WorldCat Identities

Chrzanowska, Krystyna H.

Overview
Works: 14 works in 14 publications in 1 language and 28 library holdings
Roles: Other, Author
Publication Timeline
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Most widely held works by Krystyna H Chrzanowska
The Slavic NBN Founder Mutation: A Role for Reproductive Fitness? by Eva Seemanová( )

1 edition published in 2016 in English and held by 3 WorldCat member libraries worldwide

Correction to: Circulating T Cells of Patients with Nijmegen Breakage Syndrome Show Signs of Senescence by Ruud W. J Meijers( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Circulating T Cells of Patients with Nijmegen Breakage Syndrome Show Signs of Senescence by Ruud W. J Meijers( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

The ARID1B spectrum in 143 patients: from nonsyndromic intellectual disability to Coffin-Siris syndrome by Eline (P.J.) van der Sluijs( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Nijmegen Breakage Syndrome: Clinical and Immunological Features, Long-Term Outcome and Treatment Options - a Retrospective Analysis by on behalf of the Inborn Errors Working Party of the Society for European Blood and Marrow Transplantation and the European Society for Immune Deficiencies( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

A novel TPM2 gene splice-site mutation causes severe congenital myopathy with arthrogryposis and dysmorphic features by Magdalena Mroczek( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients by Alessandro Corti( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Nijmegen breakage syndrome (NBS) by Krystyna H Chrzanowska( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Characterization of 28 novel patients expands the mutational and phenotypic spectrum of Lowe syndrome by Florian Recker( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

Correction: The ARID1B spectrum in 143 patients: from nonsyndromic intellectual disability to Coffin-Siris syndrome by Pleuntje J. van der Sluijs( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Exome sequencing unravels unexpected differential diagnoses in individuals with the tentative diagnosis of Coffin-Siris and Nicolaides-Baraitser syndromes by Nuria C Bramswig( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Diagnosis and management of Silver-Russell syndrome: first international consensus statement by Emma L Wakeling( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

The germline variants in DNA repair genes in pediatric medulloblastoma: a challenge for current therapeutic strategies by Joanna Trubicka( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Immortalization of T-Cells Is Accompanied by Gradual Changes in CpG Methylation Resulting in a Profile Resembling a Subset of T-Cell Leukemias by Sofie Degerman( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

We have previously described gene expression changes during spontaneous immortalization of T-cells, thereby identifying cellular processes important for cell growth crisis escape and unlimited proliferation. Here, we analyze the same model to investigate the role of genome-wide methylation in the immortalization process at different time points pre-crisis and post-crisis using high-resolution arrays. We show that over time in culture there is an overall accumulation of methylation alterations, with preferential increased methylation close to transcription start sites (TSSs), islands, and shore regions. Methylation and gene expression alterations did not correlate for the majority of genes, but for the fraction that correlated, gain of methylation close to TSS was associated with decreased gene expression. Interestingly, the pattern of CpG site methylation observed in immortal T-cell cultures was similar to clinical T-cell acute lymphoblastic leukemia (T-ALL) samples classified as CpG island methylator phenotype positive. These sites were highly overrepresented by polycomb target genes and involved in developmental, cell adhesion, and cell signaling processes. The presence of non-random methylation events in in vitro immortalized T-cell cultures and diagnostic T-ALL samples indicates altered methylation of CpG sites with a possible role in malignant hematopoiesis
 
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Audience Level
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Alternative Names
Chrzanowska, Krystyna.

Chrzanowska, Krystyna H.

Krystyna Chrzanowska investigadora polaca

Krystyna Chrzanowska investigadora polonesa

Krystyna Chrzanowska polska lekarka, pediatra, zajmująca się genetyką kliniczną

Krystyna Chrzanowska Pools onderzoekster

Krystyna Chrzanowska researcher, ORCID id # 0000-0003-3888-0624

Krystyna Chrzanowska ricercatrice polacca

Languages
English (14)