WorldCat Identities

Betoulle, Stéphane

Overview
Works: 21 works in 22 publications in 2 languages and 31 library holdings
Roles: Contributor, Other, Opponent, Thesis advisor, Author
Publication Timeline
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Most widely held works by Stéphane Betoulle
Etude cellulaire et moléculaire de l'apoptose chez l'huître plate Ostrea edulis en réponse au parasite Bonamia ostreae by Ophélie Gervais( )

1 edition published in 2016 in French and held by 2 WorldCat member libraries worldwide

The flat oyster, Ostrea edulis, is the European endemic oyster species. Its production has been reduced because of overfishing and diseases including bonamiosis. Massive mortalities observed on the Pacific cupped oyster these last years explained the wish of shellfish farmers to diversify their production and their revival of interest for this patrimonial oyster species. However, bonamiosis due to the protozoan, Bonamia ostreae, is still a major problem for the production of this species. Measures to control the disease are limited and require a better knowledge of the interactions between the flat oyster and the parasite. Previous studies have suggested the involvement of apoptosis in flat oyster defense mechanisms against B. ostreae. This mechanism is involved in various biological mechanisms including defense against pathogens. In this context, the main objective of this PhD work was to better characterize the involvement of the apoptosis during interactions between the flat oyster and the parasite B. ostreae. In a first step, some tools were developed in order to study the apoptotic process at the cellular level using flow cytometry and microscopy as well as at the molecular level by measuring apoptotic gene expression. In a second step, these tools were used to study O. edulis-B. ostreae interactions in vitro and in vivo. Obtained results confirm the involvement of apoptosis in the response of the flat oyster to B. ostreae and demonstrate the ability of the parasite to inhibit the apoptosis pathway in order to survive and multiply within the hemocytes. Finally, the apoptotic response has been investigated in the flat and Pacific oysters after exposure to diverse micro-organism: OsHV-1, Vibrio aestuarianus and micro-algae
Former uranium mine-induced effects in caged roach: a multiparametric approach for the evaluation of in situ metal toxicity by Béatrice Gagnaire( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

A potential biomarker of androgen exposure in European bullhead (Cottus sp.) kidney by Mélanie Villeret( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Acclimation capacity of the three-spined stickleback (Gasterosteus aculeatus, L.) to a sudden biological stress following a polymetallic exposure by Antoine Le Guernic( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

In situ experiments to assess effects of constraints linked to caging on ecotoxicity biomarkers of the three-spined stickleback (Gasterosteus aculeatus L.) by Antoine Le Guernic( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Liquid biopsies for omics-based analysis in sentinel mussels( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Juvenile roach (Rutilus rutilus) increase their anaerobic metabolism in response to copper exposure in laboratory conditions by Virginie Maes( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Action du lindane sur l'activité sécrétrice (radicaux libres oxygénés et cytokines à activité "MAF" des cellules phagocytaires de truite arc-en-ciel (Oncorhynchus mykiss) : implication du calcium intracellulaire by Stéphane Betoulle( Book )

2 editions published in 1998 in French and held by 2 WorldCat member libraries worldwide

LES EFFETS DU LINDANE (INSECTICIDE ORGANOCHLORE) (2,5 A 200 M) ONT ETE EXAMINES IN VITRO SUR LES PRODUCTIONS DE RADICAUX LIBRES OXYGENES (RLO) ET DE CYTOKINES A ACTIVITE MACROPHAGE-ACTIVATING-FACTOR (MAF) PAR DES CELLULES PHAGOCYTAIRES ISOLEES A PARTIR DU REIN ANTERIEUR DE TRUITE ARC-EN-CIEL. LE LINDANE AUGMENTE DE FACON DOSE-DEPENDANTE, LA PRODUCTION DE RADICAUX LIBRES OXYGENES PAR LES PHAGOCYTES EN ACTIVANT LA PROTEINE KINASE C. LE MECANISME EST INDEPENDANT DU CALCIUM INTRACELLULAIRE POUR LES CONCENTRATIONS LES PLUS BASSES OU LE LINDANE CONDUIT EGALEMENT A UNE PRODUCTION PAR LES PHAGOCYTES DE CYTOKINES PRESENTANT UNE ACTIVITE MAF ; CETTE PRODUCTION EST INDEPENDANTE DES LYMPHOCYTES T. LE TRAITEMENT DES CELLULES AVEC DU LINDANE S'ACCOMPAGNE D'UNE AUGMENTATION DOSE-DEPENDANTE DE LA CA#2#+#I, PLUS IMPORTANTE POUR LES PHAGOCYTES DU REIN ANTERIEUR QUE POUR LES LEUCOCYTES DU SANG PERIPHERIQUE. LE LINDANE CONDUIT A UNE AUGMENTATION DE LA CA#2#+#I PAR ENTREE DE CALCIUM DANS LA CELLULE ET PAR MOBILISATION DE LA RESERVE CALCIQUE DU RETICULUM ENDOPLASMIQUE, A PARTIR DE 50 M. APRES 5 MINUTES D'EXPOSITION AU LINDANE, UNE MORTALITE DES CELLULES INTERVIENT, SIGNIFICATIVE A PARTIR DE LA DOSE DE 100 M. UNE PREINCUBATION DE 5 MINUTES DE LYMPHOCYTES T ET B AVEC DU LINDANE ABOUTIT A UNE INHIBITION IMPORTANTE ET DOSE-DEPENDANTE, DE LEUR PROLIFERATION MITOGENQUE. UNE CONTAMINATION AIGUE DE TRUITES PAR DU LINDANE POURRAIT DONC CONDUIRE A UNE IMMUNODEPRESSION ASSOCIEE A UN STRESS OXYDATIF AU NIVEAU DES ORGANES LYMPHOIDES (REIN ANTERIEUR EN PARTICULIER) PAR DECLENCHEMENT D'UNE IMPORTANTE PRODUCTION D'ESPECES REACTIVES DE L'OXYGENE ET DE CYTOKINES MAF, INITIANT UNE REACTION INFLAMMATOIRE ET ABOUTISSANT A UNE CYTOTOXICITE LIEE A L'EXCES DE RLO ET DE CALCIUM DANS LES CELLULES ; CETTE CYTOTOXICITE SE FAISANT RESSENTIR AU NIVEAU DES CELLULES LYMPHOCYTAIRES. AINSI, NOS RESULTATS OBTENUS IN VITRO NOUS PERMETTENT D'EMETTRE DES HYPOTHESES ET DE MIEUX COMPRENDRE LES MECANISMES IMMUNOTOXICOLOGIQUES DU LINDANE MIS EN JEU IN VIVO CHEZ LE POISSON
In situ effects of metal contamination from former uranium mining sites on the health of the three-spined stickleback (Gasterosteus aculeatus, L.) by Antoine Le Guernic( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Host-parasites transfer of micropollutants and eco-physiological consequences on a freshwater fish : case study of chub-acanthocephalan model by Noëlie Molbert( )

1 edition published in 2020 in English and held by 1 WorldCat member library worldwide

Exposure to complex mixtures of environmental contaminants may have severe consequences in free-living. Under natural conditions, organisms are also exposed to other stressors, including parasites. Both chemical exposure and parasite infection have been well studied and documented, but have in many cases been investigated independently from one another. However, it is crucial to simultaneously assess their combined effect on wild organisms given that parasites may interfere with the fate of environmental contaminants within their host through their bioaccumulation capacity. Based on a field study, completed by an experimental approach, I investigated the fate and consequences of six families of organic contaminants, and some of their metabolites, in a host-parasite system composed of a freshwater fish, the European chub, Squalius cephalus, and its intestinal parasite, Pomphorhynchus sp. from the Marne River, France. Specifically, I investigated whether intestinal parasites were able to accumulate toxicants and how their presence affected the stress response of their definitive host exposed to environmental contaminants, at different biological levels with the use of general biomarkers (telomere, lysozyme, peroxidase, antioxidants, oxidative damage, gut microbiota, Fulton's index and hepatosomatic index). Importantly, we demonstrated that intestinal worms were able to accumulate organic contaminants, detoxify their hosts and that their effects on the host shifted from negative to positive as chemical exposure increased
DROPPE - la DReissène comme Outil éPurateur des Protozoaires dans les Effluents de STEP by Elodie Geba( )

1 edition published in 2019 in French and held by 1 WorldCat member library worldwide

Wastewater treatment plant (WWTP) effluents are the source of many chemical and biological contaminations, and the treatments used are inefficient for some of them. Among biological contaminants, some are the focus for new research, such as three human pathogenic protozoan parasites: Toxoplasma gondii, Cryptosporidium parvum and Giardia duodenalis. Indeed, these protozoa are clearly identified as public health priorities since they correspond to the three main parasites responsible for waterborne outbreaks. The aim of this doctoral work is to investigate the use of Dreissena polymorpha, a freshwater bivalve mollusc (zebra mussel), as a tool for bioremediation of protozoa in WWTP effluent. For this, the kinetics of protozoa accumulation and depuration by zebra mussel were characterized over 21 days, in order to evaluate the bioextraction capacity of this bivalve. The survival and health status of zebra mussels in WWTP effluent were also assessed in situ. These experiments showed that mussels survived in WWTP effluent and were also capable of extracting and integrating the protozoa present in the environment. Additional experiments were carried out to better understand the fate of parasites bioaccumulated by D. polymorpha as regards viability and infectivity. This work highlights the interest of Dreissena polymorpha as a tool for bioremediation of protozoa, particularly in wastewater treatment plant effluent
Effets sublétaux d'une contamination métallique liée à des rejets miniers uranifères sur l'épinoche à trois épines (Gasterosteus aculeatus L.). Implication dans la susceptibilité envers un stress biologique. by Antoine Le guernic( )

1 edition published in 2015 in French and held by 1 WorldCat member library worldwide

Uranium extraction has resulted in a remobilisation of this actinide into mine surrounding ecosystems. Uses of metal salts during mining site rehabilitation, and the natural presence of metals have increased the metal contamination in hydrosystems submitted to mine tailings.In situ experiments were conducted in two former French uranium mining sites. Three-spined stickleback caging was used to determine the sublethal effects of this metal mixture on this freshwater fish, as well as its effects on fish susceptibility to a sudden biological stress.This pollution, characterised by higher metal concentrations (especially for uranium), has led to an oxidative stress in sticklebacks visible through several biomarkers, and other effects dependent on the study site. The polymetallic contamination has modified the stickleback responses to the biological stress, by preventing their phagocytic and antioxidant responses. This work has reinforced the interest of the caging technique during environmental studies and that of immunomarkers in a multi-biomarker approach
Le chabot comme espèce modèle pour évaluer les effets des perturbateurs endocriniens by Mélanie Villeret( )

1 edition published in 2012 in French and held by 1 WorldCat member library worldwide

The aim of this study was to assess the potential of the European bullhead (Cottus sp.) as a model species for studying the in situ effects of endocrine disruptors compounds (EDCs). To achieve this goal, this work began by studying the reproduction of wild populations of bullheads. In fact, bullheads present a complex mode of reproduction and this step seemed to be an essential prerequisite before considering the use of this species as an indicator of the contamination by endocrine disruptors. This first step confirmed the existence of two reproductive strategies in bullhead (annual or seasonal) in our study area inherent in the program INTERREG and highlighted the environmental factors that are responsible for this phenomenon. Furthermore, this study allows to confirm the hypertrophy in the kidney of male bullhead during the breeding period and to develop a histological method to quantify it : the measurement of the kidney epithelium height (KEH). This work then consisted in characterizing the response levels measured in bullhead in controlled conditions and in the field. Laboratory studies, using androgenic or no androgenic reference substances, have allowed to determine the inducibility, the sensitivity and the specificity of the renal hypertrophy. In situ investigations were used to assess the discriminating power of this indicator but also to decide on the potential of bullhead as a model species to evaluate the effects of EDCs with other markers reflecting endocrine disruption.The results showed that using the KEH method in bullheads as an indicator of exposure to androgens was not relevant for both laboratory and field studies. Indeed, it appeared to be weakly inducible and less sensitive than those already available in other species. Moreover, response profiles observed in the field did not allow to discriminate references and contaminated sites as the responses of others biomarkers used. In summary, this work shows the weak potential of bullhead to provide information on endocrine disruption. Nevertheless, efforts need to continue in order to identify and caracterize the molecular signals responsible for histological changes in order to develop and validate a specific and sensitive quantitative assay which could be used as a biomarker of androgenicity. In this way, bullhead could be considering as a sentinel species for monitoring aquatic
Le métabolisme énergétique chez un cyprinidé d'eau douce, le gardon Rutilus rutilus : vers le développement de nouveaux biomarqueurs en lien avec la contamination par des produits phytosanitaires. by Virginie Maes( )

1 edition published in 2014 in French and held by 1 WorldCat member library worldwide

The energy metabolism constitutes an appropriate approach for the development of biomarkers allowing to estimate the health status of animals and to predict the effects of contaminants on higher levels of biological organization. Indeed, it participates in the establishment of key functions such as reproduction or growth. Alterations of energy allocation process by the contamination can affect the fate of individuals and populations. The aim of this study was to determine in laboratory the potentials effects of chemicals (copper and ethofumaste) on energy metabolism of a cyprinid species, the roach Rutilus rutilus, through the study of processes involved in the synthesis of cellular energy (ATP). The effect of chemicals was first performed on general health status of juvenile roach, and few impacts were found on general indexes measured. Secondly, the study of aerobic and anaerobic energy production (glycolysis, substrates and products) was performed. Significant differences were observed at the molecular regulation level, depending on chemicals. However, at the biochemical level, an increase in anaerobic metabolism was observed with both contaminants. Finally, the effects of contaminants on mitochondrial functions were assessed. Mitochondrial alterations were observed either in the respiratory chain and in the ultra-structure of mitochondria;these results involved an effect on the availability of cellular energy. This work constitutes the basis for the development of new early markers of physiological disorders in organisms used in biomonitoring studies
Evaluation de la contamination des éléments traces dans les eaux et sédiments de la lagune de Lomé et bioaccumulation chez deux espèces de poisson by Tchaa Badassan( )

1 edition published in 2021 in French and held by 1 WorldCat member library worldwide

The Lomé lagoon system is located in the extreme southwest of Togo, bordering the Gulf of Guinea. From East to West, it consists of Lake Bè (29ha), Lake East (31 ha) and Lake West (20 ha). It represents the final receptacle for runoff and untreated wastewater in the city of Lomé. These inputs, sources of various pollutants, contribute to the pollution of the lagoon. However, in this ecosystem, there are certain aquatic species that are the subject of fishing. The objective of this study is to contribute to a better knowledge of the chemical quality of the lagoon ecosystem by paying particular attention to the contamination of fish by trace elements (TE). 24 water samples and 18 sediment samples were taken in the dry and rainy seasons. The water analyzes focused on basic physicochemical parameters (pH, EC, T, dissolved DOC, major anions and cations) and inorganic TEs. The results showed a weak seasonal influence on the composition of the physicochemical parameters of the water. The ionic composition of this brackish water is predominantly dominated by chlorides and sodium, the average contents of which in the rainy season and in the dry season represent 66% and 69% of the total dissolved salts respectively. TEs such as Sr, B, Mn, Ba and Fe have the highest concentrations of an order of magnitude between 102 to 103. On the fine fraction of sediments, the concentrations of major elements, TE, of rare earths and their seasonal and spatial distribution were studied. The distribution profiles of rare earths show in all seasons, enrichments in light rare earths greater than those of heavy rare earths. Cerium (Ce) anomalies are less visible and less variable between seasons than Europium (Eu) anomalies. The La/Yb ratios are positively correlated with the percentage of Al and Fe oxides and with the percentage of the fine fraction. TE concentrations vary little with the season, but show strong variations from one TE to another. The degrees of enrichment obtained are moderate for Bi, Cr, Ga, Mo, Pb, Sn, Zn (1.5 <FE <5) to significant for As, Cd and Sb (5 <FE <20) for all the sites of the East Lake. For the West Lake sites, the degrees of enrichment obtained are moderate for As, Cd, Cu, Mo and Pb (1.5 <FE <5) to significant for As, Bi, Cd, Pb, Sb, Sn and Zn (5 <FE <20). TEs such as As, Cd, Cu and Ni have total concentrations that are within the range of variation of guideline values for sediment quality. On the other hand, the concentrations of TEs such as Cr, Pb and Zn are higher than the guide values. The determined PEL and ERM quotients rank the majority of sites as low to moderately low priorities for As, Cd and Cu. The high priorities concern mainly the sites of the East Lake (in particular S7 for Zn, S8 and S9 for the Pb and Zn) and the sites of the West Lake (in particular Zn for all the sites). As for the non-residual fraction (%) of TE, As, Bi, Ni, V, Mo and Sc present the lowest fractions (5% to 15%) and Cd the highest fraction (47% to 55%). In this lagoon system, individuals of C. Anguillaris and S. melanotheron were chosen to assess the bioconcentration of TE as well as the health risks associated with their consumption. As, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb and Zn were assayed in 60 individuals of each species. The concentrations of TE As, Cr, Cu, Fe, Mn, Zn obtained in both species and of Pb in S. melanotheron are above the quality standards for human consumption. The health risk assessment showed that only As (QD>1) would constitute a risk element when individuals consume S. Melanotheron. Thus, all the matrices which were the subject of this study are moderately contaminated. However, this ecosystem deserves continuous monitoring over time and space
Caractérisations structurale et fonctionnelle des populations hémocytaires de la moule zébrée (Dreissena sp.) en vue de leur utilisation en évaluation du risque écotoxicologique. by Lauris Evariste( )

1 edition published in 2016 in French and held by 1 WorldCat member library worldwide

Extension of human activities is responsible of molecule releases and climate changes that may affect physiology of aquatic organisms. The zebra mussel has biological traits making it an interesting species for environmental monitoring. In this organism, hemocyte cells constitute an interesting target to develop a multi-biomarker approach. These cells possess multiple functionalities and are involved in all major physiological functions of the species and in homeostasis regulation. The objective of this work was to develop analytical tools to study hemocyte responses of zebra mussels. Experiments allowed characterizing structure of hemocyte populations and their functionalities linked with phagocytosis process. Use of these biomarkers in various contexts indicated an important adaptation capacity of the species to environmental conditions. Results highlighted interest to analyze hemocyte activities at sub-population scale comparatively to global approach that does not consider hemocyte diversity. It was demonstrated that factor such as reproductive status or sampled species (D. polymorpha vs D. bugensis) constitute important confounding factors. Studies also demonstrated a strong positioning of phagocytosis assay as a sensitive marker to contaminants. This work constitutes a data set destined to be used in multiple contexts such as ecotoxicology or ecophysiology
Motilité cellulaire et immunocompétente des hémocytes de mollusques marins : applications aux diagnostics environnementaux by Damien Rioult( )

1 edition published in 2013 in French and held by 1 WorldCat member library worldwide

La moule bleue Mytilus edulis est un mollusque bivalve filtreur et sessile. Cet organisme présente un intérêt majeur d'une part en conchyliculture et d'autre part dans de nombreux programmes de surveillance environnementale comme espèce indicatrice du niveau de contamination par les xénobiotiques. Ce manuscrit propose une revue de la compréhension actuelle des mécanismes de l'immunité exclusivement innée des invertébrés, en s'attachant plus particulièrement au rôle prévalent des cellules immunocompétentes chez Mytilus : les hémocytes. Nos résultats permettent de proposer une classification des sous-populations hémocytaires de Mytilus edulis. A partir de colorations cytologiques classiques combinées à la cytométrie en flux et au volume Coulter ainsi que d'une caractérisation originale des motilités cellulaires par videomicroscopie d'intervalle (time-lapse), nos résultats proposent une description des activités et des interactions d'au moins trois sous-populations hémocytaires : les basophiles, les hyalinocytes et les granulocytes éosinophiles. La vitesse de migration des hémocytes a été mesurée in vitro par une nouvelle méthode, le tracking des noyaux. Cette approche permet de quantifier les activités migratoires de ces cellules ainsi que leurs perturbations, notamment par les stress environnementaux. Le second axe développé consiste en une analyse du phénotype de Multi Xenobiotic Resistance (MXR) au sein des sous-populations hémocytaires. Ce travail indique également que les transporteurs ABCC/MR Prégulent la motilité des cellules, ce qui ouvre des perspectives importantes
Outils alternatifs à l'expérimentation animale pour l'évaluation de la toxicité des contaminants de l'environnement : lignées cellulaires et tests embryo-larvaires chez un poisson modèle le Médaka japonais, Oryzias latipes by Pauline Pannetier( )

1 edition published in 2018 in French and held by 1 WorldCat member library worldwide

Les poissons sont parmi les modèles aquatiques les plus utilisés pour l'évaluationdes dangers des substances chimiques avant leur mise sur le marché européen(REACh (Registration, Evaluation, Autorisation and Restriction of CHemicals)).Actuellement, cette réglementation ainsi que la directive européenne sur la protectiondes animaux utilisés à des fins scientifiques (2010/63/UE) promeuvent la mise enplace de méthodes alternatives en expérimentation animale. Ces méthodes ont pourbut de remplacer les modèles animaux chaque fois que cela est possible, de réduirele nombre d'animaux utilisés en expérimentation et d'optimiser la méthodologieappliquée aux animaux. Cette thèse vise à comparer la sensibilité de deux de cesoutils alternatifs, les lignées cellulaires et les tests embryo-larvaires poissons, enutilisant des toxiques modèles puis mettre en oeuvre ces outils pour évaluer la toxicitéde mélanges environnementaux de polluants : microplastiques et hydrocarbures(pétrole Arabian Light). Les composés modèles (B(a)P, Cd, MMS, PCB126) ont permisde valider trois biomarqueurs : la production d'espèces réactives de l'oxygène surlignées cellulaires de poissons, le test micronoyaux par cytométrie en flux et lechallenge infectieux sur larves de Médaka. Ces biomarqueurs associés à des analyseschimiques, biochimiques et physiologiques ont permis d'évaluer la toxicité demélanges environnementaux d'hydrocarbures (extrait aqueux de pétrole Arabian =WAF) et de microplastiques. Les WAF présentent une toxicité sur les lignéescellulaires de poissons (induction de l'activité EROD, génotoxicité) ainsi que surembryons et larves de Médaka (comportement, biométrie, EROD, génotoxicité). Lespoissons comme les cellules sont particulièrement sensibles au WAF de l'ArabianLight. La contamination aux microplastiques (MP) environnementaux a révélé unetoxicité des contaminants associés au MP sur les lignées cellulaires et les larves depoisson. L'ingestion de particules de plastiques par les larves a induit des effets létauxet sublétaux (biométrie, comportement et EROD). L'ingestion des particules plastiquespar les larves a été confirmée par microscopie biphotonique. Cette étude a permisd'évaluer la sensibilité et la complémentarité de ces outils in vitro pour l'évaluation desdangers et des risques associés aux substances chimiques
Field biomonitoring using the zebra mussel Dreissena polymorpha and the quagga mussel Dreissena bugensis following immunotoxic reponses. Is there a need to separate the two species?( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Abstract: The zebra mussel, Dreissena polymorpha constitutes an extensively used sentinel species for biomonitoring in European and North American freshwater systems. However, this invasive species is gradually replaced in freshwater ecosystem by Dreissena bugensis, a closely related dreissenid species that shares common morphological characteristics but possess some physiological differences. However, few are known about differences on more integrated physiological processes that are generally used as biomarkers in biological monitoring studies. Declining of zebra mussel populations raises the question of the sustainability of using one or both species indifferently to maintain the quality of environmental pollution monitoring data. In our study, we performed a field comparative study measuring immune-related markers and bioaccumulation of PCBs, PAHs and PBDEs in sympatrically occurring mussel populations from three sites of the St. Lawrence River. For tested organisms, species were identified using RFLP analysis. Measurement of bioaccumulated organic compounds indicated a higher accumulation of PCBs and PBDEs in D. bugensis soft tissues compared to D. polymorpha while no differences were noticed for PAHs. Results of hemocytic parameters highlighted that differences of hemocyte distributions were associated to modulations of phagocytic activities. Moreover, marked differences occurred in measurement of hemocytic oxidative activity, indicating divergences between the two species for ROS regulation strategies. This physiological characteristic may deeply influence species responses facing environmental or pollution related stress and induce bias if the two species are not differentiated in further biomarker or bioaccumulation measurement-based studies. Graphical abstract: Highlights: Dreissena polymorph a and Dreissena bugensi s were used for field biomonitoring study. Organic compound bioaccumulation and immune-related markers were measured. Organic compound bioaccumulation was higher in D. bugensis compared to D. polymorpha . Hemocytic responses highlighted different ROS regulation strategies between species
 
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