissue specimens were analysed from 5 different types of thyroid malignancies (follicular, papillary/classical variant, papillary/follicular variant, medullary and anaplastic cancers), benign follicular adenoma and normal thyroid. Extracted metabolites were identified and semi-quantified using the GC/MS approach. There were 28 metabolites identified, whose abundances were significantly different among different types of thyroid tumours, including lipids, carboxylic acids, and saccharides. We concluded, that multi-component metabolome signature could be used for classification of different subtypes of follicular thyroid lesions. Moreover, potential applicability of the GC/MS-based analysis of FFPE tissue samples in diagnostics of thyroid cancer has been proved. Highlights: There were identified metabolic signatures to discriminate subtypes of thyroid cancer. Metabolomic differences between follicular thyroid lesions were identified. Mio-inositol phosphate allowed discrimination of thyroid cancers from follicular adenoma. GC/MS could be used for molecular profiling of FFPE thyroid tissues
Zbadanie ryzyka i przyczyn niezgodności w diagnostyce histopatologicznej raków tarczycy by Dariusz Lange( Book )

1 edition published in 2006 in Polish and held by 1 WorldCat member library worldwide

Somatic mutation profiling of follicular thyroid cancer by next generation sequencing( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract: The molecular etiology of follicular thyroid tumors is largely unknown, rendering the diagnostics of these tumors challenging. The somatic alterations present in these tumors apart from RAS gene mutations and PAX8 / PPARG translocations are not well described. To evaluate the profile of somatic alteration in follicular thyroid tumors, a total of 82 thyroid tissue samples derived from 48 patients were subjected to targeted Illumina HiSeq next generation sequencing of 372 cancer-related genes. New somatic alterations were identified in oncogenes (MDM2, FLI1), transcription factors and repressors (MITF, FLI1, ZNF331), epigenetic enzymes (KMT2A, NSD1, NCOA1, NCOA2), and protein kinases (JAK3, CHEK2, ALK). Single nucleotide and large structural variants were most and least frequently identified, respectively. A novel translocation in DERL / COX6C was detected. Many somatic alterations in non-coding gene regions with high penetrance were observed. Thus, follicular thyroid tumor somatic alterations exhibit complex patterns. Most tumors contained distinct somatic alterations, suggesting previously unreported heterogeneity. Highlights: The spectrum of somatic alterations in follicular thyroid tumors is largely unknown. Cancer genes in 82 thyroid tissue samples were tested by next generation sequencing. Single nucleotide variants were most common; large structural changes were rare. New somatic alterations were found in genes as well as non-coding regions. Distinct tumor somatic alterations suggested previously unreported heterogeneity
Zbadanie ryzyka i przyczyn niezgodności w diagnostyce histopatoligcznej raków tarczycy : (rozprawa habilitacyjna) by Dariusz Lange( Book )

1 edition published in 2006 in Polish and held by 1 WorldCat member library worldwide

 
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WorldCat IdentitiesRelated Identities
Alternative Names
Dariusz Lange investigador polaco

Dariusz Lange investigador polacu

Dariusz Lange investigador polonès

Dariusz Lange polski lekarz, patomorfolog

Dariusz Lange researcher

Dariusz Lange ricercatore polacco

Lange, D.

Lange D Pools onderzoeker

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